Q28755 · PAG1_SHEEP

  • Protein
    Pregnancy-associated glycoprotein 1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Has no proteolytic activity.

Caution

Lacks the conserved Asp active site at position 272.

Features

Showing features for site.

138250100150200250300350
TypeIDPosition(s)Description
Site272Ancestral active site

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functionaspartic-type endopeptidase activity
Biological Processproteolysis

Names & Taxonomy

Protein names

  • Recommended name
    Pregnancy-associated glycoprotein 1
  • Short names
    PAG 1
  • Alternative names
    • Inactive aspartic protease PAG-1
    • Pregnancy-associated glycoprotein 66d (ovPAG 66d)

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Caprinae > Ovis

Accessions

  • Primary accession
    Q28755
  • Secondary accessions
    • P83496

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, propeptide, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-15
PropeptidePRO_000002610916-53Activation peptide
ChainPRO_000002611054-382Pregnancy-associated glycoprotein 1
Glycosylation57N-linked (GlcNAc...) asparagine
Glycosylation74N-linked (GlcNAc...) asparagine
Disulfide bond102↔110
Glycosylation128N-linked (GlcNAc...) asparagine
Disulfide bond263↔267
Disulfide bond305↔339

Keywords

Proteomic databases

Expression

Tissue specificity

Trophoblast and placental tissue. Produced specifically in the invasive binucleate cells of the placenta.

Developmental stage

Detected in maternal serum soon after implantation and throughout the gestation period.

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain71-379Peptidase A1

Sequence similarities

Belongs to the peptidase A1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    382
  • Mass (Da)
    42,980
  • Last updated
    1997-11-01 v1
  • Checksum
    D28E4D78BB5BFE8C
MKWLVLLGLVAFSECIVKIPLRRVKTMRNTLSGKKMLNSFLKEHAYRLSQISFRASNLTIHPLRNIMDMLYVGNITIGTPPQEFQVVFDTGSSDLLVPSINCLSPTKRPCSKQDKFKHHQSSTFRFTNDTFRIYFGSGTMRGFVAHDTVRIGDLVSTDQPFGLIFLESWLDIPFDGILGLNYPKISFSGAIPIFDKLKNEGAFSEPVFAFYLNKDKQEGSVVMFGGVDHRYYKGELNWVPLIHPGEWSIPLDRISMRRKVIACSGGCEALVGTGTSLILGPRTVVENIQKHIGATQQCFEYFVSCSAVYALPSIVFTINGINYPVPPQAYLVKDSRGQCYSPFQVNRANPSAENWILGDVFLRRYFSVFDRGNDRIGLARAV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M73961
EMBL· GenBank· DDBJ
AAB53144.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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