Q25637 · PER_PERAM
- ProteinPeriod circadian protein
- Geneper
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids893 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Involved in the generation of biological rhythms. The biological cycle depends on the rhythmic formation and nuclear localization of the tim-per complex. Light induces the degradation of tim, which promotes elimination of per. Nuclear activity of the heterodimer coordinatively regulates per and tim transcription negative feedback loop. Behaves as a negative element in circadian transcriptional loop. Does not appear to bind DNA, suggesting indirect transcriptional inhibition (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | transcription cis-regulatory region binding | |
Molecular Function | transcription corepressor binding | |
Biological Process | circadian regulation of gene expression | |
Biological Process | entrainment of circadian clock by photoperiod | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | positive regulation of metabolic process |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended namePeriod circadian protein
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Polyneoptera > Dictyoptera > Blattodea > Blattoidea > Blattidae > Blattinae > Periplaneta
Accessions
- Primary accessionQ25637
Subcellular Location
UniProt Annotation
GO Annotation
Note: Nuclear at specific periods of the day. Interaction with TIM is required for nuclear localization (By similarity).
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000162623 | 1-893 | Period circadian protein | |||
Sequence: MEETATHNTKISDSAYSNSSNSQSQRSSGSSKSRHSNSSGSSGYCGHGSSIQGSSNEPFPQPSVTKRNKDKEHKKKKLKSSVTTAATATVTSVVTTVSEYTEHENGTSHMSLGVSGTVVPLSGTVAEETEITEAGSEGSVISSHAGVALGAAGVVPATTPGPENEAHQMASLTQTLNSIKKMKKMKDLSTDIPEETEGHSFSLPMVAEEKEEHIRNSFDAEPPAHNEGEFCVVVSMQDGVVVFTTPSITDVVGFPKDMWLGRSFIDFVHPRDRTAFANHITSGVITPLSNSNPKGGSHPGKNSFYCCLRRYRGLKSTGYGVTEKEVSYLPFQLNMTFRELLPHSNPLEVEGNTSPESVPGGCNSMFLVITAKLICSAYKHAGETCASPKFVTRHLATCKLNYVDPECMPYLGYLPHEMLGNSVLDFYHPEDLPFLKEVYQIVMQENGAPFRSKPYRFRSHNGGYILLETEWSSFVNPWSKKLEFVVGQHRVLKGPENADVFMAPVEDDTLQISEEVLKESKIIQEEIRSLLSEMVKNNGHLEKQQMSKRCRDLATFMESLMDDITKPDLKLELPQEEHSFSEHDSVMLGEISPHHDYYDSKSSTETPPSYNQLNYNDNIQRFFESKPKTTLSDESGESKIEANRSLMSTDEEGKSGPAADSSLGSSNRKCCSPVNGSGSGSGSGHSSGSAGIGGSAESRRDTSATNTSHGSYKPPLLTEALLCRHNEDMEKKMVQKHREQRNKGSERESKLKKCVHDKLLQEQCHGVKRSGSHSWEGEVYKASKHPHVEGGKELNPGSGGSGGGGVTSGLSQCLGVAATGKQYSGVGSVPPIFQGGTNVNLWPPFSVTVTPLQPTPPCSTHGFATNNIPTPPHMASMIPVYYIEKRAPNFKNN |
Post-translational modification
Phosphorylated with a circadian rhythmicity.
Keywords
- PTM
Interaction
Subunit
Forms a heterodimer with timeless (TIM); the complex then translocates into the nucleus.
Structure
Family & Domains
Features
Showing features for region, compositional bias, motif, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-83 | Disordered | ||||
Sequence: MEETATHNTKISDSAYSNSSNSQSQRSSGSSKSRHSNSSGSSGYCGHGSSIQGSSNEPFPQPSVTKRNKDKEHKKKKLKSSVT | ||||||
Compositional bias | 8-63 | Polar residues | ||||
Sequence: NTKISDSAYSNSSNSQSQRSSGSSKSRHSNSSGSSGYCGHGSSIQGSSNEPFPQPS | ||||||
Motif | 66-77 | Nuclear localization signal | ||||
Sequence: KRNKDKEHKKKK | ||||||
Domain | 228-371 | PAS 1 | ||||
Sequence: GEFCVVVSMQDGVVVFTTPSITDVVGFPKDMWLGRSFIDFVHPRDRTAFANHITSGVITPLSNSNPKGGSHPGKNSFYCCLRRYRGLKSTGYGVTEKEVSYLPFQLNMTFRELLPHSNPLEVEGNTSPESVPGGCNSMFLVITA | ||||||
Domain | 390-493 | PAS 2 | ||||
Sequence: FVTRHLATCKLNYVDPECMPYLGYLPHEMLGNSVLDFYHPEDLPFLKEVYQIVMQENGAPFRSKPYRFRSHNGGYILLETEWSSFVNPWSKKLEFVVGQHRVLK | ||||||
Region | 592-614 | Disordered | ||||
Sequence: SPHHDYYDSKSSTETPPSYNQLN | ||||||
Region | 645-716 | Disordered | ||||
Sequence: SLMSTDEEGKSGPAADSSLGSSNRKCCSPVNGSGSGSGSGHSSGSAGIGGSAESRRDTSATNTSHGSYKPPL | ||||||
Compositional bias | 659-713 | Polar residues | ||||
Sequence: ADSSLGSSNRKCCSPVNGSGSGSGSGHSSGSAGIGGSAESRRDTSATNTSHGSYK | ||||||
Region | 731-751 | Disordered | ||||
Sequence: KKMVQKHREQRNKGSERESKL | ||||||
Region | 784-803 | Disordered | ||||
Sequence: KHPHVEGGKELNPGSGGSGG |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length893
- Mass (Da)97,174
- Last updated2000-12-01 v2
- Checksum28AA2AA54E4DA61F
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 8-63 | Polar residues | ||||
Sequence: NTKISDSAYSNSSNSQSQRSSGSSKSRHSNSSGSSGYCGHGSSIQGSSNEPFPQPS | ||||||
Compositional bias | 659-713 | Polar residues | ||||
Sequence: ADSSLGSSNRKCCSPVNGSGSGSGSGHSSGSAGIGGSAESRRDTSATNTSHGSYK |