Q24048 · ATPB2_DROME

Function

function

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxon
Cellular Componentplasma membrane
Cellular Componentseptate junction
Cellular Componentsodium:potassium-exchanging ATPase complex
Molecular FunctionATPase activator activity
Biological Processcell adhesion involved in heart morphogenesis
Biological Processestablishment of glial blood-brain barrier
Biological Processintracellular potassium ion homeostasis
Biological Processintracellular sodium ion homeostasis
Biological Processmonoatomic cation transport
Biological Processopen tracheal system development
Biological Processpotassium ion import across plasma membrane
Biological Processregulation of tube diameter, open tracheal system
Biological Processregulation of tube length, open tracheal system
Biological Processregulation of tube size, open tracheal system
Biological Processsensory perception of sound
Biological Processseptate junction assembly
Biological Processsodium ion export across plasma membrane

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sodium/potassium-transporting ATPase subunit beta-2
  • Alternative names
    • Protein nervana 2
    • Sodium/potassium-dependent ATPase subunit beta-2

Gene names

    • Name
      nrv2
    • ORF names
      CG9261

Organism names

  • Taxonomic identifier
  • Strains
    • Canton-S
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q24048
  • Secondary accessions
    • Q24047
    • Q9VM84
    • Q9VM85

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-50Cytoplasmic
Transmembrane51-71Helical; Signal-anchor for type II membrane protein
Topological domain72-323Extracellular

Keywords

PTM/Processing

Features

Showing features for chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00002191211-323Sodium/potassium-transporting ATPase subunit beta-2
Disulfide bond153↔165
Disulfide bond175↔189
Glycosylation180N-linked (GlcNAc...) asparagine
Glycosylation206N-linked (GlcNAc...) asparagine
Disulfide bond241↔298

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

In embryos, it is expressed in the neurons of the CNS and PNS, in Garland cells and posterior spiracles. In adults, it shows a nervous system specific distribution: optic lobes, brain, thoracic ganglia and axonal pathways in the leg. Both isoforms concentrate in the adult head, isoform 2.2 being predominant. Both isoforms are weakly expressed in the thorax and very poorly expressed in the abdomen.

Developmental stage

Expression in embryos is first seen 12 hours after oviposition, peaks at 24 hours and decreases to a low level by 48 hours. Low levels are seen during larval and early pupal development. Levels increase during late pupae to maximal at the adult stage.

Gene expression databases

Interaction

Subunit

The sodium/potassium-transporting ATPase is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q24048-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    2.2
  • Synonyms
    C, F
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    323
  • Mass (Da)
    37,283
  • Last updated
    2000-12-01 v2
  • Checksum
    8926A9D1FC48D6EF
MPTITEDCIDGFQQYYSRPPERPKKKSLKQMVYDSEDNSYFGRSMDSWAKIGIFYVAFYGVLAALVAICMWAFFQTLDPRIPKWTLDRSLIGTNPGLGFRPLPPVDNVESTLIWYKGTQHENYKHWTDSLDDFLAVYKVPGLTPGRGQNIYNCDYNQPPPKGQVCDVDIKTWSPCTKENNYSYHKSAPCIFLKLNKIYGWIPEYYNRSNDLPANMPASLKTYIAEVEKTQPEKLNTIWVSCEGENPADQENIGAVNYLPIRGFPGYFYPYQNSEGYLSPLVAVHFQRPKRGIIINVECRAWARNIIHDRKERIGSVHYELLID

Q24048-2

  • Name
    2.1
  • Synonyms
    A, D
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-46: MPTITEDCIDGFQQYYSRPPERPKKKSLKQMVYDSEDNSYFGRSMD → MSKPVPMSPSFVDEDLHNLRKPKPFKLGQFLYNTEDGTVMGRDRS

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A4V0B5A4V0B5_DROMEnrv2323
Q1RL12Q1RL12_DROMEnrv2322

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0003501-46in isoform 2.1
Sequence conflict162in Ref. 1; AAC46609/AAC46610
Sequence conflict307in Ref. 1; AAC46609/AAC46610

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U22439
EMBL· GenBank· DDBJ
AAC46609.1
EMBL· GenBank· DDBJ
mRNA
U22440
EMBL· GenBank· DDBJ
AAC46610.1
EMBL· GenBank· DDBJ
mRNA
AE014134
EMBL· GenBank· DDBJ
AAF52438.2
EMBL· GenBank· DDBJ
Genomic DNA
AE014134
EMBL· GenBank· DDBJ
AAN10600.1
EMBL· GenBank· DDBJ
Genomic DNA
AY060289
EMBL· GenBank· DDBJ
AAL25328.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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