Q28942 · FCG3A_PIG

  • Protein
    Low affinity immunoglobulin gamma Fc region receptor III-A
  • Gene
    FCGR3A
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG) (PubMed:31323052).
Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger (By similarity).
Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation (By similarity).
Fc-binding subunit that associates with FCER1G adapter to form functional signaling complexes. Following the engagement of antigen-IgG complexes, triggers phosphorylation of immunoreceptor tyrosine-based activation motif (ITAM)-containing adapter with subsequent activation of phosphatidylinositol 3-kinase signaling and sustained elevation of intracellular calcium that ultimately drive NK cell activation (By similarity).
Mediates enhanced ADCC in response to afucosylated IgGs (PubMed:34485821).

Features

Showing features for site.

125720406080100120140160180200220240
TypeIDPosition(s)Description
Site223Important for receptor turnover

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentexternal side of plasma membrane
Molecular FunctionIgG binding
Molecular FunctionIgG receptor activity
Biological Processantibody-dependent cellular cytotoxicity
Biological Processcell surface receptor signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Low affinity immunoglobulin gamma Fc region receptor III-A
  • Short names
    IgG Fc receptor III-A
  • Alternative names
    • Cytolytic trigger molecule G7
    • Fc-gamma RIII (FcRIII)
    • Fc-gamma RIII-alpha (FcgammaRIIIA
      )
  • CD Antigen Name
    • CD16a

Gene names

    • Name
      FCGR3A
    • Synonyms
      FCGR3

Organism names

  • Taxonomic identifier
  • Strain
    • Minnesota miniature
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Suina > Suidae > Sus

Accessions

  • Primary accession
    Q28942
  • Secondary accessions
    • Q28940
    • Q28941

Proteomes

Subcellular Location

Cell membrane
; Single-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain20-209Extracellular
Transmembrane210-230Helical
Topological domain231-257Cytoplasmic

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant55in clone 284.4
Natural variant149in clone 334.8
Natural variant181in clone 334.8
Natural variant186in clone 334.8

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 4 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-19
ChainPRO_000001515520-257Low affinity immunoglobulin gamma Fc region receptor III-A
Disulfide bond48↔90
Glycosylation64N-linked (GlcNAc...) asparagine
Disulfide bond129↔173
Glycosylation134N-linked (GlcNAc...) asparagine
Glycosylation162N-linked (GlcNAc...) asparagine
Glycosylation181N-linked (GlcNAc...) asparagine; in variant N-181

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in polymorphonuclear leukocytes, pulmonary alveolar macrophages and peripheral blood mononuclear cells (at protein level) (PubMed:8077673).
Found in spleen, and at very low levels in lymph nodes but not in thymus or liver (PubMed:8077673).

Interaction

Subunit

Forms a heterooligomeric complex with ITAM-containing signaling subunits FCER1G. Interacts (via transmembrane domain) with signaling subunits; this interaction is a prerequisite for receptor complex expression on the cell surface and intracellular signal transduction. Binds the Fc region of antigen-complexed IgG.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain25-104Ig-like C2-type 1
Domain108-190Ig-like C2-type 2

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    257
  • Mass (Da)
    29,062
  • Last updated
    1997-11-01 v1
  • Checksum
    1D038CC1552B97CB
MWQLLSPTALLLLVSVPGTHAEDPPKSVVILDPPWDRLLEKDSVTLKCQGAYPPRDDSTEWRWNGTLISNKASSYSITDATVGNSGEYTCKTGLSAQSDPLRLEVYKGWLLLQAPRWVVQEGESIRLRCHTWKNITIQKVQYFQNGMGKKFSHQNFEYHIPNATLKDGGSYFCRGIIKNYDLSSEPVKVTVQGSKSPSPILSFFLPWHQIIFCLVMGFLFAVDTGLYFSVRKVLRSSKEDWRNGKVTWSRDPADKGG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U08993
EMBL· GenBank· DDBJ
AAA57190.1
EMBL· GenBank· DDBJ
mRNA
U08991
EMBL· GenBank· DDBJ
AAA57188.1
EMBL· GenBank· DDBJ
mRNA
U08992
EMBL· GenBank· DDBJ
AAA57189.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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