Q28440 · Q28440_GLOME

Function

function

Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing (By similarity).
In male adult brain involved in the maintenance of motor functions of dopaminergic neurons

Features

Showing features for dna binding.

155510152025303540455055
IVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRD
TypeIDPosition(s)Description
DNA binding1-55HMG box

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnuclear speck
Molecular Functioncalmodulin binding
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processanatomical structure morphogenesis
Biological Processcell differentiation
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processsex differentiation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Sex-determining region Y protein
  • Alternative names
    • Testis-determining factor

Gene names

    • Name
      Sry

Organism names

Accessions

  • Primary accession
    Q28440

Subcellular Location

Keywords

Interaction

Subunit

Interacts with CALM, EP300, HDAC3, KPNB1, ZNF208 isoform KRAB-O, PARP1, SLC9A3R2 and WT1. The interaction with EP300 modulates its DNA-binding activity. The interaction with KPNB1 is sensitive to dissociation by Ran in the GTP-bound form. Interaction with PARP1 impaired its DNA-binding activity.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-55HMG box

Sequence similarities

Belongs to the SRY family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    55
  • Mass (Da)
    6,749
  • Last updated
    1996-11-01 v1
  • Checksum
    B0F44122D4091EB8
IVWSRDQRRKVALENPQMQNSEISKRLGYDWKMLTEAEKQPFFEEAQRLRAMHRD

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue55

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Z26910
EMBL· GenBank· DDBJ
CAA81536.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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