Q24UA2 · MTAD_DESHY
- Protein5-methylthioadenosine/S-adenosylhomocysteine deaminase
- GenemtaD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids431 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.
Catalytic activity
- H+ + H2O + S-adenosyl-L-homocysteine = NH4+ + S-inosyl-L-homocysteine
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 66 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 68 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 95 | substrate | ||||
Sequence: E | ||||||
Binding site | 147 | substrate | ||||
Sequence: R | ||||||
Binding site | 185 | substrate | ||||
Sequence: H | ||||||
Binding site | 212 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 215 | substrate | ||||
Sequence: E | ||||||
Binding site | 300 | substrate | ||||
Sequence: D | ||||||
Binding site | 300 | Zn2+ (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 5'-methylthioadenosine deaminase activity | |
Molecular Function | metal ion binding | |
Molecular Function | S-adenosylhomocysteine deaminase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name5-methylthioadenosine/S-adenosylhomocysteine deaminase
- EC number
- Short namesMTA/SAH deaminase
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Clostridia > Eubacteriales > Desulfitobacteriaceae > Desulfitobacterium
Accessions
- Primary accessionQ24UA2
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000312453 | 1-431 | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | |||
Sequence: MSKILIRAMVLPMTGPEDFYPEGEIGIENDRILFVGEKGSAPDSFIPDQIIDLPEDVVMPGLINTHTHAAMTMLRSYADDLPLMPWLQTKIWPFEDKMSDEDIYWGTLLALGEMIQSGTTTMLDMYASMDQVAKAVLEAGTRGVLSRGLIGNAPNGERAFAENIDLVKNYHGAGQGRIQVMFGPHAPYTCSGEFLQRVKQEADRLGVGIHIHVAETEDEIKTIKEQYGKTPVQWLEELGLFGGHVVAAHCVHLTEEDQEIMAQNKVFIAHNPESNMKLNSGTAPIPELRSRGVVVGLGTDGTSSNNNLDMFGEMRSAAFQQKLVKGATALPAYEVLQMATVDGARTLGLHDVGVLAPGYKADLISINFDQPHFYPRFSIPAHLVYVAHAGDVRTVMVDGKILMQERQLMTIDIKRVCREVEKRAKGIAQGL |
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length431
- Mass (Da)47,440
- Last updated2006-04-18 v1
- Checksum7A47A918397BE0C6
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP008230 EMBL· GenBank· DDBJ | BAE84390.1 EMBL· GenBank· DDBJ | Genomic DNA |