Q254E0 · Q254E0_CHLFF
- Protein6-phosphogluconate dehydrogenase, decarboxylating
- Genegnd
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids481 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.
Catalytic activity
- 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH
Pathway
Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 11-16 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 34-36 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 76-78 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 104 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 104 | substrate; ligand shared between dimeric partners; in other chain | |||
Binding site | 130-132 | substrate; ligand shared between dimeric partners; in other chain | |||
Active site | 184 | Proton acceptor | |||
Binding site | 187-188 | substrate; ligand shared between dimeric partners; in other chain | |||
Active site | 191 | Proton donor | |||
Binding site | 192 | substrate; ligand shared between dimeric partners; in other chain | |||
Binding site | 261 | substrate; ligand shared between dimeric partners; in other chain | |||
Binding site | 288 | substrate; ligand shared between dimeric partners; in other chain | |||
Binding site | 448 | substrate; ligand shared between dimeric partners | |||
Binding site | 454 | substrate; ligand shared between dimeric partners | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | NADP binding | |
Molecular Function | phosphogluconate dehydrogenase (decarboxylating) activity | |
Biological Process | D-gluconate catabolic process | |
Biological Process | pentose-phosphate shunt, oxidative branch |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name6-phosphogluconate dehydrogenase, decarboxylating
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Chlamydiota > Chlamydiia > Chlamydiales > Chlamydiaceae > Chlamydia/Chlamydophila group > Chlamydia
Accessions
- Primary accessionQ254E0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 180-472 | 6-phosphogluconate dehydrogenase C-terminal | |||
Sequence similarities
Belongs to the 6-phosphogluconate dehydrogenase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length481
- Mass (Da)53,238
- Last updated2006-04-18 v1
- MD5 Checksum5724C9C967B1D5CB651997879E191F12
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP006861 EMBL· GenBank· DDBJ | BAE81348.1 EMBL· GenBank· DDBJ | Genomic DNA |