Q27393 · Q27393_DROME
- ProteinAurora kinase
- GeneaurA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids421 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 174 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 193 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 242-244 | ATP (UniProtKB | ChEBI) | ||||
Sequence: EYA | ||||||
Active site | 289 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 293-294 | ATP (UniProtKB | ChEBI) | ||||
Sequence: EN | ||||||
Binding site | 307 | ATP (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromosome passenger complex | |
Cellular Component | cytoplasm | |
Cellular Component | kinetochore | |
Cellular Component | spindle microtubule | |
Cellular Component | spindle midzone | |
Cellular Component | spindle pole centrosome | |
Molecular Function | ATP binding | |
Molecular Function | protein serine/threonine kinase activity | |
Molecular Function | protein serine/threonine/tyrosine kinase activity | |
Biological Process | asymmetric protein localization involved in cell fate determination | |
Biological Process | centrosome cycle | |
Biological Process | centrosome separation | |
Biological Process | mitotic centrosome separation | |
Biological Process | mitotic spindle organization | |
Biological Process | pole cell formation | |
Biological Process | regulation of cytokinesis | |
Biological Process | regulation of protein localization | |
Biological Process | symmetric cell division |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAurora kinase
- EC number
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ27393
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for cross-link.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Cross-link | 291 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K |
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-19 | Basic and acidic residues | ||||
Sequence: MSHPSDHVLRPKENAPHRM | ||||||
Region | 1-93 | Disordered | ||||
Sequence: MSHPSDHVLRPKENAPHRMPEKSAAVLNMQKNLLLGKKPNSENMAPDSKPLPGSSGALIRSAATTVRPATKPGLGGSNSIASSEGNNFQKPMV | ||||||
Compositional bias | 71-93 | Polar residues | ||||
Sequence: KPGLGGSNSIASSEGNNFQKPMV | ||||||
Region | 106-156 | Disordered | ||||
Sequence: PAPVAPIKKPESLSKQKPTAASSESSKELGAASSSAEKEKTKTETQPQKPK | ||||||
Compositional bias | 120-137 | Polar residues | ||||
Sequence: KQKPTAASSESSKELGAA | ||||||
Compositional bias | 138-154 | Basic and acidic residues | ||||
Sequence: SSSAEKEKTKTETQPQK | ||||||
Domain | 164-416 | Protein kinase | ||||
Sequence: FDIGRLLGRGKFGNVYLAREKESQFVVALKVLFKRQIGESNVEHQVRREIEIQSHLRHPHILRLYAYFHDDVRIYLILEYAPQGTLFNALQAQPMKRFDERQSATYIQALCSALLYLHERDIIHRDIKPENLLLGHKGVLKIADFGWSVHEPNSMRMTLCGTVDYLPPEMVQGKPHTKNVDLWSLGVLCFELLVGHAPFYSKNYDETYKKILKVDYKLPEHISKAASHLISKLLVLNPQHRLPLDQVMVHPWI |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length421
- Mass (Da)47,204
- Last updated1996-11-01 v1
- ChecksumDF35F5C78C10D1DC
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-19 | Basic and acidic residues | ||||
Sequence: MSHPSDHVLRPKENAPHRM | ||||||
Compositional bias | 71-93 | Polar residues | ||||
Sequence: KPGLGGSNSIASSEGNNFQKPMV | ||||||
Compositional bias | 120-137 | Polar residues | ||||
Sequence: KQKPTAASSESSKELGAA | ||||||
Compositional bias | 138-154 | Basic and acidic residues | ||||
Sequence: SSSAEKEKTKTETQPQK |