Q28468 · EDNRB_MACFA

Function

function

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionendothelin receptor activity
Biological Processcalcium-mediated signaling
Biological Processdevelopmental pigmentation
Biological Processendothelin receptor signaling pathway
Biological Processenteric nervous system development
Biological Processregulation of blood pressure
Biological Processvasoconstriction

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Endothelin receptor type B
  • Short names
    ET-B; ET-BR
  • Alternative names
    • Endothelin receptor non-selective type

Gene names

    • Name
      EDNRB

Organism names

Accessions

  • Primary accession
    Q28468

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Note: internalized after activation by endothelins.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-8Extracellular
Transmembrane9-30Helical; Name=3
Topological domain31-51Cytoplasmic
Transmembrane52-76Helical; Name=4
Topological domain77-99Extracellular

Keywords

PTM/Processing

Features

Showing features for chain, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00000694401-99Endothelin receptor type B
Disulfide bond7↔88

Keywords

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Keywords

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Fragment
  • Length
    99
  • Mass (Da)
    10,943
  • Last updated
    1996-11-01 v1
  • Checksum
    AA135608FE26BFCA
PFGAEMCKLVPFIQKASVGITVLSLCALSIDRYRAVASWSRIKGIGIPKWTAVEIVLIWVVSVVLAVPEAIGFDMITMDYKGSYLRICLLHPVQKTAFM

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue99

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U20578
EMBL· GenBank· DDBJ
AAA62437.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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