Q2FXA5 · CGOX_STAA8

Function

function

Involved in coproporphyrin-dependent heme b biosynthesis (PubMed:25908396).
Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III (PubMed:25908396, PubMed:27597779).
Can also oxidize protoporphyrinogen IX (PubMed:27597779).

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per subunit.

Activity regulation

The generation of protoporphyrin IX, but not coproporphyrin III, is stimulated by heme-bound HemQ. This stimulatory effect is mediated by superoxide (PubMed:27597779).
Inhibited by acifluorfen analogs (PubMed:25908396).

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
0.31 μMcoproporphyrinogen III
6.7 μMcoproporphyrinogen III
kcat is 1.33 min-1 with coproporphyrinogen III as substrate (PubMed:25908396).
kcat is 0.46 min-1 with coproporphyrinogen III as substrate (PubMed:27597779).
kcat is 0.44 min-1 with protoporphyrinogen IX as substrate (PubMed:27597779).

Pathway

Porphyrin-containing compound metabolism; protoheme biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site9-14FAD (UniProtKB | ChEBI)
Binding site34-35FAD (UniProtKB | ChEBI)
Binding site42FAD (UniProtKB | ChEBI)
Binding site56-59FAD (UniProtKB | ChEBI)
Binding site254FAD (UniProtKB | ChEBI)
Binding site446-448FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionoxidoreductase activity
Molecular Functionoxygen-dependent protoporphyrinogen oxidase activity
Biological Processheme biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Coproporphyrinogen III oxidase
  • EC number
  • Alternative names
    • Coproporphyrin III synthase

Gene names

    • Name
      cgoX
    • Synonyms
      hemY
    • Ordered locus names
      SAOUHSC_01960

Organism names

Accessions

  • Primary accession
    Q2FXA5

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004502811-466Coproporphyrinogen III oxidase

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    466
  • Mass (Da)
    51,983
  • Last updated
    2006-03-21 v1
  • Checksum
    F732B045F34C4B79
MTKSVAIIGAGITGLSSAYFLKQQDPNIDVTIFEASNRPGGKIQSYRKDGYMIELGPESYLGRKTIMTELAKDIGLEQDIVTNTTGQSYIFAKNKLYPIPGGSIMGIPTDIKPFVTTKLISPLGKLRAGFDLLKKPTQMQDGDISVGAFFRARLGNEVLENLIEPLMGGIYGTDIDKLSLMSTFPNFKEKEEAFGSLIKGMKDEKNKRLKQRQLYPGAPKGQFKQFKHGLSSFIEALEQDVKNKGVTIRYNTSVDDIITSQKQYKIVYNDQLEEVYDGVLVTTPHQVFLNWFGQDPAFDYFKTMDSTTVATVVLAFDEKDIENTHDGTGFVIARTSDTDITACTWTSKKWPFTTPEGKVLIRAYVGKPGDTVVDDHTDNELVSIVRRDLSQMMTFKGDPEFTIVNRLPKSMPQYHVGHIQQIRQIQAHIKQTYPRLRVTGASFEAVGLPDCITQGKVAAEEVIAEL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000253
EMBL· GenBank· DDBJ
ABD31021.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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