Q2G0J1 · CHDC_STAA8

Function

function

Involved in coproporphyrin-dependent heme b biosynthesis (PubMed:25908396).
Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway (By similarity).
The reaction occurs in a stepwise manner with a three-propionate harderoheme intermediate (By similarity).
Can stimulate the generation of protoporphyrin IX, but not coproporphyrin III, by HemY (PubMed:27597779).

Catalytic activity

Cofactor

Fe-coproporphyrin III (UniProtKB | Rhea| CHEBI:68438 )

Note: Fe-coproporphyrin III acts both as a substrate and a redox cofactor (By similarity).
Was originally thought to use heme as a cofactor (PubMed:25908396).

Pathway

Porphyrin-containing compound metabolism; protoheme biosynthesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site131Fe-coproporphyrin III (UniProtKB | ChEBI)
Active site145
Binding site145-149Fe-coproporphyrin III (UniProtKB | ChEBI)
Binding site172Fe (UniProtKB | ChEBI) of Fe-coproporphyrin III (UniProtKB | ChEBI); axial binding residue
Binding site185Fe-coproporphyrin III (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionheme binding
Molecular Functionmetal ion binding
Molecular Functionperoxidase activity
Biological Processheme biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Coproheme decarboxylase
  • EC number
  • Alternative names
    • Coproheme III oxidative decarboxylase
    • Fe-coproporphyrin III oxidase/dehydrogenase
    • Hydrogen peroxide-dependent heme synthase

Gene names

    • Name
      chdC
    • Synonyms
      hemQ
    • Ordered locus names
      SAOUHSC_00573

Organism names

Accessions

  • Primary accession
    Q2G0J1

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002940461-250Coproheme decarboxylase

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the ChdC family. Type 1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    250
  • Mass (Da)
    29,390
  • Last updated
    2006-03-21 v1
  • Checksum
    B991C3DB917160E0
MSQAAETLDGWYSLHLFYAVDWASLRIVPKDERDALVTEFQSFLENTATVRSSKSGDQAIYNITGQKADLLLWFLRPEMKSLNHIENEFNKLRIADFLIPTYSYVSVIELSNYLAGKSDEDPYENPHIKARLYPELPHSDYICFYPMNKRRNETYNWYMLTMEERQKLMYDHGMIGRKYAGKIKQFITGSVGFDDFEWGVTLFSDDVLQFKKIVYEMRFDETTARYGEFGSFFVGHIINTNEFDQFFAIS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000253
EMBL· GenBank· DDBJ
ABD29716.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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