Q24UJ4 · PNP_DESHY

Function

function

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

1727100200300400500600700
TypeIDPosition(s)Description
Binding site491Mg2+ (UniProtKB | ChEBI)
Binding site497Mg2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Molecular Function3'-5'-RNA exonuclease activity
Molecular Functionmagnesium ion binding
Molecular Functionpolyribonucleotide nucleotidyltransferase activity
Molecular FunctionRNA binding
Biological ProcessmRNA catabolic process
Biological ProcessRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Polyribonucleotide nucleotidyltransferase
  • EC number
  • Alternative names
    • Polynucleotide phosphorylase
      (PNPase
      )

Gene names

    • Name
      pnp
    • Ordered locus names
      DSY2509

Organism names

Accessions

  • Primary accession
    Q24UJ4

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003296221-727Polyribonucleotide nucleotidyltransferase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain558-617KH
Domain627-701S1 motif
Region698-727Disordered
Compositional bias703-727Polar residues

Sequence similarities

Belongs to the polyribonucleotide nucleotidyltransferase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    727
  • Mass (Da)
    79,389
  • Last updated
    2006-04-18 v1
  • Checksum
    BBD9507C1B301C7F
MTQEVLERSIQVGGRTMTFQTGKIGKQAGGAIFCRYGDTVVSAFATGSAQPREGIDFFPLTVEFEERLYAAGKIPGGFIKREGRPSEKAILSARLIDRPIRPLFPEGYRNDVQVVAQVMSVDQDCASDITGINAASAALTISNVPFEGPVAAVTVGLIGDEFIINPTVEQSEKSVMHLTVAGTKDAVMMVEAGAQEVPEAQMLEAIMFGHREIQRIAEFIENYRLEALERNLAKPKQEVVMKQMPEEIVQAVKAFAYDKMDQAVRTEEKKAREEAIRQVKEEALAHFAEQYPEDSKTIDKILEDFVHKIVRRLITVEHIRPDGRALDEIRPISVEVGILPRTHGTGLFTRGQTQVLTVATLGAVGDEQILDGLGLEESKRYMHHYNFPPYSVGETRPMRGPGRREIGHGALAERALLPVIPDENDFPYTIRLVSEVLESNGSSSMASVCGSTLSLMDAGVPVKSPVAGIAMGLISEENHIAILSDIQGMEDHDGDMDFKVAGTSQGVTALQMDIKIKGVSREILERALTQAKEGRLFILDKMLSVIEKPRPELSPFAPRIITASIHPDKIREVIGPGGKTIKKIIDETGVKIDIEDDGRVFISAVDGEAGENALKIIQALTQEVEVGRIYNGRVTRIMDFGAFVEVIPGVLGLSGKEGLVHISQLAHGRVEKVEDVVKLGDDILVKATGIDKQGRLNLSRKEALPNPNPSSNPNPNGITANRNPRNS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias703-727Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP008230
EMBL· GenBank· DDBJ
BAE84298.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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