Q28620 · NPT2A_RABIT

  • Protein
    Sodium-dependent phosphate transport protein 2A
  • Gene
    SLC34A1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Involved in actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane (PubMed:7733319).
The cotransport has a Na+:Pi stoichiometry of 3:1 and is electrogenic (By similarity).

Catalytic activity

Activity regulation

Transport activity is significantly increased in response to dietary phosphate deprivation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical plasma membrane
Cellular Componentbrush border
Cellular Componentplasma membrane
Cellular Componentvesicle
Molecular Functionsodium:phosphate symporter activity
Biological Processcellular response to phosphate starvation
Biological Processintracellular phosphate ion homeostasis
Biological Processphosphate ion homeostasis
Biological Processphosphate ion transport
Biological Processsodium-dependent phosphate transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Sodium-dependent phosphate transport protein 2A
  • Short names
    Sodium-phosphate transport protein 2A
  • Alternative names
    • Na(+)-dependent phosphate cotransporter 2A
    • NaPi-6
    • Sodium/phosphate cotransporter 2A (Na(+)/Pi cotransporter 2A; NaPi-2a)
    • Solute carrier family 34 member 1

Gene names

    • Name
      SLC34A1
    • Synonyms
      SLC17A2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus

Accessions

  • Primary accession
    Q28620

Proteomes

Subcellular Location

Apical cell membrane
; Multi-pass membrane protein
Cell membrane
; Multi-pass membrane protein
Note: Localized at the brush border membranes of the proximal tubules. Internalized from the cell surface upon PTH stimulation.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-106Cytoplasmic
Transmembrane107-128Helical; Name=M1
Topological domain129-148Extracellular
Transmembrane149-166Helical; Name=M2
Topological domain167-168Cytoplasmic
Transmembrane169-188Helical; Name=M3
Topological domain189-350Extracellular
Transmembrane351-373Helical; Name=M4
Topological domain374-415Cytoplasmic
Transmembrane416-439Helical; Name=M5
Topological domain440-469Extracellular
Transmembrane470-490Helical; Name=M6
Topological domain491-516Cytoplasmic
Transmembrane517-537Helical; Name=M7
Topological domain538-542Extracellular
Transmembrane543-564Helical; Name=M8
Topological domain565-642Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, modified residue, disulfide bond, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00000686091-642Sodium-dependent phosphate transport protein 2A
Modified residue14Phosphoserine
Modified residue37Phosphoserine
Disulfide bond228↔525
Glycosylation301N-linked (GlcNAc...) asparagine
Disulfide bond309↔339
Glycosylation326N-linked (GlcNAc...) asparagine
Glycosylation333N-linked (GlcNAc...) asparagine
Modified residue511Phosphothreonine; by PKC
Modified residue610Phosphoserine
Modified residue626Phosphothreonine
Modified residue628Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the kidney cortex.

Induction

Up-regulated by a low-phosphate diet.

Gene expression databases

Interaction

Subunit

Interacts via its C-terminal region with NHERF4. Interacts with NHERF1. Interacts with TMEM174; regulates SLC34A1 internalization by PTH and FGF23 (By similarity).

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the SLC34A transporter family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    642
  • Mass (Da)
    69,432
  • Last updated
    1997-11-01 v1
  • Checksum
    A48B85C001642A8B
MISYGEQLSSPAVSPPLVRAGLRGPMMHGATFAYVPSPQALHRIPGTSAYAFPSLSPVALTEHGCPYGEARERHEPLPAKLALEEEQKPESGWAQELRRTAMTLLKLPLMVTFLYLFVCSLDVLSSAFQLAGGKVAGDIFKDNAILANPVAGLVVGILVTVLVQSSSTATSIIVSMVSSGLLEVSSAIPIIMGSNIGTSVTNTIVALMQAGDRTDFRRAFAGATVHDCFNWLSVLVLLPLEAATGYLHHVTGLVVASFNIRGGRDAPDLLKTITEPFTKLIIQLDRSVITSIATGDESLRNHSLIRIWCHRDPVEASTSMARAETNISRTHGNATMEKCNHIFVDTQLPDLAVGLILLAGSLVLLCTCLILLVKMLNSLLKGQVAKVIQKVINTDLPAPFTWVTGYFAMVVGAAMTFIVQSSSVFTSAITPLVGLGVISIERAYPLTLGSNIGTTTTAILAALASPREKLSSSFQIALCHFFFNISGILLWYPLPCTRLPIRMAKALGKRTAKYRWFAVLYLLVCFLLLPSLVFGISMAGWRAMVGVGAPFGALLAFVVLINVLQSRSPGRLPKWLQTWDFLPHWMHSLQPLDHLITHATLCCSRSEPRSPQLPARVFLEELPPATPSPRLALPAHHNATRL

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5F9DM94A0A5F9DM94_RABITSLC34A1635
A0A5F9D7V8A0A5F9D7V8_RABITSLC34A1671
A0A5F9CT06A0A5F9CT06_RABITSLC34A1342

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U20793
EMBL· GenBank· DDBJ
AAA77682.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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