Q24324 · DSOR1_DROME
- ProteinDual specificity mitogen-activated protein kinase kinase dSOR1
- GeneDsor1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids396 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Required downstream of Raf in the sevenless (sev), torso (tor), and Drosophila EGF receptor homolog (DER) signal transduction pathways. Involved in both positive regulation (at the posterior terminus) and negative regulation (at the anterior domain) of tll, as in other terminal class gene products, maybe via the ERK-A kinase.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site, active site.
GO annotations
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDual specificity mitogen-activated protein kinase kinase dSOR1
- EC number
- Short namesDownstream of RAF; MAPKK
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ24324
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | 394 | in strain: Reids2 | ||||
Sequence: S → L |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000085928 | 1-396 | Dual specificity mitogen-activated protein kinase kinase dSOR1 | |||
Sequence: MSKNKLNLVLPPVNTEATVAAATVAPTPPFKTPSGTDTHSLLGKPKTSIDALTETLEGLDMGDTERKRIKMFLSQKEKIGELSDEDLEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLHECNFPHIVGFYGAFYSDGEISICMEYMDGGSLDLILKRAGRIPESILGRITLAVLKGLSYLRDNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPNTATLESIFADNAEESGQPTDEPRAMAIFELLDYIVNEPPPKLEHKIFSTEFKDFVDICLKKQPDERADLKTLLSHPWIRKAELEEVDISGWVCKTMDLPPSTPKRNTSPN | ||||||
Modified residue | 237 | Phosphoserine; by RAF | ||||
Sequence: S | ||||||
Modified residue | 241 | Phosphoserine; by RAF | ||||
Sequence: S |
Post-translational modification
Phosphorylation on Ser/Thr by MAP kinase kinase kinases regulates positively the kinase activity.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Developmental stage
Expressed both maternally and zygotically.
Gene expression databases
Interaction
Subunit
Interacts with Raf and ksr; Dsor1 binding to ksr probably promotes ksr and Raf dimerization and ksr-mediated Raf transactivation.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q24324 | Raf P11346 | 4 | EBI-671282, EBI-664624 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 25-44 | Disordered | ||||
Sequence: APTPPFKTPSGTDTHSLLGK | ||||||
Compositional bias | 29-43 | Polar residues | ||||
Sequence: PFKTPSGTDTHSLLG | ||||||
Domain | 87-364 | Protein kinase | ||||
Sequence: LEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLHECNFPHIVGFYGAFYSDGEISICMEYMDGGSLDLILKRAGRIPESILGRITLAVLKGLSYLRDNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPNTATLESIFADNAEESGQPTDEPRAMAIFELLDYIVNEPPPKLEHKIFSTEFKDFVDICLKKQPDERADLKTLLSHPWI |
Sequence similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length396
- Mass (Da)43,870
- Last updated2005-08-16 v2
- Checksum9245CED1DA750C33
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
X2JAZ3 | X2JAZ3_DROME | Dsor1 | 393 |
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 29-43 | Polar residues | ||||
Sequence: PFKTPSGTDTHSLLG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D13782 EMBL· GenBank· DDBJ | BAA02925.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AY135075 EMBL· GenBank· DDBJ | AAN17587.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY135076 EMBL· GenBank· DDBJ | AAN17588.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY135077 EMBL· GenBank· DDBJ | AAN17589.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY135078 EMBL· GenBank· DDBJ | AAN17590.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY135079 EMBL· GenBank· DDBJ | AAN17591.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY135080 EMBL· GenBank· DDBJ | AAN17592.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY135081 EMBL· GenBank· DDBJ | AAN17593.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY135082 EMBL· GenBank· DDBJ | AAN17594.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY135083 EMBL· GenBank· DDBJ | AAN17595.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY135084 EMBL· GenBank· DDBJ | AAN17596.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY135085 EMBL· GenBank· DDBJ | AAN17597.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY135086 EMBL· GenBank· DDBJ | AAN17598.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY135087 EMBL· GenBank· DDBJ | AAN17599.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY135088 EMBL· GenBank· DDBJ | AAN17600.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY135089 EMBL· GenBank· DDBJ | AAN17601.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY135090 EMBL· GenBank· DDBJ | AAN17602.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY135091 EMBL· GenBank· DDBJ | AAN17603.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY135092 EMBL· GenBank· DDBJ | AAN17604.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY135093 EMBL· GenBank· DDBJ | AAN17605.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014298 EMBL· GenBank· DDBJ | AAF46475.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY058692 EMBL· GenBank· DDBJ | AAL13921.1 EMBL· GenBank· DDBJ | mRNA |