Q24174 · ABRU_DROME
- ProteinProtein abrupt
- Geneab
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids904 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Expression is vital for development; may be involved in transcriptional regulation. In embryos, muscle specific expression is required for segmental nerve b (SNb) motoneuron target recognition within ventral longitudinal muscles. Has a role in establishing and maintaining embryonic muscle attachments, adult sensory cell formation (macrochaetae) and morphogenesis of adult appendages (legs, antenna aristae and male external genitalia). Has a role in the morphogenesis of the class I dendritic neurons: selective expression of ab in class I da neurons plays a pivotal role in forming dendritic arbors, which are characteristic of the class I cells. The development of more complex arbors of class II-IV neurons depends on the absence of ab.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | metal ion binding | |
Biological Process | axon choice point recognition | |
Biological Process | border follicle cell migration | |
Biological Process | dendrite morphogenesis | |
Biological Process | muscle attachment | |
Biological Process | mushroom body development | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | regulation of DNA-templated transcription | |
Biological Process | regulation of transcription by RNA polymerase II | |
Biological Process | sensory organ development | |
Biological Process | synaptic target recognition | |
Biological Process | wing disc development |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein abrupt
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ24174
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Flies exhibit disrupts to motoneuron guidance and connectivity. Loss of ab in class I neurons results in malformation of their typical comb-like arbor patterns and generation of supernumerary branch terminals.
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 585 | In allele AB-CLU2; lethal. | ||||
Sequence: R → C |
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000046907 | 1-904 | Protein abrupt | |||
Sequence: MTESTQLQTAENNNAGVVKMEPPPPATSSVSVSAAAAAHALSSLSSLTMAATGSALSPATPPPSLNLSHQQQQHQQHYALKWNDFQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCEHPIVILRDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKTAHLLQIRGLADVNGGYPYSKALSAALSHNSSNNNNNNSSSNNSLSNNNNNNNNNAESSNHNKISSYLSPNQTSAACNNSSNSNSNNHSSSHNNSSSNNISGSLNSSLNSPFSAPQIPPPVTASSAAAAAAAAASLTAAVAAAAAATAASAGSSSSAASGQTSGTPAIQELKASSAASPVRNPNPNPSKASSSNHWDMGEMEGSRKSHLTPPPQKRIKSADLFRAQHGISPERLLLDREFPVAGQHPLTRNRSGRDTSKDRERNLELRESLLGQALENSNGQQANPKHELGQSAGEDSNSSDTEPSDRGDGQHDGTLDGIDNQRSHSFPNAFLGLQGIPGLLPGPSGINSDFVSRRSLEMRVRATDPRPCPKCGKIYRSAHTLRTHLEDKHTVCPGYRCVLCGTVAKSRNSLHSHMSRQHRGISTKDLPVLPMPSAFDPELASRLLAKAGVKISPAELRARASPTGGSGSSGGGGGGGSSQAKLDLSNASGGPMDDAEDSDDDPEDLTTGNGLYGMGGSSSDLSRYHESLLSNFGHARMRNEAAAVAATAAALGQPKDLGVQLPNSNAPGQSLLDTYLQFITENTFGMGMSQEQAAAAALRAKMAQLNAMGHSLDNLPPGLLPGQFDLSKLAAGNPAFGQSGPGLTIEPIMRHEQAAGNLSPNRPLALNSGGRMMGHDEMAENDGDMRREGSEPMDLGLDNNQSGSNHEVANSDAEENYSEDEGVHNT | ||||||
Modified residue | 474 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 837 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 846 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 868 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 889 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 896 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in CNS midline cells during embryonic stages 9-13. Expression also seen in cells of the stomagastric nervous system. Segmentally repeated stripes of ectodermal expression appear at stage 11 that become uniform by stage 12 and throughout embryogenesis. Expressed at variable levels in somatic muscles from stage 16 and in all imaginal disks during larval development. Expression is seen in da neurons that grow in two-dimensional dendrites underneath the epidermis during late embryonic, larval, and pupal stages.
