Q24025 · SOG_DROME

Function

function

Putative negative growth factor (PubMed:7958919).
Antagonist of dpp, a protein involved in patterning the dorsal region and in the development of the neuroectoderm; dpp inhibition is enhanced by tsg (PubMed:7958919).
Required for establishment of a narrow stripe of peak levels of BMP signaling in the dorsal midline of early embryos, that will give rise to the amnioserosa (PubMed:11260716).
During pupal development, plays a role in specification of the posterior crossvein in the wing (PubMed:15872004).
Exhibits both agonist and antagonist activities towards BMP signaling during pupal wing patterning (PubMed:15872004).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Cellular ComponentGolgi membrane
Cellular Componentplasma membrane
Molecular FunctionBMP binding
Molecular Functioncollagen binding
Molecular Functiongrowth factor activity
Molecular Functionprotein sequestering activity
Biological Processamnioserosa formation
Biological Processdorsal/ventral pattern formation
Biological Processestablishment of protein localization to extracellular region
Biological Processimaginal disc-derived wing vein morphogenesis
Biological Processmaternal specification of dorsal/ventral axis, oocyte, soma encoded
Biological Processnegative regulation of BMP signaling pathway
Biological Processpositive regulation of BMP signaling pathway
Biological Processposterior Malpighian tubule development
Biological Processregulation of imaginal disc-derived wing vein specification
Biological Processring gland development

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dorsal-ventral patterning protein Sog
  • Alternative names
    • Short gastrulation protein

Gene names

    • Name
      sog
    • ORF names
      CG9224

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q24025
  • Secondary accessions
    • B7FNI9
    • Q9VXS7

Proteomes

Organism-specific databases

Subcellular Location

Golgi apparatus membrane
; Single-pass type II membrane protein
Cell membrane
; Single-pass type I membrane protein
Secreted

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-53Cytoplasmic
Transmembrane54-74Helical; Signal-anchor for type II membrane protein
Topological domain75-1038Extracellular

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis27No change in baseline secretion but eliminates increased secretion normally caused by coexpression with Hip14 and reduces intracellular levels of Sog.
Mutagenesis28No effect on secretion when coexpressed with Hip14.

PTM/Processing

Features

Showing features for chain, glycosylation.

Type
IDPosition(s)Description
ChainPRO_00002190891-1038Dorsal-ventral patterning protein Sog
Glycosylation179N-linked (GlcNAc...) asparagine
Glycosylation287N-linked (GlcNAc...) asparagine
Glycosylation520N-linked (GlcNAc...) asparagine
Glycosylation666N-linked (GlcNAc...) asparagine
Glycosylation752N-linked (GlcNAc...) asparagine
Glycosylation821N-linked (GlcNAc...) asparagine

Post-translational modification

Palmitoylated, probably by Hip14.
Cleaved by metalloproteases tok and tld (PubMed:15872004).
Cleavage by tok during pupal development contributes to specification of the posterior crossvein in the wing (PubMed:15872004).

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Abuts the dorsal dpp-expressing cells in a lateral stripe 14-16 cells wide. Later in embryogenesis it is expressed in neuroectoderm and in the endoderm spaced along the anterior-posterior axis of the developing gut.

Developmental stage

Embryogenesis.

Gene expression databases

Interaction

Subunit

Component of a complex composed of dpp, sog and tsg (PubMed:11260716).
Interacts with palmitoyltransferase Hip14 (PubMed:20599894).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY Q24025vkg O184072EBI-184947, EBI-15721782

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain100-175VWFC 1
Domain197-337CHRD 1
Domain339-471CHRD 2
Domain474-588CHRD 3
Domain592-713CHRD 4
Domain742-804VWFC 2
Domain830-899VWFC 3
Domain939-1020VWFC 4

Sequence similarities

Belongs to the chordin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,038
  • Mass (Da)
    115,515
  • Last updated
    1996-11-01 v1
  • Checksum
    B0E833AFD79A9037
MANKLRKSNAIEWATATGTVPLLERSCCHSEDAALEPQASKTSHREQAPILRHLSQLSHLLIIAGLLIVCLAGVTEGRRHAPLMFEESDTGRRSNRPAVTECQFGKVLRELGSTWYADLGPPFGVMYCIKCECVAIPKKRRIVARVQCRNIKNECPPAKCDDPISLPGKCCKTCPGDRNDTDVALDVPVPNEEEERNMKHYAALLTGRTSYFLKGEEMKSMYTTYNPQNVVATARFLFHKKNLYYSFYTSSRIGRPRAIQFVDDAGVILEEHQLETTLAGTLSVYQNATGKICGVWRRVPRDYKRILRDDRLHVVLLWGNKQQAELALAGKVAKYTALQTELFSSLLEAPLPDGKTDPQLAGAGGTAIVSTSSGAASSMHLTLVFNGVFGAEEYADAALSVKIELAERKEVIFDEIPRVRKPSAEINVLELSSPISIQNLRLMSRGKLLLTVESKKYPHLRIQGHIVTRASCEIFQTLLAPHSAESSTKSSGLAWVYLNTDGSLAYNIETEHVNTRDRPNISLIEEQGKRKAKLEDLTPSFNFNQAIGSVEKLGPKVLESLYAGELGVNVATEHETSLIRGRLVPRPVADARDSAEPILLKRQEHTDAQNPHAVGMAWMSIDNECNLHYEVTLNGVPAQDLQLYLEEKPIEAIGAPVTRKLLEEFNGSYLEGFFLSMPSAELIKLEMSVCYLEVHSKHSKQLLLRGKLKSTKVPGHCFPVYTDNNVPVPGDHNDNHLVNGETKCFHSGRFYNESEQWRSAQDSCQMCACLRGQSSCEVIKCPALKCKSTEQLLQRDGECCPSCVPKKEAADYSAQSSPATNATDLLQQRRGCRLGEQFHPAGASWHPFLPPNGFDTCTTCSCDPLTLEIRCPRLVCPPLQCSEKLAYRPDKKACCKICPEGKQSSSNGHKTTPNNPNVLQDQAMQRSPSHSAEEVLANGGCKVVNKVYENGQEWHPILMSHGEQKCIKCRCKDSKVNCDRKRCSRSTCQQQTRVTSKRRLFEKPDAAAPAIDECCSTQCRRSRRHHKRQPHHQQRSSS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
M9PH73M9PH73_DROMEsog1038

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U18774
EMBL· GenBank· DDBJ
AAA89117.1
EMBL· GenBank· DDBJ
mRNA
AE014298
EMBL· GenBank· DDBJ
AAF48481.1
EMBL· GenBank· DDBJ
Genomic DNA
BT053679
EMBL· GenBank· DDBJ
ACK77594.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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