Q29558 · MAOX_PIG

  • Protein
    NADP-dependent malic enzyme
  • Gene
    ME1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Catalyzes the oxidative decarboxylation of (S)-malate in the presence of NADP+ and divalent metal ions, and decarboxylation of oxaloacetate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Divalent metal cations. Prefers magnesium or manganese.

Features

Showing features for active site, binding site, site.

TypeIDPosition(s)Description
Active site88Proton donor
Binding site141NADP+ (UniProtKB | ChEBI)
Active site159Proton acceptor
Binding site231a divalent metal cation (UniProtKB | ChEBI)
Binding site232a divalent metal cation (UniProtKB | ChEBI)
Binding site255a divalent metal cation (UniProtKB | ChEBI)
Binding site255NADP+ (UniProtKB | ChEBI)
Site255Important for activity
Binding site394NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrion
Molecular Functionmagnesium ion binding
Molecular Functionmalate dehydrogenase (decarboxylating) (NADP+) activity
Molecular Functionmalic enzyme activity
Molecular Functionmanganese ion binding
Molecular FunctionNAD binding
Molecular Functionoxaloacetate decarboxylase activity
Biological Processmalate metabolic process
Biological Processprotein homotetramerization
Biological Processpyruvate metabolic process
Biological Processresponse to hormone

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADP-dependent malic enzyme
  • EC number
  • Short names
    NADP-ME
  • Alternative names
    • Malic enzyme 1

Gene names

    • Name
      ME1

Organism names

  • Taxonomic identifier
  • Strain
    • Large white
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus

Accessions

  • Primary accession
    Q29558

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001601941-557NADP-dependent malic enzyme
Modified residue322Phosphoserine

Keywords

Proteomic databases

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the malic enzymes family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    557
  • Mass (Da)
    62,006
  • Last updated
    1996-11-01 v1
  • Checksum
    40692545F044BA99
GYGLTRIPHLNKDLAFTLEERQQLNIHGLLPPCFISQDIQVLRVIKNFERLNSDFDRYLLLMDLQDRNEKLFYKVLMSDIEKFMPIVYTPTVGLACQQYSLAFRKPRGLFISIHDRGHVASVLNAWPEDVIKAVVVTDGERILGLGDLGCNGMGIPVGKLALYTACGGVNPQECLPVILDVGTENEELLKDPLYIGLRQRRVRGPEYDDFLDEFMEAVSSKYGMNCLIQFEDFANINAFRLLKKYQNQYCTFNDDIQGTASVAVAGILAALRITKNKLSDQTILFQGAGEAALGIAHLIVMAMEKEGVPKEKAIKKIWLVDSKGLIVKGRAALTNEKEEFAHEHEEMKNLEAIVQDIKPTALIGVAAIGGAFSEQILKDMAAFNERPIIFALSNPTSKAECTAERGYTLTQGRAIFASGSPFDPVTLPSGQTLYPGQGNNSYVFPGVALAVVACGLRHITDKIFLTTAEVIAQQVSDKHLEEGRLYPPLNTIRDVSLKIAEKIVRDAYQEKTATIYPEPSNKEAFVRSQMYSTDYDQILPDGYSWPEEAQKIQTKLD

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X93016
EMBL· GenBank· DDBJ
CAA63599.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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