Q29HB2 · MMSA_DROPS

Function

function

Probable malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine.

Catalytic activity

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site169NAD+ (UniProtKB | ChEBI)
Binding site171NAD+ (UniProtKB | ChEBI)
Binding site195NAD+ (UniProtKB | ChEBI)
Binding site198NAD+ (UniProtKB | ChEBI)
Binding site199NAD+ (UniProtKB | ChEBI)
Binding site248NAD+ (UniProtKB | ChEBI)
Active site303Nucleophile
Binding site403NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrion
Molecular Functionmalonate-semialdehyde dehydrogenase (acetylating) activity
Molecular Functionmethylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
Biological Processthymine catabolic process
Biological Processthymine metabolic process
Biological Processvaline catabolic process
Biological Processvaline metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
  • EC number
  • Short names
    MMSDH
  • Alternative names
    • Malonate-semialdehyde dehydrogenase [acylating]

Gene names

    • ORF names
      GA14712

Organism names

  • Taxonomic identifier
  • Strain
    • MV2-25 / Tucson 14011-0121.94
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q29HB2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, transit peptide.

Type
IDPosition(s)Description
ChainPRO_0000312824?-520Probable methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial
Transit peptide1-?Mitochondrion

Expression

Gene expression databases

    • FBgn0074739Expressed in female reproductive system and 3 other cell types or tissues

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    520
  • Mass (Da)
    56,064
  • Last updated
    2006-04-04 v1
  • Checksum
    E8336961D816B35D
MAFLRAIGAEARYLTQRAYSSAAPTTKLFIDGKFVESKTKEWIDVHDPATNKVVTRVPKATQDEMQTALESNKKAFRSWSNQSILTRQAVMFKLQALIKENMGELAKNITKEQGKTLADAEGDVLRGLQVVEHCCSIPSLQMGETVANVARDMDTYSLVMPLGVTAGIAPFNFPAMIPLWMFPVAITTGNTMLLKPSERVPGATMLLMELLNEAGCPPGVVNVIHGQHDAVNFICDAPAIKAVSFVGSDQAGKYIYERAGKNGKRVQSNMGAKNHGVILSDANKENTLNQLAGAAFGAAGQRCMALSTAVFVGDAQGWIPDLVERAQKLKVNAGHVPGTDVGPVISAASRQRINDLIESGVKEGAKLILDGRKISVPGFEDGYFVGPTILSDVTPSMKCYTEEIFGPVLVILKADNLDDAIDIVNANPYGNGTAVFTTNGAAARKFVNEIDAGQVGVNVPIPVPLPMFSFTGTRGSFRGDHHFYGKQGIKFYTQTKTVTQLWRETDVNHTQAAVAMPTMK

Sequence caution

The sequence EAL31846.1 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CH379064
EMBL· GenBank· DDBJ
EAL31846.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp