Q29041 · FCN2_PIG
- ProteinFicolin-2
- GeneFCN2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids323 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin (By similarity).
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | collagen trimer | |
Cellular Component | collagen-containing extracellular matrix | |
Cellular Component | extracellular space | |
Molecular Function | antigen binding | |
Molecular Function | carbohydrate binding | |
Molecular Function | carbohydrate derivative binding | |
Molecular Function | metal ion binding | |
Molecular Function | signaling receptor binding | |
Biological Process | complement activation, lectin pathway |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameFicolin-2
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus
Accessions
- Primary accessionQ29041
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-26 | |||||
Sequence: MDTRGVAAAMRPLVLLVAFLCTAAPA | ||||||
Chain | PRO_0000269571 | 27-323 | Ficolin-2 | |||
Sequence: LDTCPEVKVVGLEGSDKLSILRGCPGLPGAAGPKGEAGASGPKGGQGPPGAPGEPGPPGPKGDRGEKGEPGPKGESWETEQCLTGPRTCKELLTRGHILSGWHTIYLPDCQPLTVLCDMDTDGGGWTVFQRRSDGSVDFYRDWAAYKRGFGSQLGEFWLGNDHIHALTAQGTNELRVDLVDFEGNHQFAKYRSFQVADEAEKYMLVLGAFVEGNAGDSLTSHNNSLFTTKDQDNDQYASNCAVLYQGAWWYNSCHVSNLNGRYLGGSHGSFANGVNWSSGKGYNYSYKVSEMKFRAT | ||||||
Disulfide bond | 108↔136 | |||||
Sequence: CLTGPRTCKELLTRGHILSGWHTIYLPDC | ||||||
Disulfide bond | 115↔143 | |||||
Sequence: CKELLTRGHILSGWHTIYLPDCQPLTVLC | ||||||
Glycosylation | 249 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 267↔280 | |||||
Sequence: CAVLYQGAWWYNSC | ||||||
Glycosylation | 302 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 310 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Mainly expressed in skeletal muscle.
Interaction
Subunit
Homotrimer. Interacts with elastin. Interacts with MASP1 and MASP2.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 52-102 | Collagen-like | ||||
Sequence: GLPGAAGPKGEAGASGPKGGQGPPGAPGEPGPPGPKGDRGEKGEPGPKGES | ||||||
Region | 55-107 | Disordered | ||||
Sequence: GAAGPKGEAGASGPKGGQGPPGAPGEPGPPGPKGDRGEKGEPGPKGESWETEQ | ||||||
Compositional bias | 86-100 | Basic and acidic residues | ||||
Sequence: PKGDRGEKGEPGPKG | ||||||
Domain | 106-323 | Fibrinogen C-terminal | ||||
Sequence: EQCLTGPRTCKELLTRGHILSGWHTIYLPDCQPLTVLCDMDTDGGGWTVFQRRSDGSVDFYRDWAAYKRGFGSQLGEFWLGNDHIHALTAQGTNELRVDLVDFEGNHQFAKYRSFQVADEAEKYMLVLGAFVEGNAGDSLTSHNNSLFTTKDQDNDQYASNCAVLYQGAWWYNSCHVSNLNGRYLGGSHGSFANGVNWSSGKGYNYSYKVSEMKFRAT |
Domain
The fibrinogen-like domain (FBG) contains calcium-binding sites that may be involved in carbohydrate binding.
Sequence similarities
Belongs to the ficolin lectin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length323
- Mass (Da)34,682
- Last updated1996-11-01 v1
- Checksum849BF031D77E16B7
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 86-100 | Basic and acidic residues | ||||
Sequence: PKGDRGEKGEPGPKG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L12344 EMBL· GenBank· DDBJ | AAA92455.1 EMBL· GenBank· DDBJ | mRNA |