Q24708 · CSW_DROVI
- ProteinTyrosine-protein phosphatase corkscrew
- Genecsw
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids764 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Required in all receptor tyrosine kinase signaling pathways. Functions downstream of the receptor tyrosine kinase torso, acting in concert with D-Raf via tailless. Also functions downstream of Egfr (epidermal growth factor receptor) and btl (fibroblast growth factor receptor). The SH2 domain suggests that csw effects its role by mediating heteromeric protein interactions. Maternally required for normal determination of cell fates at the termini of the embryo. Required for cell fate specification of the ventral ectoderm, in the developing embryonic CNS and for embryonic tracheal cell migration. Functions during imaginal development for proper formation of adult structures such as eyes, aristae, L5 wing vein and the tarsal claw (By similarity).
Catalytic activity
- H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 422 | substrate | ||||
Sequence: D | ||||||
Active site | 460 | Phosphocysteine intermediate | ||||
Sequence: C | ||||||
Binding site | 460-466 | substrate | ||||
Sequence: CSAGIGR | ||||||
Binding site | 507 | substrate | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | protein tyrosine phosphatase activity | |
Biological Process | anatomical structure morphogenesis | |
Biological Process | neuron development | |
Biological Process | terminal region determination | |
Biological Process | torso signaling pathway |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine-protein phosphatase corkscrew
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila
Accessions
- Primary accessionQ24708
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000094852 | 1-764 | Tyrosine-protein phosphatase corkscrew | |||
Sequence: WFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDFVLSVRTDDKVTHVMIRWQDKKYDVGGGESFATLSELIEHYKRHPMVETCGTVVHLRQPFNATRITAAGINARVEQLVKGGFWEEFESLQQDSRDTFSRHEGYKDENRLKNRYHDHTRVKLQDVERSAPGAEYINANYIRLPTDGDLYNMSSSSESLNSTVAACPACTAAQTQRNCPNCHLLNKTCVKCAVKSATLPTNCATCNRKSDSLSKHKRSESMSASANASAAGTGPGTPTAAGNTSAAAALNGCLAVLLKKHCGDASPPPSTTSSCSGPLTGSLLNGEGNQFKTYIATQGCLANTKTDFWNMIWQENTRVIVMTTKEIERGKTKCERYWPDEGQCKQFGHAKVHCIKENSTNDYTLREFLFSWRDKPERRIYHYHFQVWPDHGVPADPGCVLNFLQDVNTKQSSLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGMVQTEAQYKFVYYAVQHYIQTLIARKRAEEQSLQVGREYTNIKYTGEIGNDSQRSPLPPAISNLSLVSCKSAVAEPLTAAAAAAAVAANAGNKHAAKLQPPLPPLGASNNNNSSGNSGSYCNSSSSTSTAQHNGVVSSSNNCSSGSGSANSSNANGNGNILGNGSNMRKSNFYSDSLAALKLQQQQLHDAATAAAAAALASAAAPAATTTAASASAAAAAAAAAKYKNIPKDMNSLRQPHAAYVAAAPALPPPPTPPRKT |
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-95 | SH2 | ||||
Sequence: WFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDFVLSVRTDDKVTHVMIRWQDKKYDVGGGESFATLSELIEHYKRHPMVETCGTVVHLRQPF | ||||||
Domain | 117-522 | Tyrosine-protein phosphatase | ||||
Sequence: FWEEFESLQQDSRDTFSRHEGYKDENRLKNRYHDHTRVKLQDVERSAPGAEYINANYIRLPTDGDLYNMSSSSESLNSTVAACPACTAAQTQRNCPNCHLLNKTCVKCAVKSATLPTNCATCNRKSDSLSKHKRSESMSASANASAAGTGPGTPTAAGNTSAAAALNGCLAVLLKKHCGDASPPPSTTSSCSGPLTGSLLNGEGNQFKTYIATQGCLANTKTDFWNMIWQENTRVIVMTTKEIERGKTKCERYWPDEGQCKQFGHAKVHCIKENSTNDYTLREFLFSWRDKPERRIYHYHFQVWPDHGVPADPGCVLNFLQDVNTKQSSLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGMVQTEAQYKFVYYAVQHY | ||||||
Region | 174-325 | PTPase insert (Cys/Ser-rich) | ||||
Sequence: IRLPTDGDLYNMSSSSESLNSTVAACPACTAAQTQRNCPNCHLLNKTCVKCAVKSATLPTNCATCNRKSDSLSKHKRSESMSASANASAAGTGPGTPTAAGNTSAAAALNGCLAVLLKKHCGDASPPPSTTSSCSGPLTGSLLNGEGNQFKT | ||||||
Region | 246-273 | Disordered | ||||
Sequence: SKHKRSESMSASANASAAGTGPGTPTAA | ||||||
Compositional bias | 251-273 | Polar residues | ||||
Sequence: SESMSASANASAAGTGPGTPTAA | ||||||
Region | 599-666 | Disordered | ||||
Sequence: AAKLQPPLPPLGASNNNNSSGNSGSYCNSSSSTSTAQHNGVVSSSNNCSSGSGSANSSNANGNGNILG | ||||||
Compositional bias | 608-666 | Polar residues | ||||
Sequence: PLGASNNNNSSGNSGSYCNSSSSTSTAQHNGVVSSSNNCSSGSGSANSSNANGNGNILG |
Sequence similarities
Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length764
- Mass (Da)82,126
- Last updated1996-11-01 v1
- Checksum66008EA8560A2F7D
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: W | ||||||
Compositional bias | 251-273 | Polar residues | ||||
Sequence: SESMSASANASAAGTGPGTPTAA | ||||||
Compositional bias | 608-666 | Polar residues | ||||
Sequence: PLGASNNNNSSGNSGSYCNSSSSTSTAQHNGVVSSSNNCSSGSGSANSSNANGNGNILG |