Q28905 · PF2R_SHEEP

  • Protein
    Prostaglandin F2-alpha receptor
  • Gene
    PTGFR
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentextracellular region
Cellular Componentplasma membrane
Molecular Functionprostaglandin F receptor activity
Biological Processadenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Processcellular response to prostaglandin D stimulus
Biological Processinflammatory response
Biological Processnegative regulation of apoptotic process
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of cytosolic calcium ion concentration
Biological Processpositive regulation of gene expression
Biological Processresponse to estradiol
Biological Processresponse to lipopolysaccharide

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Prostaglandin F2-alpha receptor
  • Short names
    PGF receptor; PGF2-alpha receptor
  • Alternative names
    • Prostanoid FP receptor

Gene names

    • Name
      PTGFR

Organism names

  • Taxonomic identifier
  • Strain
    • Western range
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Caprinae > Ovis

Accessions

  • Primary accession
    Q28905

Proteomes

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-31Extracellular
Transmembrane32-54Helical; Name=1
Topological domain55-69Cytoplasmic
Transmembrane70-90Helical; Name=2
Topological domain91-109Extracellular
Transmembrane110-131Helical; Name=3
Topological domain132-152Cytoplasmic
Transmembrane153-175Helical; Name=4
Topological domain176-198Extracellular
Transmembrane199-224Helical; Name=5
Topological domain225-250Cytoplasmic
Transmembrane251-267Helical; Name=6
Topological domain268-285Extracellular
Transmembrane286-307Helical; Name=7
Topological domain308-362Cytoplasmic

Keywords

Phenotypes & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 6 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00000700731-362Prostaglandin F2-alpha receptor
Glycosylation4N-linked (GlcNAc...) asparagine
Glycosylation19N-linked (GlcNAc...) asparagine
Disulfide bond108↔186

Keywords

Proteomic databases

PTM databases

Expression

Developmental stage

Expression is high in the midluteal phase corpus luteum and decreases during luteolysis.

Gene expression databases

Interaction

Protein-protein interaction databases

Chemistry

Structure

Family & Domains

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing. Isoform FP-A and isoform FP-B have identical ligand binding properties but different G protein coupling properties.

Q28905-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    FP-A
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    362
  • Mass (Da)
    40,985
  • Last updated
    1996-11-01 v1
  • Checksum
    83604FC18EADF583
MSTNNSVQPVSPASELLSNTTCQLEEDLSISFSIIFMTVGILSNSLAIAILMKAYQRFRQKYKSSFLLLASALVITDFFGHLINGTIAVFVYASDKDWIYFDKSNILCSIFGICMVFSGLCPLFLGSLMAIERCIGVTKPIFHSTKITTKHVKMMLSGVCFFAVFVALLPILGHRDYKIQASRTWCFYKTDQIKDWEDRFYLLLFAFLGLLALGISFVCNAITGISLLKVKFRSQQHRQGRSHHFEMVIQLLGIMCVSCICWSPFLVTMASIGMNIQDFKDSCERTLFTLRMATWNQILDPWVYILLRKAVLRNLYVCTRRCCGVHVISLHVWELSSIKNSLKVAAISDLPVTEKVTQQTST

Q28905-2

  • Name
    FP-B
  • Note
    Shows agonist-independent constitutive activity, but is still responsive to agonist.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 317-362: VCTRRCCGVHVISLHVWELSSIKNSLKVAAISDLPVTEKVTQQTST → I

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict6in Ref. 2; AAB51070
Alternative sequenceVSP_001951317-362in isoform FP-B

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U73798
EMBL· GenBank· DDBJ
AAB51070.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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