Q27675 · CYAA_LEIDO
- ProteinReceptor-type adenylate cyclase A
- GeneRAC-A
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1380 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Could act as a receptor for an unknown ligand.
Catalytic activity
- ATP = 3',5'-cyclic AMP + diphosphate
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | adenylate cyclase activity | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Biological Process | cAMP biosynthetic process | |
Biological Process | intracellular signal transduction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameReceptor-type adenylate cyclase A
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leishmania
Accessions
- Primary accessionQ27675
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-34 | Cytoplasmic | ||||
Sequence: MAMQIRPSLGGCLRHGGAGDHAARRLSRLRAAKV | ||||||
Transmembrane | 35-55 | Helical | ||||
Sequence: FVPTAVVCVLLCCAPWVMAEI | ||||||
Topological domain | 56-891 | Extracellular | ||||
Sequence: TNDAEREPVYILNAMYSTEAYTNEDAKALWTGMDMAFYNSHYKAAGGRPIKILHPDPDQDNLYDIAEVILHSLARQEKLLAVLGPYLDGRLTAALSNADVVQSGLMLIAPFTGSSGVRTWSDSVYFTRAEPMVELKVVLMHIVNRLRARRVAFMRLTGMHFGGEELTYVQDTLTSLLRDPAVLYTVPYSESSVEVDEEAFDAMADTNPQVIIVWAAPVQQVIYFLEKVLTDPRTSSAYVISCSMIQRVVFDVYKRLLSAGSIKPQDGRILASATTSPVSGEGLKYMEVLKAQMSNYIENSGSFDYYPDDDSTETLGRKARSEAPLSRKYTVDEFFQAHPSIAKLMALGWLSGTLVQQTLEQTDWIVNRSTYKAGLFNQNRFVIGGDYVLGDYGGPCEPLAQFLGASCYCNQGGHSSILTVLQNASWDIVPDSSFKYPQSECNSSKSQIVKAVSVLALLNQGYPKLIDAGMQLNEVLPHAFDDNLCKGYKVSSIFLRVETAKAQQLFDAEVSNYSVDIIAGPIFQALDVGEIFVLNPLYNHPQLRTEKRNYVYLMPTLEQQIYVMYSKIDALRTRTDVFEDTAVVLRGYSAQEVVEISEILFKTAGTFNLPDPSVATISFTDSLRGLLSPRAINVVIGMKDGDSAHFANFLAKYTDVMVVVCFDELTMYYEELRATFSVQPTSVQARLMSFSSLPLWTDASAEAKARWPILGHFHKIFPDPINHTPSLLRDVIIAGFIQELVSTTTVAETKLLTNAVYINGGVTTYGFTLGNFEWGCTATTSGDSCVYKNYGASNIEILSIQRMLDPTVPQLSSPSTPTMEYRPRQRSHALTPAQRN | ||||||
Transmembrane | 892-912 | Helical | ||||
Sequence: GLIAGCVVGAVVLIATCTLLL | ||||||
Topological domain | 913-1380 | Cytoplasmic | ||||
Sequence: YCCMDNRNNDAAPKDGDEPVTLLFTDIESSTALWAALPQLMSDAIAAHHRVIRQLVKKYGCYEVKTIGDSFMIACRSAHSAVSLACEIQTKLLKHDWGTEALDRAYREFELARVDTLDDYEPPTARLSEEEYAALWCGLRVRVGIHTGLTDIRYDEVTKGYDYYGDTSNMAARTEAVANGGQVVATEAAWWALSNDERAGIAHTAMGPQGLRGVPFAVEMFQLNAVPGRRHAALRTEIEAILPDDTATDTASSAAGALLSSVETMSDPAAGIAFVLASCFAPYPVAQRVRELQPLLSKWGVGAPPRSRLVSEEDYCQGLMNRLAIRIATVSQARLRLTREDAADGKFKLASSEALNPLAREGDSAAGGVRPRLPGSPVTSLPAGGSSSMREWRVFTRLMNDTQHPSVTHLSQQRPSNLTSFTEAQDAAFPLNAHCGPESRVENSGADDEEIVIVRVSRNPHYARHAFE |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000195734 | 1-1380 | Receptor-type adenylate cyclase A | |||
