Q25637 · PER_PERAM

Function

function

Involved in the generation of biological rhythms. The biological cycle depends on the rhythmic formation and nuclear localization of the tim-per complex. Light induces the degradation of tim, which promotes elimination of per. Nuclear activity of the heterodimer coordinatively regulates per and tim transcription negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functiontranscription cis-regulatory region binding
Molecular Functiontranscription corepressor binding
Biological Processcircadian regulation of gene expression
Biological Processentrainment of circadian clock by photoperiod
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processpositive regulation of metabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Period circadian protein

Gene names

    • Name
      per

Organism names

Accessions

  • Primary accession
    Q25637

Subcellular Location

Note: Nuclear at specific periods of the day. Interaction with TIM is required for nuclear localization (By similarity).

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001626231-893Period circadian protein

Post-translational modification

Phosphorylated with a circadian rhythmicity.

Keywords

Interaction

Subunit

Forms a heterodimer with timeless (TIM); the complex then translocates into the nucleus.

Structure

Family & Domains

Features

Showing features for region, compositional bias, motif, domain.

TypeIDPosition(s)Description
Region1-83Disordered
Compositional bias8-63Polar residues
Motif66-77Nuclear localization signal
Domain228-371PAS 1
Domain390-493PAS 2
Region592-614Disordered
Region645-716Disordered
Compositional bias659-713Polar residues
Region731-751Disordered
Region784-803Disordered

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    893
  • Mass (Da)
    97,174
  • Last updated
    2000-12-01 v2
  • Checksum
    28AA2AA54E4DA61F
MEETATHNTKISDSAYSNSSNSQSQRSSGSSKSRHSNSSGSSGYCGHGSSIQGSSNEPFPQPSVTKRNKDKEHKKKKLKSSVTTAATATVTSVVTTVSEYTEHENGTSHMSLGVSGTVVPLSGTVAEETEITEAGSEGSVISSHAGVALGAAGVVPATTPGPENEAHQMASLTQTLNSIKKMKKMKDLSTDIPEETEGHSFSLPMVAEEKEEHIRNSFDAEPPAHNEGEFCVVVSMQDGVVVFTTPSITDVVGFPKDMWLGRSFIDFVHPRDRTAFANHITSGVITPLSNSNPKGGSHPGKNSFYCCLRRYRGLKSTGYGVTEKEVSYLPFQLNMTFRELLPHSNPLEVEGNTSPESVPGGCNSMFLVITAKLICSAYKHAGETCASPKFVTRHLATCKLNYVDPECMPYLGYLPHEMLGNSVLDFYHPEDLPFLKEVYQIVMQENGAPFRSKPYRFRSHNGGYILLETEWSSFVNPWSKKLEFVVGQHRVLKGPENADVFMAPVEDDTLQISEEVLKESKIIQEEIRSLLSEMVKNNGHLEKQQMSKRCRDLATFMESLMDDITKPDLKLELPQEEHSFSEHDSVMLGEISPHHDYYDSKSSTETPPSYNQLNYNDNIQRFFESKPKTTLSDESGESKIEANRSLMSTDEEGKSGPAADSSLGSSNRKCCSPVNGSGSGSGSGHSSGSAGIGGSAESRRDTSATNTSHGSYKPPLLTEALLCRHNEDMEKKMVQKHREQRNKGSERESKLKKCVHDKLLQEQCHGVKRSGSHSWEGEVYKASKHPHVEGGKELNPGSGGSGGGGVTSGLSQCLGVAATGKQYSGVGSVPPIFQGGTNVNLWPPFSVTVTPLQPTPPCSTHGFATNNIPTPPHMASMIPVYYIEKRAPNFKNN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias8-63Polar residues
Compositional bias659-713Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U12772
EMBL· GenBank· DDBJ
AAA64677.2
EMBL· GenBank· DDBJ
mRNA

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