Q27675 · CYAA_LEIDO

  • Protein
    Receptor-type adenylate cyclase A
  • Gene
    RAC-A
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Could act as a receptor for an unknown ligand.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site938Mg2+ (UniProtKB | ChEBI)
Binding site981Mg2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Molecular Functionadenylate cyclase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological ProcesscAMP biosynthetic process
Biological Processintracellular signal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Receptor-type adenylate cyclase A
  • EC number
  • Alternative names
    • ATP pyrophosphate-lyase
    • Adenylyl cyclase

Gene names

    • Name
      RAC-A

Organism names

  • Taxonomic identifier
  • Strain
    • MHOM/SD/62/1S
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leishmania

Accessions

  • Primary accession
    Q27675

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-34Cytoplasmic
Transmembrane35-55Helical
Topological domain56-891Extracellular
Transmembrane892-912Helical
Topological domain913-1380Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00001957341-1380Receptor-type adenylate cyclase A
Glycosylation422N-linked (GlcNAc...) asparagine
Glycosylation478N-linked (GlcNAc...) asparagine
Glycosylation497N-linked (GlcNAc...) asparagine
Glycosylation567N-linked (GlcNAc...) asparagine

Keywords

PTM databases

Expression

Developmental stage

Expressed in the insect stage (promastigote) but not in the mammalian host stage of the parasite life cycle.

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain933-1087Guanylate cyclase
Region1270-1298Disordered

Sequence similarities

Belongs to the adenylyl cyclase class-3 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,380
  • Mass (Da)
    151,694
  • Last updated
    1996-11-01 v1
  • Checksum
    6B2D5F7D3C1107A0
MAMQIRPSLGGCLRHGGAGDHAARRLSRLRAAKVFVPTAVVCVLLCCAPWVMAEITNDAEREPVYILNAMYSTEAYTNEDAKALWTGMDMAFYNSHYKAAGGRPIKILHPDPDQDNLYDIAEVILHSLARQEKLLAVLGPYLDGRLTAALSNADVVQSGLMLIAPFTGSSGVRTWSDSVYFTRAEPMVELKVVLMHIVNRLRARRVAFMRLTGMHFGGEELTYVQDTLTSLLRDPAVLYTVPYSESSVEVDEEAFDAMADTNPQVIIVWAAPVQQVIYFLEKVLTDPRTSSAYVISCSMIQRVVFDVYKRLLSAGSIKPQDGRILASATTSPVSGEGLKYMEVLKAQMSNYIENSGSFDYYPDDDSTETLGRKARSEAPLSRKYTVDEFFQAHPSIAKLMALGWLSGTLVQQTLEQTDWIVNRSTYKAGLFNQNRFVIGGDYVLGDYGGPCEPLAQFLGASCYCNQGGHSSILTVLQNASWDIVPDSSFKYPQSECNSSKSQIVKAVSVLALLNQGYPKLIDAGMQLNEVLPHAFDDNLCKGYKVSSIFLRVETAKAQQLFDAEVSNYSVDIIAGPIFQALDVGEIFVLNPLYNHPQLRTEKRNYVYLMPTLEQQIYVMYSKIDALRTRTDVFEDTAVVLRGYSAQEVVEISEILFKTAGTFNLPDPSVATISFTDSLRGLLSPRAINVVIGMKDGDSAHFANFLAKYTDVMVVVCFDELTMYYEELRATFSVQPTSVQARLMSFSSLPLWTDASAEAKARWPILGHFHKIFPDPINHTPSLLRDVIIAGFIQELVSTTTVAETKLLTNAVYINGGVTTYGFTLGNFEWGCTATTSGDSCVYKNYGASNIEILSIQRMLDPTVPQLSSPSTPTMEYRPRQRSHALTPAQRNGLIAGCVVGAVVLIATCTLLLYCCMDNRNNDAAPKDGDEPVTLLFTDIESSTALWAALPQLMSDAIAAHHRVIRQLVKKYGCYEVKTIGDSFMIACRSAHSAVSLACEIQTKLLKHDWGTEALDRAYREFELARVDTLDDYEPPTARLSEEEYAALWCGLRVRVGIHTGLTDIRYDEVTKGYDYYGDTSNMAARTEAVANGGQVVATEAAWWALSNDERAGIAHTAMGPQGLRGVPFAVEMFQLNAVPGRRHAALRTEIEAILPDDTATDTASSAAGALLSSVETMSDPAAGIAFVLASCFAPYPVAQRVRELQPLLSKWGVGAPPRSRLVSEEDYCQGLMNRLAIRIATVSQARLRLTREDAADGKFKLASSEALNPLAREGDSAAGGVRPRLPGSPVTSLPAGGSSSMREWRVFTRLMNDTQHPSVTHLSQQRPSNLTSFTEAQDAAFPLNAHCGPESRVENSGADDEEIVIVRVSRNPHYARHAFE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U17042
EMBL· GenBank· DDBJ
AAA74998.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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