Q27203 · HPPD_TETTH

  • Protein
    4-hydroxyphenylpyruvate dioxygenase
  • Gene
    TFA
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Key enzyme in the degradation of tyrosine.

Catalytic activity

Cofactor

Fe cation (UniProtKB | Rhea| CHEBI:24875 )

Note: Binds 1 Fe cation per subunit.

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.

Features

Showing features for binding site.

140450100150200250300350400
TypeIDPosition(s)Description
Binding site197Fe cation (UniProtKB | ChEBI)
Binding site280Fe cation (UniProtKB | ChEBI)
Binding site364Fe cation (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4-hydroxyphenylpyruvate dioxygenase activity
Molecular Functionmetal ion binding
Biological ProcessL-phenylalanine catabolic process
Biological Processtyrosine catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxyphenylpyruvate dioxygenase
  • EC number
  • Alternative names
    • 4-hydroxyphenylpyruvic acid oxidase (4HPPD; HPD; HPPDase)
    • F-antigen homolog
    • TF-AG

Gene names

    • Name
      TFA

Organism names

  • Taxonomic identifier
  • Strain
    • B1868
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Ciliophora > Intramacronucleata > Oligohymenophorea > Hymenostomatida > Tetrahymenina > Tetrahymenidae > Tetrahymena

Accessions

  • Primary accession
    Q27203

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000883961-4044-hydroxyphenylpyruvate dioxygenase

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain28-163VOC 1
Domain194-353VOC 2

Sequence similarities

Belongs to the 4HPPD family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    404
  • Mass (Da)
    46,046
  • Last updated
    1996-11-01 v1
  • Checksum
    48DADC8AEE5D1837
MSENKDHVVVGYTEKPVGERPTGGKFLGYDHLHFWVGNAKQAAGWYTSRFGFEYYAYKGLETGSREVATHVVRNKQGVTLAFSTPYGNDKDNQREMNQHQSLHGDGVKDVAFAVEDCHSIYNKAIQRGAKCAYPPQDLKDEHGSVTIAAVHTYGEVIHTFIQRNDYKGFFMPGFVAHPLKDPLNNVLPDISYNYVDHIVGNQPDNMMTSAADWYEKTLDFHRFWSVDDSMIHTEFSSLRSIVMTDYDQKIKMPINEPADGKRKSQIQEYIDFYAGPGVQHIALNTSDVINTVEGLRARGVEFLSIPTSYYDNLRKALTAQTSITVKEDLDVLQKNHILVDYDEKGYLLQIFTKPVEDRPTLFYEIIQRNNHQGFGAGNFKSLFVSLELEQEKRGNLTEIVKNIY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M59429
EMBL· GenBank· DDBJ
AAA96492.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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