Q24742 · TRX_DROVI

Function

function

Histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Functions in segment determination through interaction with genes of bithorax (BX-C) and antennapedia (ANT-C) complexes. Acts as an activator of BX-C. Involved in the very early regulation of homeotic genes expressed only in the posterior region of the embryo.

Catalytic activity

Features

Showing features for dna binding, binding site.

138285001,0001,5002,0002,5003,0003,500
TypeIDPosition(s)Description
DNA binding725-839Nuclear receptor
Binding site3700S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site3702S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site3744S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site3767-3768S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site3770Zn2+ (UniProtKB | ChEBI)
Binding site3816Zn2+ (UniProtKB | ChEBI)
Binding site3818Zn2+ (UniProtKB | ChEBI)
Binding site3823Zn2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthistone acetyltransferase complex
Cellular ComponentMLL1/2 complex
Cellular Componentpolytene chromosome band
Cellular Componenttranscription elongation factor complex
Molecular Functionchromatin binding
Molecular FunctionDNA-binding transcription factor activity
Molecular Functionhistone H3K4 methyltransferase activity
Molecular Functionhistone H3K9 trimethyltransferase activity
Molecular Functionprotein homodimerization activity
Molecular Functionprotein phosphatase 1 binding
Molecular Functionprotein-cysteine methyltransferase activity
Molecular Functionsequence-specific DNA binding
Molecular Functionzinc ion binding
Biological Processeye development
Biological Processgerm cell migration
Biological Processhaltere development
Biological Processheart development
Biological Processmethylation
Biological Processpositive regulation of transcription elongation by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone-lysine N-methyltransferase trithorax
  • EC number

Gene names

    • Name
      trx

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila

Accessions

  • Primary accession
    Q24742

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001248751-3828Histone-lysine N-methyltransferase trithorax

Interaction

Subunit

Interacts with ash1 via its SET domain.

Structure

3D structure databases

Family & Domains

Features

Showing features for region, compositional bias, zinc finger, domain.

TypeIDPosition(s)Description
Region25-179Disordered
Compositional bias40-61Polar residues
Compositional bias69-87Polar residues
Compositional bias97-122Polar residues
Region356-390Disordered
Compositional bias358-390Polar residues
Region512-589Disordered
Compositional bias528-553Acidic residues
Compositional bias561-585Basic and acidic residues
Region933-1036Disordered
Compositional bias957-978Basic and acidic residues
Compositional bias980-1033Polar residues
Region1075-1094Disordered
Region1131-1170Disordered
Compositional bias1137-1170Polar residues
Zinc finger1251-1334PHD-type 1
Zinc finger1335-1380PHD-type 2
Zinc finger1408-1469PHD-type 3
Zinc finger1708-1748C2HC pre-PHD-type
Zinc finger1769-1816PHD-type 4
Domain1856-1913FYR N-terminal
Region2252-2272Disordered
Region2464-2510Disordered
Compositional bias2480-2510Polar residues
Region2826-2848Disordered
Compositional bias2897-2930Polar residues
Region2897-2973Disordered
Compositional bias2956-2973Polar residues
Region2988-3031Disordered
Compositional bias3117-3164Polar residues
Region3117-3178Disordered
Region3314-3338Disordered
Region3457-3487Disordered
Domain3493-3577FYR C-terminal
Domain3690-3806SET
Domain3812-3828Post-SET