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-15 | Polar residues | ||||
Sequence: MTESTQLQTAENNNA | ||||||
Region | 1-30 | Disordered | ||||
Sequence: MTESTQLQTAENNNAGVVKMEPPPPATSSV | ||||||
Region | 53-72 | Disordered | ||||
Sequence: GSALSPATPPPSLNLSHQQQ | ||||||
Domain | 103-168 | BTB | ||||
Sequence: VDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCEHPIVILRDVRCDDVENLLSFMYNGEVNVSH | ||||||
Region | 204-287 | Disordered | ||||
Sequence: SHNSSNNNNNNSSSNNSLSNNNNNNNNNAESSNHNKISSYLSPNQTSAACNNSSNSNSNNHSSSHNNSSSNNISGSLNSSLNSP | ||||||
Compositional bias | 349-374 | Polar residues | ||||
Sequence: ASSAASPVRNPNPNPSKASSSNHWDM | ||||||
Region | 349-390 | Disordered | ||||
Sequence: ASSAASPVRNPNPNPSKASSSNHWDMGEMEGSRKSHLTPPPQ | ||||||
Region | 411-438 | Disordered | ||||
Sequence: LLDREFPVAGQHPLTRNRSGRDTSKDRE | ||||||
Compositional bias | 451-476 | Polar residues | ||||
Sequence: ALENSNGQQANPKHELGQSAGEDSNS | ||||||
Region | 451-501 | Disordered | ||||
Sequence: ALENSNGQQANPKHELGQSAGEDSNSSDTEPSDRGDGQHDGTLDGIDNQRS | ||||||
Compositional bias | 477-496 | Basic and acidic residues | ||||
Sequence: SDTEPSDRGDGQHDGTLDGI | ||||||
Zinc finger | 544-567 | C2H2-type 1 | ||||
Sequence: RPCPKCGKIYRSAHTLRTHLEDKH | ||||||
Zinc finger | 573-596 | C2H2-type 2 | ||||
Sequence: YRCVLCGTVAKSRNSLHSHMSRQH | ||||||
Region | 633-696 | Disordered | ||||
Sequence: ELRARASPTGGSGSSGGGGGGGSSQAKLDLSNASGGPMDDAEDSDDDPEDLTTGNGLYGMGGSS | ||||||
Compositional bias | 640-663 | Polar residues | ||||
Sequence: PTGGSGSSGGGGGGGSSQAKLDLS | ||||||
Region | 832-904 | Disordered | ||||
Sequence: AAGNLSPNRPLALNSGGRMMGHDEMAENDGDMRREGSEPMDLGLDNNQSGSNHEVANSDAEENYSEDEGVHNT | ||||||
Compositional bias | 853-871 | Basic and acidic residues | ||||
Sequence: HDEMAENDGDMRREGSEPM | ||||||
Compositional bias | 873-889 | Polar residues | ||||
Sequence: LGLDNNQSGSNHEVANS |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q24174-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameA
- SynonymsLong
- Length904
- Mass (Da)95,093
- Last updated2001-10-01 v2
- Checksum9DF8F4EDDF8E5CF7
Q24174-2
- NameB
- SynonymsShort, D, F
- Differences from canonical
- 356-365: Missing
Q24174-3
- NameC
- Differences from canonical
- 1-535: Missing
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
M9PB99 | M9PB99_DROME | ab | 899 |
Features
Showing features for compositional bias, alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-15 | Polar residues | ||||
Sequence: MTESTQLQTAENNNA | ||||||
Alternative sequence | VSP_047504 | 1-535 | in isoform C | |||
Sequence: Missing | ||||||
Sequence conflict | 264 | in Ref. 4; AAN71338 | ||||
Sequence: H → P | ||||||
Compositional bias | 349-374 | Polar residues | ||||
Sequence: ASSAASPVRNPNPNPSKASSSNHWDM | ||||||
Alternative sequence | VSP_006823 | 356-365 | in isoform B | |||
Sequence: Missing | ||||||
Compositional bias | 451-476 | Polar residues | ||||
Sequence: ALENSNGQQANPKHELGQSAGEDSNS | ||||||
Compositional bias | 477-496 | Basic and acidic residues | ||||
Sequence: SDTEPSDRGDGQHDGTLDGI | ||||||
Compositional bias | 640-663 | Polar residues | ||||
Sequence: PTGGSGSSGGGGGGGSSQAKLDLS | ||||||
Sequence conflict | 695 | in Ref. 1; AAA86639 | ||||
Sequence: S → T | ||||||
Compositional bias | 853-871 | Basic and acidic residues | ||||
Sequence: HDEMAENDGDMRREGSEPM | ||||||
Compositional bias | 873-889 | Polar residues | ||||
Sequence: LGLDNNQSGSNHEVANS | ||||||
Sequence conflict | 888 | in Ref. 4; AAN71338 | ||||
Sequence: N → D |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U43733 EMBL· GenBank· DDBJ | AAA86639.1 EMBL· GenBank· DDBJ | mRNA | ||
AE014134 EMBL· GenBank· DDBJ | AAF53087.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014134 EMBL· GenBank· DDBJ | AAN10774.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014134 EMBL· GenBank· DDBJ | ACZ94239.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014134 EMBL· GenBank· DDBJ | AGB92914.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT001583 EMBL· GenBank· DDBJ | AAN71338.1 EMBL· GenBank· DDBJ | mRNA | ||
BT003807 EMBL· GenBank· DDBJ | AAO41490.1 EMBL· GenBank· DDBJ | mRNA |