Q25489 · HYEP_MANSE
- ProteinJuvenile hormone epoxide hydrolase
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids462 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Catalyzes juvenile hormone hydrolysis.
Catalytic activity
- cis-stilbene oxide + H2O = (1R,2R)-hydrobenzoin
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 227 | Nucleophile | ||||
Sequence: D | ||||||
Active site | 372 | Proton donor | ||||
Sequence: Y | ||||||
Active site | 428 | Proton acceptor | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | cis-stilbene-oxide hydrolase activity | |
Biological Process | catabolic process | |
Biological Process | epoxide metabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameJuvenile hormone epoxide hydrolase
- EC number
- Short namesJHEH
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Lepidoptera > Glossata > Ditrysia > Bombycoidea > Sphingidae > Sphinginae > Sphingini > Manduca
Accessions
- Primary accessionQ25489
Subcellular Location
UniProt Annotation
GO Annotation
Microsome membrane ; Single-pass membrane protein
Endoplasmic reticulum membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 4-24 | Helical | ||||
Sequence: ILSSFVAGVAIGSGLVITYVL |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000080862 | 1-462 | Juvenile hormone epoxide hydrolase | |||
Sequence: MYKILSSFVAGVAIGSGLVITYVLYNVPEPPELDLQRWWGIGTRPTEEDKSIRPFSIDFNDTVILDLKERLKNRRPFTKPLEGINSEYGMNTEYLETVLEYWLNEYNFKKRAELLNKFPHYKTRIQGLDLHFIRVKPEIKEGVQVLPLLMMHGWPSSSKEFDKVIPILTTPKHEYNIVFEVVAVDLPGYGFSEGTNKPGLNPVQIGVMMRNLMLRLGFEKFYIQAGDWGSQCATHMATLFPDQVLGLHTNMPLSSRPLSTVKLFIGALFPSLIVDAKYMDRIYPLKNLFSYILRETGYFHIQATKPDTIGVALTDSPAGLAGYLIEKMAICSNRDQLDTPHGGLENLNLDDVLDTVTINWINNCIVTSTRLYAEGFSWPEVLIVHRIPSMVPTAGINFKYEVLYQPDWILRDKFPNLVRSTVLDFGGHFAALHTPQALADDIFASAVQFLKFHDRKRNQKSS |
Interaction
Chemistry
Structure
Sequence
- Sequence statusComplete
- Length462
- Mass (Da)52,612
- Last updated1996-11-01 v1
- Checksum667D1A66C2EE430B
Keywords
- Technical term