Q27333 · NT56_DROME
- ProteinLethal(2)neighbour of tid protein
- Genel(2)not
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids510 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
Miscellaneous
In strains Harvich and Apxo, there are 2 genes which code for l2not protein. They differ in their C-terminus.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity | |
Biological Process | negative regulation of tumor necrosis factor-mediated signaling pathway | |
Biological Process | protein glycosylation |
Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameLethal(2)neighbour of tid protein
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ27333
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 44-64 | Helical | ||||
Sequence: ALPIVGLFVLLAELVINVVVI | ||||||
Transmembrane | 98-118 | Helical | ||||
Sequence: TGPLVYPAAFVYIYSALYYVT | ||||||
Transmembrane | 126-146 | Helical | ||||
Sequence: LAQYIFAGIYLLQLALVLRLY | ||||||
Transmembrane | 172-192 | Helical | ||||
Sequence: VLRLFNDPVAVLLLYAALNLF | ||||||
Transmembrane | 212-232 | Helical | ||||
Sequence: MNILLFAPALLLFYLANLGLL | ||||||
Transmembrane | 234-254 | Helical | ||||
Sequence: TILQLAVCGVIQLLLGAPFLL | ||||||
Transmembrane | 295-315 | Helical | ||||
Sequence: SLLGLHLLLLLAFAKPIWTFF | ||||||
Transmembrane | 404-424 | Helical | ||||
Sequence: LALLPFFLCNLVGVACSRSLH | ||||||
Transmembrane | 427-447 | Helical | ||||
Sequence: FYVWYFHSLPYLAWSTPYSLG | ||||||
Transmembrane | 465-485 | Helical | ||||
Sequence: STNFSSAALHFTHIILLAGVA |
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 286 | in strain: Berkeley and bIf | ||||
Sequence: V → L | ||||||
Natural variant | 311 | in strain: Berkeley, bIf and Apxo | ||||
Sequence: I → T | ||||||
Natural variant | 333 | in strain: Berkeley, bIf and Apxo | ||||
Sequence: T → A | ||||||
Natural variant | 338 | in strain: Berkeley, bIf and Apxo | ||||
Sequence: Q → E | ||||||
Natural variant | 340 | in strain: Berkeley and bIf | ||||
Sequence: K → N | ||||||
Mutagenesis | 433 | In tid4 mutant. | ||||
Sequence: H → R | ||||||
Natural variant | 489 | in strain: Berkeley, bIf and Apxo | ||||
Sequence: I → V |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 6 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000080568 | 1-510 | Lethal2neighbour of tid protein | |||
Sequence: MAPPKAASHRPAVRRKKSGTLVDSILDKYLNVRFFKYLLLEPAALPIVGLFVLLAELVINVVVIQRVPYTEIDWVAYMQECEGFLNGTTNYSLLRGDTGPLVYPAAFVYIYSALYYVTSHGTNVRLAQYIFAGIYLLQLALVLRLYSKSRKVPPYVLVLSAFTSYRIHSIYVLRLFNDPVAVLLLYAALNLFLDRRWTLGSTFFSLAVGVKMNILLFAPALLLFYLANLGLLRTILQLAVCGVIQLLLGAPFLLTHPVEYLRGSFDLGRIFEHKWTVNYRFLSRDVFENRTFHVSLLGLHLLLLLAFAKPIWTFFQSYVRLRRIEDQLQPQITQQNLQLKAQKRPKKVEKDKDKDQKKFTTEQQSFLKAFEKSLQKASGGKATPAPAQAEPERYGIHFDRCTQLALLPFFLCNLVGVACSRSLHYQFYVWYFHSLPYLAWSTPYSLGVRCLILGLIEYCWNTYPSTNFSSAALHFTHIILLAGVAKQLIQTMRINNAAKREQQEQQKKLQ |
Proteomic databases
Expression
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 337-358 | Disordered | ||||
Sequence: LQLKAQKRPKKVEKDKDKDQKK | ||||||
Compositional bias | 342-358 | Basic and acidic residues | ||||
Sequence: QKRPKKVEKDKDKDQKK |
Sequence similarities
Belongs to the glycosyltransferase 58 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length510
- Mass (Da)58,461
- Last updated1996-11-01 v1
- ChecksumE2F7415940465F25
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 342-358 | Basic and acidic residues | ||||
Sequence: QKRPKKVEKDKDKDQKK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X95241 EMBL· GenBank· DDBJ | CAA64529.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X77820 EMBL· GenBank· DDBJ | CAA54835.1 EMBL· GenBank· DDBJ | mRNA | ||
X95248 EMBL· GenBank· DDBJ | CAA64537.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X95252 EMBL· GenBank· DDBJ | CAA64541.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X95243 EMBL· GenBank· DDBJ | CAA64532.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Y10074 EMBL· GenBank· DDBJ | CAA71167.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X98094 EMBL· GenBank· DDBJ | CAA66721.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE013599 EMBL· GenBank· DDBJ | AAF47050.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY061582 EMBL· GenBank· DDBJ | AAL29130.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |