Q26268 · Q26268_APLCA
- ProteinCalreticulin
- Genecalreticulin
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids405 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum lumen | |
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | unfolded protein binding | |
Biological Process | protein folding |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCalreticulin
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Spiralia > Lophotrochozoa > Mollusca > Gastropoda > Heterobranchia > Euthyneura > Tectipleura > Aplysiida > Aplysioidea > Aplysiidae > Aplysia
Accessions
- Primary accessionQ26268
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-15 | |||||
Sequence: MKVVLLCALLGIAFA | ||||||
Chain | PRO_5012113302 | 16-405 | Calreticulin | |||
Sequence: DPTVYFKEEFGDDWAERWVESKHKSDLGKFVLTAGKFYGDAEKDKGIQTSQDARFYGLSAKFDKFSNEGKTLVIQFTVKHEQNIDCGGGYVKVFSSDLDQSDMHGESPYNIMFGPDICGPGTKKVHVIFNYKGKNLLVKKDIRCKDDVFSHLYTLIVRPDNTYEVKIDNEKAESGDLEADWDFLPAKTIPDPDAKKPDDWDEREKIDDPDDTKPEDWDKPEHIPDPEAKKPDDWDDEMDGEWEPPMIDNPEYKGEWKPKQVDNPDYKGKWVHPEIDNPEYEADDKLYSFADFGAIGFDLWQVKAGTIFDNVLITDSVEYAEEFGNETWGKTKDPEKKMKDAQDEEDRKAREEEEKKRKEEEDANKDDEEEEAEEEEEEEDDDAAPEKDEL | ||||||
Disulfide bond | 101↔133 | |||||
Sequence: CGGGYVKVFSSDLDQSDMHGESPYNIMFGPDIC |
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 193-285 | Disordered | ||||
Sequence: EADWDFLPAKTIPDPDAKKPDDWDEREKIDDPDDTKPEDWDKPEHIPDPEAKKPDDWDDEMDGEWEPPMIDNPEYKGEWKPKQVDNPDYKGKW | ||||||
Compositional bias | 204-250 | Basic and acidic residues | ||||
Sequence: IPDPDAKKPDDWDEREKIDDPDDTKPEDWDKPEHIPDPEAKKPDDWD | ||||||
Compositional bias | 261-285 | Basic and acidic residues | ||||
Sequence: MIDNPEYKGEWKPKQVDNPDYKGKW | ||||||
Region | 339-405 | Disordered | ||||
Sequence: GNETWGKTKDPEKKMKDAQDEEDRKAREEEEKKRKEEEDANKDDEEEEAEEEEEEEDDDAAPEKDEL | ||||||
Compositional bias | 340-378 | Basic and acidic residues | ||||
Sequence: NETWGKTKDPEKKMKDAQDEEDRKAREEEEKKRKEEEDA | ||||||
Compositional bias | 379-405 | Acidic residues | ||||
Sequence: NKDDEEEEAEEEEEEEDDDAAPEKDEL |
Sequence similarities
Belongs to the calreticulin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length405
- Mass (Da)46,738
- Last updated1996-11-01 v1
- Checksum14CAA201840D1D69
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 204-250 | Basic and acidic residues | ||||
Sequence: IPDPDAKKPDDWDEREKIDDPDDTKPEDWDKPEHIPDPEAKKPDDWD | ||||||
Compositional bias | 261-285 | Basic and acidic residues | ||||
Sequence: MIDNPEYKGEWKPKQVDNPDYKGKW | ||||||
Compositional bias | 340-378 | Basic and acidic residues | ||||
Sequence: NETWGKTKDPEKKMKDAQDEEDRKAREEEEKKRKEEEDA | ||||||
Compositional bias | 379-405 | Acidic residues | ||||
Sequence: NKDDEEEEAEEEEEEEDDDAAPEKDEL |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
S51239 EMBL· GenBank· DDBJ | AAB24569.1 EMBL· GenBank· DDBJ | mRNA |