Q27203 · HPPD_TETTH
- Protein4-hydroxyphenylpyruvate dioxygenase
- GeneTFA
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids404 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Key enzyme in the degradation of tyrosine.
Catalytic activity
- 3-(4-hydroxyphenyl)pyruvate + O2 = homogentisate + CO2
Cofactor
Note: Binds 1 Fe cation per subunit.
Pathway
Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 4-hydroxyphenylpyruvate dioxygenase activity | |
Molecular Function | metal ion binding | |
Biological Process | L-phenylalanine catabolic process | |
Biological Process | tyrosine catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-hydroxyphenylpyruvate dioxygenase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Ciliophora > Intramacronucleata > Oligohymenophorea > Hymenostomatida > Tetrahymenina > Tetrahymenidae > Tetrahymena
Accessions
- Primary accessionQ27203
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000088396 | 1-404 | 4-hydroxyphenylpyruvate dioxygenase | |||
Sequence: MSENKDHVVVGYTEKPVGERPTGGKFLGYDHLHFWVGNAKQAAGWYTSRFGFEYYAYKGLETGSREVATHVVRNKQGVTLAFSTPYGNDKDNQREMNQHQSLHGDGVKDVAFAVEDCHSIYNKAIQRGAKCAYPPQDLKDEHGSVTIAAVHTYGEVIHTFIQRNDYKGFFMPGFVAHPLKDPLNNVLPDISYNYVDHIVGNQPDNMMTSAADWYEKTLDFHRFWSVDDSMIHTEFSSLRSIVMTDYDQKIKMPINEPADGKRKSQIQEYIDFYAGPGVQHIALNTSDVINTVEGLRARGVEFLSIPTSYYDNLRKALTAQTSITVKEDLDVLQKNHILVDYDEKGYLLQIFTKPVEDRPTLFYEIIQRNNHQGFGAGNFKSLFVSLELEQEKRGNLTEIVKNIY |
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 28-163 | VOC 1 | ||||
Sequence: GYDHLHFWVGNAKQAAGWYTSRFGFEYYAYKGLETGSREVATHVVRNKQGVTLAFSTPYGNDKDNQREMNQHQSLHGDGVKDVAFAVEDCHSIYNKAIQRGAKCAYPPQDLKDEHGSVTIAAVHTYGEVIHTFIQR | ||||||
Domain | 194-353 | VOC 2 | ||||
Sequence: YVDHIVGNQPDNMMTSAADWYEKTLDFHRFWSVDDSMIHTEFSSLRSIVMTDYDQKIKMPINEPADGKRKSQIQEYIDFYAGPGVQHIALNTSDVINTVEGLRARGVEFLSIPTSYYDNLRKALTAQTSITVKEDLDVLQKNHILVDYDEKGYLLQIFTK |
Sequence similarities
Belongs to the 4HPPD family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length404
- Mass (Da)46,046
- Last updated1996-11-01 v1
- Checksum48DADC8AEE5D1837