Q28905 · PF2R_SHEEP
- ProteinProstaglandin F2-alpha receptor
- GenePTGFR
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids362 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | extracellular region | |
Cellular Component | plasma membrane | |
Molecular Function | prostaglandin F receptor activity | |
Biological Process | adenylate cyclase-activating G protein-coupled receptor signaling pathway | |
Biological Process | cellular response to prostaglandin D stimulus | |
Biological Process | inflammatory response | |
Biological Process | negative regulation of apoptotic process | |
Biological Process | positive regulation of cell population proliferation | |
Biological Process | positive regulation of cytosolic calcium ion concentration | |
Biological Process | positive regulation of gene expression | |
Biological Process | response to estradiol | |
Biological Process | response to lipopolysaccharide |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameProstaglandin F2-alpha receptor
- Short namesPGF receptor; PGF2-alpha receptor
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Caprinae > Ovis
Accessions
- Primary accessionQ28905
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-31 | Extracellular | ||||
Sequence: MSTNNSVQPVSPASELLSNTTCQLEEDLSIS | ||||||
Transmembrane | 32-54 | Helical; Name=1 | ||||
Sequence: FSIIFMTVGILSNSLAIAILMKA | ||||||
Topological domain | 55-69 | Cytoplasmic | ||||
Sequence: YQRFRQKYKSSFLLL | ||||||
Transmembrane | 70-90 | Helical; Name=2 | ||||
Sequence: ASALVITDFFGHLINGTIAVF | ||||||
Topological domain | 91-109 | Extracellular | ||||
Sequence: VYASDKDWIYFDKSNILCS | ||||||
Transmembrane | 110-131 | Helical; Name=3 | ||||
Sequence: IFGICMVFSGLCPLFLGSLMAI | ||||||
Topological domain | 132-152 | Cytoplasmic | ||||
Sequence: ERCIGVTKPIFHSTKITTKHV | ||||||
Transmembrane | 153-175 | Helical; Name=4 | ||||
Sequence: KMMLSGVCFFAVFVALLPILGHR | ||||||
Topological domain | 176-198 | Extracellular | ||||
Sequence: DYKIQASRTWCFYKTDQIKDWED | ||||||
Transmembrane | 199-224 | Helical; Name=5 | ||||
Sequence: RFYLLLFAFLGLLALGISFVCNAITG | ||||||
Topological domain | 225-250 | Cytoplasmic | ||||
Sequence: ISLLKVKFRSQQHRQGRSHHFEMVIQ | ||||||
Transmembrane | 251-267 | Helical; Name=6 | ||||
Sequence: LLGIMCVSCICWSPFLV | ||||||
Topological domain | 268-285 | Extracellular | ||||
Sequence: TMASIGMNIQDFKDSCER | ||||||
Transmembrane | 286-307 | Helical; Name=7 | ||||
Sequence: TLFTLRMATWNQILDPWVYILL | ||||||
Topological domain | 308-362 | Cytoplasmic | ||||
Sequence: RKAVLRNLYVCTRRCCGVHVISLHVWELSSIKNSLKVAAISDLPVTEKVTQQTST |
Keywords
- Cellular component
Phenotypes & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 6 variants from UniProt as well as other sources including ClinVar and dbSNP.
Chemistry
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000070073 | 1-362 | Prostaglandin F2-alpha receptor | |||
Sequence: MSTNNSVQPVSPASELLSNTTCQLEEDLSISFSIIFMTVGILSNSLAIAILMKAYQRFRQKYKSSFLLLASALVITDFFGHLINGTIAVFVYASDKDWIYFDKSNILCSIFGICMVFSGLCPLFLGSLMAIERCIGVTKPIFHSTKITTKHVKMMLSGVCFFAVFVALLPILGHRDYKIQASRTWCFYKTDQIKDWEDRFYLLLFAFLGLLALGISFVCNAITGISLLKVKFRSQQHRQGRSHHFEMVIQLLGIMCVSCICWSPFLVTMASIGMNIQDFKDSCERTLFTLRMATWNQILDPWVYILLRKAVLRNLYVCTRRCCGVHVISLHVWELSSIKNSLKVAAISDLPVTEKVTQQTST | ||||||
Glycosylation | 4 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 19 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 108↔186 | |||||
Sequence: CSIFGICMVFSGLCPLFLGSLMAIERCIGVTKPIFHSTKITTKHVKMMLSGVCFFAVFVALLPILGHRDYKIQASRTWC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Developmental stage
Expression is high in the midluteal phase corpus luteum and decreases during luteolysis.
Gene expression databases
Structure
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing. Isoform FP-A and isoform FP-B have identical ligand binding properties but different G protein coupling properties.
Q28905-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameFP-A
- Length362
- Mass (Da)40,985
- Last updated1996-11-01 v1
- Checksum83604FC18EADF583
Q28905-2
- NameFP-B
- NoteShows agonist-independent constitutive activity, but is still responsive to agonist.
- Differences from canonical
- 317-362: VCTRRCCGVHVISLHVWELSSIKNSLKVAAISDLPVTEKVTQQTST → I
Features
Showing features for sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 6 | in Ref. 2; AAB51070 | ||||
Sequence: S → C | ||||||
Alternative sequence | VSP_001951 | 317-362 | in isoform FP-B | |||
Sequence: VCTRRCCGVHVISLHVWELSSIKNSLKVAAISDLPVTEKVTQQTST → I |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U73798 EMBL· GenBank· DDBJ | AAB51070.1 EMBL· GenBank· DDBJ | mRNA |