Q256B8 · PCKG_CHLFF

Function

function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mn2+ ion per subunit.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site76substrate
Binding site216-218substrate
Binding site225Mn2+ (UniProtKB | ChEBI)
Binding site245Mn2+ (UniProtKB | ChEBI)
Binding site267substrate
Binding site268-273GTP (UniProtKB | ChEBI)
Active site269
Binding site292Mn2+ (UniProtKB | ChEBI)
Binding site381-383substrate
Binding site383GTP (UniProtKB | ChEBI)
Binding site414GTP (UniProtKB | ChEBI)
Binding site508-511GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionGTP binding
Molecular Functionmanganese ion binding
Molecular Functionphosphoenolpyruvate carboxykinase (GTP) activity
Biological Processgluconeogenesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoenolpyruvate carboxykinase [GTP]
  • EC number
  • Short names
    PEP carboxykinase
    ; PEPCK

Gene names

    • Name
      pckG
    • Ordered locus names
      CF0098

Organism names

Accessions

  • Primary accession
    Q256B8

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000809841-600Phosphoenolpyruvate carboxykinase [GTP]

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    600
  • Mass (Da)
    66,477
  • Last updated
    2006-04-18 v1
  • Checksum
    52F3231C978B8B74
MTSAWSNEIQHEGLKQWIQEVAELVTPEDIRVCNGSDSEYAEVYSIMQKSGVAIPLNSDLHPNCFLVRSSPEDVARVEKFTFICTAKKEEAGPTNNWRDPQEMRQELQGLFRGCMRGRTLYVVPFCMGPLNSPFSLIGVELTDSPYVVCSMKIMTRMGAEVLKSLGTSGTFHKCLHSVGVPLSPGEKDVAWPCNPEHMRIVHFQDDSSVMSFGSGYGGNALLGKKCVALRLASYIARSKNWLAEHMLIIGVTNPEGQKKYFAASFPSACGKTNLAMLKPKIPGWKIECIGDDIAWIRPGSDGRLYAVNPEYGFFGVAPGTSEKTNPNALATCRSNSIFTNVALTPDGDVWWEGLTSQPPAGLIDWRGNPWQPGGTPAAHPNSRFTTPLQQCPVLDSQWNSSEGVPLEAIIFGGRRSDTIPLVYEALSWQHGVTIGASMSSATTAAIVGEQGKLRHDPFAMLPFCGYNMALYFDHWLSFASNASLKLPKIYGVNWFRKDKDGNFIWPGFSENLRVLEWIFRRTNGEESIAKRTPIGYLPEESSLNLEGLNLSSQALQDLLAVDVPGWLKEVADVREYCKIFGSDLPQIISDELFRIERELK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP006861
EMBL· GenBank· DDBJ
BAE80870.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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