Q29HB2 · MMSA_DROPS
- ProteinProbable methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids520 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Probable malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine.
Catalytic activity
- 2-methyl-3-oxopropanoate + NAD+ + CoA + H2O = propanoyl-CoA + hydrogencarbonate + NADH + H+This reaction proceeds in the forward direction.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 169 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 171 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 195 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 198 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 199 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 248 | NAD+ (UniProtKB | ChEBI) | |||
Active site | 303 | Nucleophile | |||
Binding site | 403 | NAD+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | malonate-semialdehyde dehydrogenase (acetylating) activity | |
Molecular Function | methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity | |
Biological Process | thymine catabolic process | |
Biological Process | thymine metabolic process | |
Biological Process | valine catabolic process | |
Biological Process | valine metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
- EC number
- Short namesMMSDH
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ29HB2
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain, transit peptide.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000312824 | ?-520 | Probable methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial | ||
Transit peptide | 1-? | Mitochondrion | |||
Expression
Gene expression databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length520
- Mass (Da)56,064
- Last updated2006-04-04 v1
- ChecksumE8336961D816B35D
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CH379064 EMBL· GenBank· DDBJ | EAL31846.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. |