Q29RY4 · RNZ1_BOVIN

  • Protein
    Zinc phosphodiesterase ELAC protein 1
  • Gene
    ELAC1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Specifically involved in tRNA repair: acts downstream of the ribosome-associated quality control (RQC) pathway by removing a 2',3'-cyclic phosphate from tRNAs following cleavage by ANKZF1. tRNAs are then processed by TRNT1.

Catalytic activity

  • Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.
    EC:3.1.26.11 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions.

Features

Showing features for binding site, active site.

136350100150200250300350
TypeIDPosition(s)Description
Binding site62Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site64Zn2+ 1 (UniProtKB | ChEBI); catalytic
Active site66Proton acceptor
Binding site66Zn2+ 2 (UniProtKB | ChEBI); catalytic
Binding site67Zn2+ 2 (UniProtKB | ChEBI); catalytic
Binding site182Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site253Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site253Zn2+ 2 (UniProtKB | ChEBI); catalytic
Binding site313Zn2+ 2 (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular Function3'-tRNA processing endoribonuclease activity
Molecular Functionmetal ion binding
Molecular FunctiontRNA-specific ribonuclease activity
Biological Processrescue of stalled ribosome
Biological ProcesstRNA 3'-end processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Zinc phosphodiesterase ELAC protein 1
  • EC number
  • Alternative names
    • ElaC homolog protein 1
    • Ribonuclease Z 1 (RNase Z 1)
    • tRNA 3 endonuclease 1
    • tRNase Z 1

Gene names

    • Name
      ELAC1

Organism names

  • Taxonomic identifier
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    Q29RY4

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm, cytosol
Nucleus
Note: Mainly cytosolic.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002406011-363Zinc phosphodiesterase ELAC protein 1

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the RNase Z family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    363
  • Mass (Da)
    39,979
  • Last updated
    2006-04-04 v1
  • Checksum
    2A6886919D497471
MSMDVTFLGTGAAYPSPTRGASALVLRCEGECWLFDCGEGTQTQLMKSQLKAGRITKIFITHLHGDHFFGLPGLLCTISLQSGSMVTKQPIEIYGPVGLRDFIWRTMELSHTELVFPYVVHELVPTADQCPTEELQESVQVDKTDNPPKEGEGRTILLDSEENSYLLVDDEQFVVKAFRLFHRIPSFGFSVVEKKRPGKLNAQKLKDLGVPPGPAYGKLKNGISVVLENGVTISPQDVLKKPIVGRKICILGDCSGVVDDAGVKLCFEADLLIHEATLDDTQMDKAKEHGHSTPQMAATFAKLCQAKRLVLTHFSQRYKPVALAREGEADGIVELKKQAESVLDLQEVTLAEDFMVISIPIKK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC113356
EMBL· GenBank· DDBJ
AAI13357.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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