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Q254E0 · Q254E0_CHLFF

Function

function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.

Catalytic activity

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.

Features

Showing features for binding site, active site.

148150100150200250300350400450
Type
IDPosition(s)Description
Binding site11-16NADP+ (UniProtKB | ChEBI)
Binding site34-36NADP+ (UniProtKB | ChEBI)
Binding site76-78NADP+ (UniProtKB | ChEBI)
Binding site104NADP+ (UniProtKB | ChEBI)
Binding site104substrate; ligand shared between dimeric partners; in other chain
Binding site130-132substrate; ligand shared between dimeric partners; in other chain
Active site184Proton acceptor
Binding site187-188substrate; ligand shared between dimeric partners; in other chain
Active site191Proton donor
Binding site192substrate; ligand shared between dimeric partners; in other chain
Binding site261substrate; ligand shared between dimeric partners; in other chain
Binding site288substrate; ligand shared between dimeric partners; in other chain
Binding site448substrate; ligand shared between dimeric partners
Binding site454substrate; ligand shared between dimeric partners

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionNADP binding
Molecular Functionphosphogluconate dehydrogenase (decarboxylating) activity
Biological ProcessD-gluconate catabolic process
Biological Processpentose-phosphate shunt, oxidative branch

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    6-phosphogluconate dehydrogenase, decarboxylating
  • EC number

Gene names

    • Name
      gnd
    • Ordered locus names
      CF0576

Organism names

Accessions

  • Primary accession
    Q254E0

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain180-4726-phosphogluconate dehydrogenase C-terminal

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    481
  • Mass (Da)
    53,238
  • Last updated
    2006-04-18 v1
  • MD5 Checksum
    5724C9C967B1D5CB651997879E191F12
MAEQADIGLIGLAVMGKNLVLNMIDHGFSVSVYNRSPEKTREFLQDHSHNISLQGHENLEAFVRSLKRPRKVMLMIKAGAPVDQSIESLLPYLEAGDIIIDGGNSYYRDSERRCQDLKGKGILFIGMGISGGEEGARYGPSIMPGGNSDAWPHIASIFQGIAAKVNGNPCCSWVGPGGAGHYVKTVHNGIEYGDIQLICEAYGLLRTRLDISPEAVSSIFSEWNSRELESYLMRIAVEVLSLKDSDGFPVIDTILDVAGQKGTGRWTALDAIDSGVPLSLIIESVLARFLSSWKTIREQAARELPGIPIVFEKPRDPHLFIEDVFRALYASKIVSYAQGFMLLKQASEEHQWDLNFGELALLWRGGCIIQSVFLDAIHKGFEKEPESPSLILQTYFKSALQNSESGWRRTVAYAVGSGYPVPCLAAALTFYDGYRTKDSSIALAQGLRDYFGAHTYERKDRPRGEFYHTDWIGTKTTTLVE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP006861
EMBL· GenBank· DDBJ
BAE81348.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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