Q29KG4 · AFFL_DROPS

Function

function

Has a role in transcriptional regulation. Acts in parallel with the Ras/MAPK and the PI3K/PKB pathways in the control of cell identity and cellular growth. Essential for regulation of the cytoskeleton and cell growth but not for cell proliferation or growth rate. Required specifically for the microtubule-based basal transport of lipid droplets. Plays a partially redundant function downstream of Raf in cell fate specification in the developing eye. Pair-rule protein that regulates embryonic cellularization, gastrulation and segmentation (By similarity).

Features

Showing features for dna binding.

117702004006008001,0001,2001,4001,600
TypeIDPosition(s)Description
DNA binding900-912A.T hook

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular Functiontranscription coregulator activity
Biological Processperiodic partitioning by pair rule gene
Biological Processregulation of cytoskeleton organization
Biological Processregulation of DNA-templated transcription
Biological Processregulation of lipid transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    AF4/FMR2 family member lilli
  • Alternative names
    • Protein lilliputian

Gene names

    • Name
      lilli
    • ORF names
      GA21343

Organism names

  • Taxonomic identifier
  • Strain
    • MV2-25 / Tucson 14011-0121.94
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q29KG4

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00003946771-1770AF4/FMR2 family member lilli
Modified residue470Phosphoserine
Modified residue472Phosphoserine
Modified residue863Phosphoserine
Modified residue864Phosphoserine
Modified residue920Phosphoserine
Modified residue922Phosphoserine
Modified residue1442Phosphoserine

Keywords

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-28Disordered
Region134-327Disordered
Compositional bias156-201Polar residues
Compositional bias241-282Polar residues
Region402-660Disordered
Compositional bias450-482Basic and acidic residues
Compositional bias483-505Polar residues
Compositional bias521-560Polar residues
Compositional bias567-659Polar residues
Region761-805Disordered
Compositional bias766-789Polar residues
Region822-1173Disordered
Compositional bias908-934Polar residues
Compositional bias951-974Polar residues
Compositional bias997-1042Polar residues
Compositional bias1068-1098Polar residues
Compositional bias1105-1131Polar residues
Compositional bias1132-1154Basic and acidic residues
Compositional bias1291-1308Basic and acidic residues
Region1291-1390Disordered
Compositional bias1320-1361Basic and acidic residues
Compositional bias1368-1388Basic and acidic residues
Compositional bias1483-1501Polar residues
Region1483-1502Disordered
Region1656-1683Disordered

Sequence similarities

Belongs to the AF4 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,770
  • Mass (Da)
    188,886
  • Last updated
    2008-10-14 v2
  • Checksum
    59A03A81699B7F68
MAQQQQQQQQQQHLQHPHQNTNSNNQLQQQQQQLQLQLQLQLQEQQEQQQQQLQLQQYNNNFYSQNYNMEEYERRKRREREKIERQQGIQIDDRETALFSEPRRLTEGDAEITAALGEFGDARVYINQSTVGISRHAPGAGNPRLQAPPPPKTLGHSHSPSSSSAAGSGSGSALPGQSQSQQQQQKQHYQQQQQQQRPPGYLKQADNKPPYNGRGGYPGQPMKNDIPSSSGMAPPRGPPRSGSGSISNSNSNSSSATNNATGGAAGTTPLGPPLSTQMPNGREKSFLGPPAPALHNGAGLFVPPAASKRPGGGSGAGLQPPPPEKDITKMISEMTNSFRVTAPLTSIAATPHAPTRENYNLNGPNTNKYAFGPIGSPPIGSQPSSLMAPLFAPIAPIASPITSLLTTPPHASQGSLGGASPVAPLQQLPPTPPKAAAALSPTAAAKPLKTEKNHTLEKQDSCLENDLELSESEDEQRKKESRSAGNSSNSSESDSSESGSESSSKGDHQQQHHHHNHHHQQQQQQLQQQQQQQLLQQKQQHQQILQQQQRQLTANGSKKKYSHSIIAGGGSTISGLLTSSGFGSGGAGNGGCSTASSGGGGGGSGSGGGSGSSSGIGTMSSGSSSNKTPSPTESNKWTLSRFFPKPANQTSSESVSPGNVSMKVPGILPGGAQIIPESIEVTTAIVKNEKIHDDHMDMDEVEEEDEDEEQLQQQQQLRYGAGLSVTPVAVAVKKEALDGVGEMGGLPAIPKNQIKREAEALHSAARLSDSGTSGSGSTSSSSSSSDSAPGEVVPMPGPGETLQLPGVPAAITTVMRVHPTLMQKAPPNSVTLTPILPLPASPKQRQKKPRKKKPATSAPILDSSDDDDPPAAKHALELSAAAAAAAQAQATATVPPLAVKKGRGRPRKQQQSGGSGNLSSASAGSSSQTKGPTLTAAKKPLVKGPAMANSRKRDHSSQSSSNGNTPTKKLAMGTGTGTGTAMAVPMTVIPSGPANASAVAAASSSSDEDSSSSTGSTGSKSSSSSSSSDDTETTQNTKCRIVKLNKTGAVPPLARLGAVASAGAGAGAGASGSSSPSSSSSEPEDHLAMSTVSALPMAQQLMQPYKPRAVSQHSQQLSSSECSSSSGSSTSGDEDEAKREKERERKRKSDKNKISTLTRIFNPKEGGAKKQGQVVIMDQSEEQQQVKVGDSSSQPVPVQNAAIAKLRMTPTQQQQQLGAGLASPARTTTPHLTSLICKIDLSKLSRERIMRLKKLTPSQQNGHLTPKDLVTIQTQGPSQPVQGHLLPAKVKHEHPHPVKPEPELDAGYESKFKPGNVKQEFQLKQERDRERERERDRDRERERERERDREREREQPTGGRRRKRSSSSSSSPYKEKKRKKEKSDHLQISKDQLLPVPVLLPSNNHERISCHERLSFDKLQLLHEDAAAVAAAAAAVSAPNGSPSKKLLVMSPLPPPPTAVVVPPAVVAPSTCSEAVQTTPPSAAATATAATSTTGTSTAPPAPVTRLIYRSYFDREEEPHSDDHRKNNQFLVEAVNRKHAADSERDSFNQVTLYLEAVVYFLLTADSMERSSSEQATWTIYKDTLSLIKFISSKFRPYQQSTNGQHETHNKVAILSLRCQSLISLKLYKLRRTNCRTVINSLTEFFRTGRGDIVNGNTPSSISPSNSVGSQGSGSNTPPGKIVPQEIHTQLSKQNEYLTYVNSAHELWDQADRLVRTGNHIDFFRELDHENGPLTLHSTMPEVFRYVQAGLKTLRDAVSHPTQQTLHQSH

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias156-201Polar residues
Compositional bias241-282Polar residues
Compositional bias450-482Basic and acidic residues
Compositional bias483-505Polar residues
Compositional bias521-560Polar residues
Compositional bias567-659Polar residues
Compositional bias766-789Polar residues
Compositional bias908-934Polar residues
Compositional bias951-974Polar residues
Compositional bias997-1042Polar residues
Compositional bias1068-1098Polar residues
Compositional bias1105-1131Polar residues
Compositional bias1132-1154Basic and acidic residues
Compositional bias1291-1308Basic and acidic residues
Compositional bias1320-1361Basic and acidic residues
Compositional bias1368-1388Basic and acidic residues
Compositional bias1483-1501Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH379061
EMBL· GenBank· DDBJ
EAL33211.2
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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