Q27333 · NT56_DROME

Function

Miscellaneous

In strains Harvich and Apxo, there are 2 genes which code for l2not protein. They differ in their C-terminus.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentendoplasmic reticulum membrane
Molecular Functiondol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity
Biological Processnegative regulation of tumor necrosis factor-mediated signaling pathway
Biological Processprotein glycosylation

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Lethal(2)neighbour of tid protein
  • Alternative names
    • NOT45
    • NOT56

Gene names

    • Name
      l(2)not
    • ORF names
      CG4084

Organism names

  • Taxonomic identifier
  • Strains
    • Apxo
    • bIf
    • Harvich
    • Oregon-R
    • Oregon-2
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q27333
  • Secondary accessions
    • O02532
    • O02533
    • Q24419
    • Q24420
    • Q24421

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane44-64Helical
Transmembrane98-118Helical
Transmembrane126-146Helical
Transmembrane172-192Helical
Transmembrane212-232Helical
Transmembrane234-254Helical
Transmembrane295-315Helical
Transmembrane404-424Helical
Transmembrane427-447Helical
Transmembrane465-485Helical

Keywords

Phenotypes & Variants

Features

Showing features for natural variant, mutagenesis.

TypeIDPosition(s)Description
Natural variant286in strain: Berkeley and bIf
Natural variant311in strain: Berkeley, bIf and Apxo
Natural variant333in strain: Berkeley, bIf and Apxo
Natural variant338in strain: Berkeley, bIf and Apxo
Natural variant340in strain: Berkeley and bIf
Mutagenesis433In tid4 mutant.
Natural variant489in strain: Berkeley, bIf and Apxo

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 6 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000805681-510Lethal2neighbour of tid protein

Proteomic databases

Expression

Developmental stage

Expressed only in embryos.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region337-358Disordered
Compositional bias342-358Basic and acidic residues

Sequence similarities

Belongs to the glycosyltransferase 58 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    510
  • Mass (Da)
    58,461
  • Last updated
    1996-11-01 v1
  • Checksum
    E2F7415940465F25
MAPPKAASHRPAVRRKKSGTLVDSILDKYLNVRFFKYLLLEPAALPIVGLFVLLAELVINVVVIQRVPYTEIDWVAYMQECEGFLNGTTNYSLLRGDTGPLVYPAAFVYIYSALYYVTSHGTNVRLAQYIFAGIYLLQLALVLRLYSKSRKVPPYVLVLSAFTSYRIHSIYVLRLFNDPVAVLLLYAALNLFLDRRWTLGSTFFSLAVGVKMNILLFAPALLLFYLANLGLLRTILQLAVCGVIQLLLGAPFLLTHPVEYLRGSFDLGRIFEHKWTVNYRFLSRDVFENRTFHVSLLGLHLLLLLAFAKPIWTFFQSYVRLRRIEDQLQPQITQQNLQLKAQKRPKKVEKDKDKDQKKFTTEQQSFLKAFEKSLQKASGGKATPAPAQAEPERYGIHFDRCTQLALLPFFLCNLVGVACSRSLHYQFYVWYFHSLPYLAWSTPYSLGVRCLILGLIEYCWNTYPSTNFSSAALHFTHIILLAGVAKQLIQTMRINNAAKREQQEQQKKLQ

Sequence caution

The sequence AAL29130.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias342-358Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X95241
EMBL· GenBank· DDBJ
CAA64529.1
EMBL· GenBank· DDBJ
Genomic DNA
X77820
EMBL· GenBank· DDBJ
CAA54835.1
EMBL· GenBank· DDBJ
mRNA
X95248
EMBL· GenBank· DDBJ
CAA64537.1
EMBL· GenBank· DDBJ
Genomic DNA
X95252
EMBL· GenBank· DDBJ
CAA64541.1
EMBL· GenBank· DDBJ
Genomic DNA
X95243
EMBL· GenBank· DDBJ
CAA64532.1
EMBL· GenBank· DDBJ
Genomic DNA
Y10074
EMBL· GenBank· DDBJ
CAA71167.1
EMBL· GenBank· DDBJ
Genomic DNA
X98094
EMBL· GenBank· DDBJ
CAA66721.1
EMBL· GenBank· DDBJ
Genomic DNA
AE013599
EMBL· GenBank· DDBJ
AAF47050.1
EMBL· GenBank· DDBJ
Genomic DNA
AY061582
EMBL· GenBank· DDBJ
AAL29130.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

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