Q24048 · ATPB2_DROME
- ProteinSodium/potassium-transporting ATPase subunit beta-2
- Genenrv2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids323 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | plasma membrane | |
Cellular Component | septate junction | |
Cellular Component | sodium:potassium-exchanging ATPase complex | |
Molecular Function | ATPase activator activity | |
Biological Process | cell adhesion involved in heart morphogenesis | |
Biological Process | establishment of glial blood-brain barrier | |
Biological Process | intracellular potassium ion homeostasis | |
Biological Process | intracellular sodium ion homeostasis | |
Biological Process | monoatomic cation transport | |
Biological Process | open tracheal system development | |
Biological Process | potassium ion import across plasma membrane | |
Biological Process | regulation of tube diameter, open tracheal system | |
Biological Process | regulation of tube length, open tracheal system | |
Biological Process | regulation of tube size, open tracheal system | |
Biological Process | sensory perception of sound | |
Biological Process | septate junction assembly | |
Biological Process | sodium ion export across plasma membrane |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSodium/potassium-transporting ATPase subunit beta-2
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ24048
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type II membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-50 | Cytoplasmic | ||||
Sequence: MPTITEDCIDGFQQYYSRPPERPKKKSLKQMVYDSEDNSYFGRSMDSWAK | ||||||
Transmembrane | 51-71 | Helical; Signal-anchor for type II membrane protein | ||||
Sequence: IGIFYVAFYGVLAALVAICMW | ||||||
Topological domain | 72-323 | Extracellular | ||||
Sequence: AFFQTLDPRIPKWTLDRSLIGTNPGLGFRPLPPVDNVESTLIWYKGTQHENYKHWTDSLDDFLAVYKVPGLTPGRGQNIYNCDYNQPPPKGQVCDVDIKTWSPCTKENNYSYHKSAPCIFLKLNKIYGWIPEYYNRSNDLPANMPASLKTYIAEVEKTQPEKLNTIWVSCEGENPADQENIGAVNYLPIRGFPGYFYPYQNSEGYLSPLVAVHFQRPKRGIIINVECRAWARNIIHDRKERIGSVHYELLID |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000219121 | 1-323 | Sodium/potassium-transporting ATPase subunit beta-2 | |||
Sequence: MPTITEDCIDGFQQYYSRPPERPKKKSLKQMVYDSEDNSYFGRSMDSWAKIGIFYVAFYGVLAALVAICMWAFFQTLDPRIPKWTLDRSLIGTNPGLGFRPLPPVDNVESTLIWYKGTQHENYKHWTDSLDDFLAVYKVPGLTPGRGQNIYNCDYNQPPPKGQVCDVDIKTWSPCTKENNYSYHKSAPCIFLKLNKIYGWIPEYYNRSNDLPANMPASLKTYIAEVEKTQPEKLNTIWVSCEGENPADQENIGAVNYLPIRGFPGYFYPYQNSEGYLSPLVAVHFQRPKRGIIINVECRAWARNIIHDRKERIGSVHYELLID | ||||||
Disulfide bond | 153↔165 | |||||
Sequence: CDYNQPPPKGQVC | ||||||
Disulfide bond | 175↔189 | |||||
Sequence: CTKENNYSYHKSAPC | ||||||
Glycosylation | 180 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 206 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 241↔298 | |||||
Sequence: CEGENPADQENIGAVNYLPIRGFPGYFYPYQNSEGYLSPLVAVHFQRPKRGIIINVEC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
In embryos, it is expressed in the neurons of the CNS and PNS, in Garland cells and posterior spiracles. In adults, it shows a nervous system specific distribution: optic lobes, brain, thoracic ganglia and axonal pathways in the leg. Both isoforms concentrate in the adult head, isoform 2.2 being predominant. Both isoforms are weakly expressed in the thorax and very poorly expressed in the abdomen.
Developmental stage
Expression in embryos is first seen 12 hours after oviposition, peaks at 24 hours and decreases to a low level by 48 hours. Low levels are seen during larval and early pupal development. Levels increase during late pupae to maximal at the adult stage.
Gene expression databases
Structure
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q24048-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name2.2
- SynonymsC, F
- Length323
- Mass (Da)37,283
- Last updated2000-12-01 v2
- Checksum8926A9D1FC48D6EF
Q24048-2
- Name2.1
- SynonymsA, D
- Differences from canonical
- 1-46: MPTITEDCIDGFQQYYSRPPERPKKKSLKQMVYDSEDNSYFGRSMD → MSKPVPMSPSFVDEDLHNLRKPKPFKLGQFLYNTEDGTVMGRDRS
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_000350 | 1-46 | in isoform 2.1 | |||
Sequence: MPTITEDCIDGFQQYYSRPPERPKKKSLKQMVYDSEDNSYFGRSMD → MSKPVPMSPSFVDEDLHNLRKPKPFKLGQFLYNTEDGTVMGRDRS | ||||||
Sequence conflict | 162 | in Ref. 1; AAC46609/AAC46610 | ||||
Sequence: G → A | ||||||
Sequence conflict | 307 | in Ref. 1; AAC46609/AAC46610 | ||||
Sequence: H → R |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U22439 EMBL· GenBank· DDBJ | AAC46609.1 EMBL· GenBank· DDBJ | mRNA | ||
U22440 EMBL· GenBank· DDBJ | AAC46610.1 EMBL· GenBank· DDBJ | mRNA | ||
AE014134 EMBL· GenBank· DDBJ | AAF52438.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014134 EMBL· GenBank· DDBJ | AAN10600.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY060289 EMBL· GenBank· DDBJ | AAL25328.1 EMBL· GenBank· DDBJ | mRNA |