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    3,828
  • Mass (Da)
    413,724
  • Last updated
    1996-11-01 v1
  • Checksum
    32059CF303A3C504
MGRSKFPGNPSKSINRKRISVLQLEDEAASAAAAAAAATAATTEQHQQSEQSAGSSASREKGNNCDNDDDDNAPSGAATSGNRGASSGASDAAPEGGNSYGNGSSTGSKTTNGGNVNGGSHHKSATAPAELKECKNQGNQIEPNNCIAAEPDGTEDTNNDDDDDSSNDKKPTAAAAAAAAAAFVPGPSALQRARKGGNKKFKNLNLARPEVMLPSTSKLKQQQQQQLQLNCPSASASSLSSSAAAAAAAAAPTTTTTTASASATLTATATSTSTSSLPGTPLSVIAGGGGGAAAAALLLANPFASVETKVVEVNAAATAAATAAATAAAGAGEDVGMLKASIEMANEAGLEAPAVAVKSSGSSPNPNHNPNAVAGSTSAAAPGAPTATKQKKTVTFKNILETSDDKSVVKRFYNPDNRVPLVSIMKKDSLNRPLNYCRGSEFIVRPSILSKILNKNSNIDKLNSLKFRSVHASSNSIQESSSSTTNLFGSGLSRAFGAPIDDEDAVSGGVTFRKQEPQHKTPEDNDDDGSASSDAIEDDEDIDDDDAEENEEAASEKSAETTASVDEKEADDRQLVMDKHFVLPKRSTRSSRIIKPNKRLLEVGGICSKRSPSDANGKPKPKNYFGLATLPAKCTPRRRRSAATALSQKLGKETFASFATAKVNSSFVLRQPRLQFQTDKSRSFVSAKPTLPTTTVLPASSSAITSANVLSFGALNNANSAVAAASTCAVCSAPVNNKDAPLARKYGVIACEVCRKFNSRMTKISKLSTPMHSNPSTSTAQSGQQLKCTDGGNCSILSLKSQLKNFKKLYKERCKACWLKKCLATLQLPAGHRSRLSAILPASMREEVAPKDDKCPELLSPTASLRFTAPTSSASSGTTIKWKSSAETAVNSIKSNPLAENNVTFGGTPLLRPAILEKPLFLKIGSDNKKAKESKEALGLSPVPSTSEAAVAPGKTTRKAKQDKEKARELEAEKPLSPNAKKTTEANTPETQKDEQPASTTTTVSAASSSTSHTSSAATNSSQLETTEAANASAVPDNLKRQRIDLKGPRVKHVCRSASIVLGQPLATFGDEEEELAAAEAGPAPTTTTTTTSPEVIIKKPKSPQPMQMIIDENDNCASCILTPTEATAEAQPAVKSVLESRSSKSNTQTEAKKTPATSGSSKGKVTTRNATATVTSVASSLVATKKQRNIEVSSSISSSQAAATQSRRALAKEVNRLKALISIDFWENYDPAEVCQTGFGLIVTETVAQRALCFLCGSTGLDPLIFCACCCEPYHQYCVLDEYNLKHSSFEDTLMTSLLETSNNACAISAATNTALNQLTQRLNWLCPRCTVCYTCNMSSGSKVKCQKCQKNYHSTCLGTSKRLLGADRPLICVNCLKCKSCATTKVSKFVGNLPMCTACFKLRKKGNFCPICQKCYDDNDFDLKMMECGDCNQWVHSKCEGLSDEQYNLLSTLPESIEFICKKCARRCDVSRNKADEWRQAVMEEFKSSLYSVLKLLSKSRQACALLKLSPRKNWRCCSAGAQPAKAHSQGKLQPKALQFTYNGLGSDGESQNSDDIYEFKEQHSTNRKPSTPVPCSCLQPLSQSPSFSLVDIKQKIASNAYVSLAEFNYDMSQVIQQSNCDELDIAYKELLSEQFPWFQNETKACTDALEEDMFESCGYEELKESPTTYAEHHTASQAPRTGLLDIPLDDVDDLGGCAVKTRLDTRVCLFCRKSGEGLSGEEARLLYCGHDCWVHINCAMWSAEVFEEIDGSLQNVHSAVARGRMIKCTVCGNRGATVGCNVKSCGEHYHYPCARTIDCAFLTDKSMYCPAHARNALKANGSPSVTYESNFEVSRPVYVELERKRKKLIVPAKVQFHIGSVAVRQLGSIVPRFSDSFEAIVPINFLCSRLYWSSKEPWKIVEYTVRTTIQNSYSSTLTLDAGRNFTVDHTNPNCSLVQLGLAQIARWHSSLARSDLLDTDWAEFPNSYVPADENTEEEPQQNADLLPPEIKDAIFEDLPHELLDGISMLDIFMYEDLGDKTELFAMSEQSKDGTTATSQAGGASVIICDEDTRNSNSLNKHLVLSNCCTASNPVDDAMLCAARSSSQEKECGDVLKKTDTAPTRSWPKLDGGSVAAFKRRKLSKNIAEGVLLSLNQRSKKEMATVAGITRRQSVCGSSELPAEGSATMRTKSFTWSAAKCLFEKNESREEPAKLTIMQMDGVDDSITEYRIIGSDGNLSTAQFTGQVKCERCQCTYRNYDSFQRHLGSCEPMSTSESESETATGTAQLSAESLNELQKQALAAATLSNTGGLNYLQTSFPQVQNLATLGQFGVQGLQGLQTLQLQPQSLGNGFFLSQPNAAQATSNGNDVLQLYANSLQNLAANLGGGFTLTQPTMSTQAQPQLIALSTNPDGTQQFIQLPQSNGATTQLLQTAAPLRCNATYQTLQATNSDKKIVLLFLEAGDPLQEVVTQAAQQATAAAHQKQLKSGHGVKPIQAKLQGQQQQQRHQQHQQHQQHQQQQQQQQQQQQQQQTPITVAQHGGTTQLLGQNLLQPQLLFQSNAQPQTQQLLLPQTQAQNIISFVTGDGSQNQPLQYISIPTTNDFKPQQTTSTPTFLTAPGGGATFLQTDASGNLMLTTAPANSGLQMLTGQLQTQPQVIGTLIQPQTLQLTTGADGTQTATAQQPLILGGATGGGTTGLEFATAPQVILATQPMYYGLETIVQNTVMSSQQFVSTAMPGVLSQNSSFSATTTQVFQASKIEPIVDLPAGYVVLNNAVDASGNTSWLQQSQTQATDDATAQLLQNAGFQFQTTPTTSTQQTMSTDYAPPLVVTAKVPPVAQMKRNTNANKSPISVLSKVQPQPQQSQVVNKVLPTNVIQQQQQQQQQQQQQQQQMQPKQQLAGNANLKLTSQFQRQQQANELKNKQAAGQQTGSTCGAPPSIASKPLQKKTNLIRPIHKVEVKPKIMKQAPKLATSAASMQHHQQQQSPAAINQVAKVALLQQRLAPAPQPQQQEPQEEQQHLHQQQQQQQQQQQHMQQHQQQQQQLSMPQLLRAQQPIISIVNTAEPQAATQFVIRPALQAQAQPIQLQEQQSQQQQQQPAEQLINGKAARLQRYASNSLPTNVVNPLQQQRCASANNSSNSNVTQQNSTITINSRPTNRVLPMQQRQEPTPLSNDVVVQSPTPPKPIEEPVPAGASTQKPIVKCYAQLEQKSPGYETELKTNITLDNLEQTNSITTMQLQQPQQGPIYGEQIFEKQSEAQVQLEKPKHNDLMLLEATSCQQQQQQQQHMEMVVDNGFQLTSNESCLLEKHGFNVEAVPMDTEDHYASMKNGSGGGAAEGIGQVDDAEEDEDDDDDFSLKMATSACNDHEMSDSEEPAVKEKISKILDNLTNDDCSDSIATATTVEASAGYQQMVEDVLATTAAGSVSTDDETFTATAEAVEAAASYINEMAEAHELQLKQLQAGVELDLKKPKLDVPQQQPDTVPPNVVPTAAAPQQPPPMRDPKKISGPHLLYEIQSEDGFTYKSSSIAEIWEKVFEAVQVARRAHGLTPLPEGPLADMSGVQMIGLKTNALKYLIEQLPGVEKCVKYTPKYHKRNGNVSTAAGGGHARTAGSNPAALAAGAESLIDYGSDQEELQENAYECARCEPYVSRSEYDMFSWLASRHRKQPIQVFVQPSDNELVPRRGTGSNLPMAMKYRTLKETYKDYVGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLTDKRERYYDSRGIGCYMFKIDDNLVVDATMRGNAARFINHSCEPNCYSKVVDILGHKHIIIFALRRIVQGEELTYDYKFPFEDEKIPCSCGSKRCRKYLN

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias40-61Polar residues
Compositional bias69-87Polar residues
Compositional bias97-122Polar residues
Compositional bias358-390Polar residues
Compositional bias528-553Acidic residues
Compositional bias561-585Basic and acidic residues
Compositional bias957-978Basic and acidic residues
Compositional bias980-1033Polar residues
Compositional bias1137-1170Polar residues
Compositional bias2480-2510Polar residues
Compositional bias2897-2930Polar residues
Compositional bias2956-2973Polar residues
Compositional bias3117-3164Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Z50038
EMBL· GenBank· DDBJ
CAA90349.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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