Q26240 · NOS_RHOPR

Function

function

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. The production of NO in the salivary gland is used as a vasodilator for blood sucking.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
heme b (UniProtKB | Rhea| CHEBI:60344 )

FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD.
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN.

Activity regulation

Stimulated by calcium/calmodulin.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site83(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (UniProtKB | ChEBI)
Binding site162Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue
Binding site225L-arginine (UniProtKB | ChEBI)
Binding site334L-arginine (UniProtKB | ChEBI)
Binding site335L-arginine (UniProtKB | ChEBI)
Binding site339L-arginine (UniProtKB | ChEBI)
Binding site344L-arginine (UniProtKB | ChEBI)
Binding site425(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (UniProtKB | ChEBI)
Binding site438(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (UniProtKB | ChEBI)
Binding site453heme b (UniProtKB | ChEBI)
Binding site639-670FMN (UniProtKB | ChEBI)
Binding site780-791FAD (UniProtKB | ChEBI)
Binding site923-933FAD (UniProtKB | ChEBI)
Binding site998-1016NADP+ (UniProtKB | ChEBI)
Binding site1095-1110NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functioncalmodulin binding
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionFMN binding
Molecular Functionheme binding
Molecular Functionmetal ion binding
Molecular FunctionNADP binding
Molecular Functionnitric-oxide synthase activity
Biological Processnitric oxide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Nitric oxide synthase, salivary gland
  • EC number
  • Short names
    NOS

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Paraneoptera > Hemiptera > Heteroptera > Panheteroptera > Cimicomorpha > Reduviidae > Triatominae > Rhodnius

Accessions

  • Primary accession
    Q26240

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001709521-1174Nitric oxide synthase, salivary gland

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region475-495Calmodulin-binding
Domain505-693Flavodoxin-like
Domain745-990FAD-binding FR-type

Sequence similarities

Belongs to the NOS family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,174
  • Mass (Da)
    132,393
  • Last updated
    1996-11-01 v1
  • Checksum
    C32F664EE51409CF
MVHAECVWWLGIRILFVPPVSLEMHSVNVNNMSIQQQQQHQPQQQLLKPIRLANVSTQAQSLDTLHYKCQQEGPCMEQACLASVIYAGVNLKPRVRPKEELLAHAKDFLDQYFASIRRLQSPAHEARWAQVEKEVAATGTYELTETELVYGAKLAWRNAPRCIGRIQWAKLQVFDCRQVTTTSGMFEALCNHIKYSTNKGNIRSAITIFPHRTDGKHDFRIWNKQLISYAGHKSKDGTVIGDPACVEFTEICIKLGWKGKGTMFDVLPLVLSANGEDPDYFDLPPELVFEVPLSHPKYKWFSELGLKWFALPAVSGMMFDCGGLQFTAAPFNGWYMNSEIGSRNLGDTNRYNMLEKIAQKMELDTRTPVTLWKDLAMVEANVAVLHSFQLHNVTIVDHHSAAESFMKHLENEQRLRGGCPADWVWIVPPISGSATPVFFQEMANYFLYPGYIYQEDAWKCHEWKEIDVKHGLKKEKRKFHFKQIARAVKFTSKLFGSALSKRIKATILFATETGKSEMYARKLGDIFSHAFHSQVLSMEDYDMSKIEHEALLLVVASTFGNGDPPENGQGFAQSLYTIKMDENGLPNGHTNNTLASSASFIKANSQTDRQASLERCDSFRGSTGDADVFGPLSNVRFAVFALGSSAYPNFCAFGSYVDNLLGELGGERLVKLTTGDEMCGQAQACNKWAPEVFSVACDTFCLDSDETFLEATQMLHSEAVTASTVRFVESATQDLCKALSHLHNKKVWKCPLLGKRNLHGKGSTRATLLLEIERNENISYQPGDHVGVLACNRKELVEGIISHLESAIDPDKSVQLQILKENTTPDGIVRNWIPHDRLPTCSLRTMLTRFLDITTPPSPNLLQFFASCATNSEDQEKLTELATDSAAYEDWRYWKYPNLLEVLEEFPSVRVLPALLIAQLTPLQPRFYSISSAPSLYANQIHLTVAVVQYCTQDGKGPIHYGVASNYLYDVTIGDSIYLFTRSAPNFHLPKSDTAPIIMVGPGTGIAPFRGFWQHRLAQRSLNGPGKFGKMSLFFGCRLRNLDLYQEEKESMLKEGILSKVFLALSREPSIPKTYVQDLLRVECKSVYIQIVQEGGHFYVCGDCTMAEHVFRTLRQIIQDQGNMTDHQVDNFMLAMRDENRYHEDIFGITLRTAEVHNRSRESARIRMASQSQP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U59389
EMBL· GenBank· DDBJ
AAB03810.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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