Q24025 · SOG_DROME
- ProteinDorsal-ventral patterning protein Sog
- Genesog
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1038 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Putative negative growth factor (PubMed:7958919).
Antagonist of dpp, a protein involved in patterning the dorsal region and in the development of the neuroectoderm; dpp inhibition is enhanced by tsg (PubMed:7958919).
Required for establishment of a narrow stripe of peak levels of BMP signaling in the dorsal midline of early embryos, that will give rise to the amnioserosa (PubMed:11260716).
During pupal development, plays a role in specification of the posterior crossvein in the wing (PubMed:15872004).
Exhibits both agonist and antagonist activities towards BMP signaling during pupal wing patterning (PubMed:15872004).
Antagonist of dpp, a protein involved in patterning the dorsal region and in the development of the neuroectoderm; dpp inhibition is enhanced by tsg (PubMed:7958919).
Required for establishment of a narrow stripe of peak levels of BMP signaling in the dorsal midline of early embryos, that will give rise to the amnioserosa (PubMed:11260716).
During pupal development, plays a role in specification of the posterior crossvein in the wing (PubMed:15872004).
Exhibits both agonist and antagonist activities towards BMP signaling during pupal wing patterning (PubMed:15872004).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Cellular Component | Golgi membrane | |
Cellular Component | plasma membrane | |
Molecular Function | BMP binding | |
Molecular Function | collagen binding | |
Molecular Function | growth factor activity | |
Molecular Function | protein sequestering activity | |
Biological Process | amnioserosa formation | |
Biological Process | dorsal/ventral pattern formation | |
Biological Process | establishment of protein localization to extracellular region | |
Biological Process | imaginal disc-derived wing vein morphogenesis | |
Biological Process | maternal specification of dorsal/ventral axis, oocyte, soma encoded | |
Biological Process | negative regulation of BMP signaling pathway | |
Biological Process | positive regulation of BMP signaling pathway | |
Biological Process | posterior Malpighian tubule development | |
Biological Process | regulation of imaginal disc-derived wing vein specification | |
Biological Process | ring gland development |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDorsal-ventral patterning protein Sog
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ24025
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus membrane ; Single-pass type II membrane protein
Cell membrane ; Single-pass type I membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 1-53 | Cytoplasmic | |||
Transmembrane | 54-74 | Helical; Signal-anchor for type II membrane protein | |||
Topological domain | 75-1038 | Extracellular | |||
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Mutagenesis | 27 | No change in baseline secretion but eliminates increased secretion normally caused by coexpression with Hip14 and reduces intracellular levels of Sog. | |||
Mutagenesis | 28 | No effect on secretion when coexpressed with Hip14. | |||
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000219089 | 1-1038 | Dorsal-ventral patterning protein Sog | ||
Glycosylation | 179 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 287 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 520 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 666 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 752 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 821 | N-linked (GlcNAc...) asparagine | |||
Post-translational modification
Palmitoylated, probably by Hip14.
Cleaved by metalloproteases tok and tld (PubMed:15872004).
Cleavage by tok during pupal development contributes to specification of the posterior crossvein in the wing (PubMed:15872004).
Cleavage by tok during pupal development contributes to specification of the posterior crossvein in the wing (PubMed:15872004).
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Abuts the dorsal dpp-expressing cells in a lateral stripe 14-16 cells wide. Later in embryogenesis it is expressed in neuroectoderm and in the endoderm spaced along the anterior-posterior axis of the developing gut.
Developmental stage
Embryogenesis.
Gene expression databases
Interaction
Subunit
Component of a complex composed of dpp, sog and tsg (PubMed:11260716).
Interacts with palmitoyltransferase Hip14 (PubMed:20599894).
Interacts with palmitoyltransferase Hip14 (PubMed:20599894).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | Q24025 | vkg O18407 | 2 | EBI-184947, EBI-15721782 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 100-175 | VWFC 1 | |||
Domain | 197-337 | CHRD 1 | |||
Domain | 339-471 | CHRD 2 | |||
Domain | 474-588 | CHRD 3 | |||
Domain | 592-713 | CHRD 4 | |||
Domain | 742-804 | VWFC 2 | |||
Domain | 830-899 | VWFC 3 | |||
Domain | 939-1020 | VWFC 4 | |||
Sequence similarities
Belongs to the chordin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,038
- Mass (Da)115,515
- Last updated1996-11-01 v1
- ChecksumB0E833AFD79A9037
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
M9PH73 | M9PH73_DROME | sog | 1038 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U18774 EMBL· GenBank· DDBJ | AAA89117.1 EMBL· GenBank· DDBJ | mRNA | ||
AE014298 EMBL· GenBank· DDBJ | AAF48481.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BT053679 EMBL· GenBank· DDBJ | ACK77594.1 EMBL· GenBank· DDBJ | mRNA |