Sequence: MAMQIRPSLGGCLRHGGAGDHAARRLSRLRAAKVFVPTAVVCVLLCCAPWVMAEITNDAEREPVYILNAMYSTEAYTNEDAKALWTGMDMAFYNSHYKAAGGRPIKILHPDPDQDNLYDIAEVILHSLARQEKLLAVLGPYLDGRLTAALSNADVVQSGLMLIAPFTGSSGVRTWSDSVYFTRAEPMVELKVVLMHIVNRLRARRVAFMRLTGMHFGGEELTYVQDTLTSLLRDPAVLYTVPYSESSVEVDEEAFDAMADTNPQVIIVWAAPVQQVIYFLEKVLTDPRTSSAYVISCSMIQRVVFDVYKRLLSAGSIKPQDGRILASATTSPVSGEGLKYMEVLKAQMSNYIENSGSFDYYPDDDSTETLGRKARSEAPLSRKYTVDEFFQAHPSIAKLMALGWLSGTLVQQTLEQTDWIVNRSTYKAGLFNQNRFVIGGDYVLGDYGGPCEPLAQFLGASCYCNQGGHSSILTVLQNASWDIVPDSSFKYPQSECNSSKSQIVKAVSVLALLNQGYPKLIDAGMQLNEVLPHAFDDNLCKGYKVSSIFLRVETAKAQQLFDAEVSNYSVDIIAGPIFQALDVGEIFVLNPLYNHPQLRTEKRNYVYLMPTLEQQIYVMYSKIDALRTRTDVFEDTAVVLRGYSAQEVVEISEILFKTAGTFNLPDPSVATISFTDSLRGLLSPRAINVVIGMKDGDSAHFANFLAKYTDVMVVVCFDELTMYYEELRATFSVQPTSVQARLMSFSSLPLWTDASAEAKARWPILGHFHKIFPDPINHTPSLLRDVIIAGFIQELVSTTTVAETKLLTNAVYINGGVTTYGFTLGNFEWGCTATTSGDSCVYKNYGASNIEILSIQRMLDPTVPQLSSPSTPTMEYRPRQRSHALTPAQRNGLIAGCVVGAVVLIATCTLLLYCCMDNRNNDAAPKDGDEPVTLLFTDIESSTALWAALPQLMSDAIAAHHRVIRQLVKKYGCYEVKTIGDSFMIACRSAHSAVSLACEIQTKLLKHDWGTEALDRAYREFELARVDTLDDYEPPTARLSEEEYAALWCGLRVRVGIHTGLTDIRYDEVTKGYDYYGDTSNMAARTEAVANGGQVVATEAAWWALSNDERAGIAHTAMGPQGLRGVPFAVEMFQLNAVPGRRHAALRTEIEAILPDDTATDTASSAAGALLSSVETMSDPAAGIAFVLASCFAPYPVAQRVRELQPLLSKWGVGAPPRSRLVSEEDYCQGLMNRLAIRIATVSQARLRLTREDAADGKFKLASSEALNPLAREGDSAAGGVRPRLPGSPVTSLPAGGSSSMREWRVFTRLMNDTQHPSVTHLSQQRPSNLTSFTEAQDAAFPLNAHCGPESRVENSGADDEEIVIVRVSRNPHYARHAFE | ||||||
Glycosylation | 422 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 478 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 497 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 567 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
PTM databases
Expression
Developmental stage
Expressed in the insect stage (promastigote) but not in the mammalian host stage of the parasite life cycle.
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 933-1087 | Guanylate cyclase | ||||
Sequence: TLLFTDIESSTALWAALPQLMSDAIAAHHRVIRQLVKKYGCYEVKTIGDSFMIACRSAHSAVSLACEIQTKLLKHDWGTEALDRAYREFELARVDTLDDYEPPTARLSEEEYAALWCGLRVRVGIHTGLTDIRYDEVTKGYDYYGDTSNMAARTE | ||||||
Region | 1270-1298 | Disordered | ||||
Sequence: LAREGDSAAGGVRPRLPGSPVTSLPAGGS |
Sequence similarities
Belongs to the adenylyl cyclase class-3 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,380
- Mass (Da)151,694
- Last updated1996-11-01 v1
- Checksum6B2D5F7D3C1107A0