Q24570 · GRIM_DROME

Function

function

Activator of apoptosis, independent of rpr and hid, that acts on the effector Dredd.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentmitochondrion
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular Functionprotein homodimerization activity
Biological Processapoptotic process
Biological Processapoptotic signaling pathway
Biological Processdetermination of adult lifespan
Biological Processlarval central nervous system remodeling
Biological Processmelanization defense response
Biological Processneuron apoptotic process
Biological Processpositive regulation of apoptotic process
Biological Processprogrammed cell death
Biological Processprogrammed cell death involved in cell development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cell death protein Grim

Gene names

    • Name
      grim
    • ORF names
      CG4345

Organism names

  • Taxonomic identifier
  • Strains
    • Canton-S
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q24570
  • Secondary accessions
    • Q9VVP6

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000838481-138Cell death protein Grim

Proteomic databases

Expression

Developmental stage

Expression coincides with the onset of programmed cell death (PCD) at all stages of embryonic development.

Gene expression databases

Interaction

Subunit

Interacts with Diap2 (via BIR2 domain).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q24570Diap2 Q243072EBI-167445, EBI-112046

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region21-71Disordered
Region119-138Disordered

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    138
  • Mass (Da)
    15,486
  • Last updated
    2001-06-01 v2
  • Checksum
    DE3FAC0487F0DB4E
MAIAYFIPDQAQLLARSYQQNGQQTAASPRTTATAAAPSQQQQQSQQQQQQQRHHHQQQRPQFRANISVPLGSQQGSMTMSEFGCWDLLAQIFCYALRIYSYSSSQRQPTVIQISFEISSGGQNNDEDDVTDATSKEN

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict93in Ref. 1; AAC47727

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U61976
EMBL· GenBank· DDBJ
AAC47727.1
EMBL· GenBank· DDBJ
mRNA
AE014296
EMBL· GenBank· DDBJ
AAF49265.1
EMBL· GenBank· DDBJ
Genomic DNA
BT003512
EMBL· GenBank· DDBJ
AAO39516.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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