Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

Q2F7M0 · Q2F7M0_LIMRT

Function

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Divalent metal cations. Prefers magnesium or manganese.
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for active site, binding site.

151350100150200250300350400450500
Type
IDPosition(s)Description
Active site92Proton donor
Active site165Proton acceptor
Binding site236a divalent metal cation (UniProtKB | ChEBI)
Binding site237a divalent metal cation (UniProtKB | ChEBI)
Binding site260a divalent metal cation (UniProtKB | ChEBI)
Binding site405substrate
Binding site449substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmalic enzyme activity
Molecular Functionmalolactic enzyme activity
Molecular Functionmetal ion binding
Molecular FunctionNAD binding
Molecular Functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Processmalate metabolic process
Biological Processmalolactic fermentation
Biological Processpyruvate metabolic process

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Malic enzyme

Gene names

    • ORF names
      lr1476

Organism names

Accessions

  • Primary accession
    Q2F7M0

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain69-251Malic enzyme N-terminal
Domain261-513Malic enzyme NAD-binding

Sequence similarities

Belongs to the malic enzymes family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    513
  • Mass (Da)
    56,478
  • Last updated
    2006-03-21 v1
  • MD5 Checksum
    57958DD31EADD5D1333251414EA7FC27
MLRKGMQILNDPFKNKGTAFTIEERKKYGLLGLLPSCVRTIEEQADEIYRLYQSKNSRIEQRHLLMEVFNTNRTLFFYLMEKHIAEFMPVVYDPVIAEAIEQYNERYIKPQDAAYLSIEHPDLIKEELADAADGRDIRLIVVTDAEGILGIGDWGVNGVDISVGKLMVYTAAAGIDPSQVLPVSIDAGTNNEKLLKDPHYLGNRMKRVEGQPYFDFIDKFVDAVEGLFPKSLLHFEDFGRGTAARILDKYQDKILTFNDDIQGTGIIALAGVLGAMNISKEKLTDQTFLTFGAGTAGMGIAKMLYDELIRQGLTPEEAKKHFYLVDRQGLLFDDTPGLTPKQKPFTRQRSEFANADELTNLLAVVKAVHPTVMIGTSTQPGSFDEAVVKEMAAHTLRPVIFPLSNPTKLAEAKAADLLKWTDGKALIATGIPVKDIEYNGTVYQIGQANNALIYPGVGFGALAAEAKVLNDNMLAAAAHALSGLVDPEKPGAAVLPPVSKLTEFSKRVAERVA

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue513

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ233703
EMBL· GenBank· DDBJ
ABD13935.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help