Q23590 · BAZ2_CAEEL

  • Protein
    Bromodomain adjacent to zinc finger domain protein 2
  • Gene
    baz-2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Chromatin reader protein, involved in positively modulating the rate of age-related behavioral deterioration (PubMed:32103178).
Positively modulates the level of global trimethylated 'Lys-9' of histone H3 (H3K9me3), but not of H3K9me2 or H3K9me1 (PubMed:32103178).
May repress the expression of mitochondrial function-related genes by occupying their promoter regions, working in concert with histone methyltransferase, set-6 (PubMed:32103178).
Involved in modulation of the mitochondrial unfolded protein response (UPR) (PubMed:32103178).
Negatively regulates expression of bas-1, a serotonin (5-HT) and dopamine synthesizing enzyme (DOPA decarboxylase), with aging (PubMed:32103178).
Negatively modulates levels of endogenous 5-HT and dopamine with aging (PubMed:32103178).
Involved in modulating longevity, probably as a result of enhanced stress resistance via mechanisms related to dietary restriction and mitochondrial function (PubMed:32103178).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromatin
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular Functionmetal ion binding
Biological Processepigenetic regulation of gene expression

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Bromodomain adjacent to zinc finger domain protein 2

Gene names

    • Name
      baz-2
    • Synonyms
      flt-1
    • ORF names
      ZK783.4

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    Q23590

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

RNAi-mediated knockdown prevents age-related decline in the expression of bas-1, a serotonin (5-HT) and dopamine synthesizing enzyme (DOPA decarboxylase) (PubMed:32103178).
RNAi-mediated knockdown improves behavioral performance in pharyngeal pumping in aged worms (PubMed:32103178).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004521761-1390Bromodomain adjacent to zinc finger domain protein 2

Proteomic databases

Expression

Tissue specificity

Broadly expressed in the nervous system, including head, body and tail neurons.

Developmental stage

Expression increases with age.

Gene expression databases

    • WBGene00001470Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues

Interaction

Subunit

Interacts with set-6.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain, zinc finger.

TypeIDPosition(s)Description
Region30-67Disordered
Region178-215Disordered
Compositional bias185-215Polar residues
Region235-269Disordered
Compositional bias242-269Basic and acidic residues
Domain323-395MBD
Domain524-588DDT
Compositional bias705-720Basic and acidic residues
Region705-729Disordered
Zinc finger1100-1149PHD-type
Compositional bias1218-1232Basic and acidic residues
Region1218-1241Disordered
Domain1290-1360Bromo

Sequence similarities

Belongs to the WAL family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,390
  • Mass (Da)
    156,593
  • Last updated
    2012-05-16 v4
  • Checksum
    5D05420388A61B3B
MSDNSSNQFLLLLAAAQQQQQQQLLQQQLAKIQKATASSPSKSTNGTSASTSAVPSTSGTSSSQNEAAQLQNLAKMQQIQQLAQFGALMAAQKKQQEKAAADKAKEKEKEKQKAAAAAAAAAAKASASTSSASAIPGLSPEMLAAWQQAIQMQALQQMMMTPQKSQMEEAIKKMMDMAKKKPAGVASTSSASTSSSTPSTSSASITSSNNNAANNAASNMMNNVMWQLVAAQMQQKQQQQQKDTQKKADQAKKAKELAKQQQKEQDVKNKQQEEILKFLMAQHQLNHQKKHEKKQADAAALAAKVLAAHRAALESDSPEEGKKTNEAMLRLPLQLGWRRQTCVRSIASAGVKGDVSYFAPCGKKLSTYSEVVRYLTKNSIHYITRDNFLFNTKLVIGEFIVPKQTEADETQQEREFAMFTEDDINKELTRLNVLKFVPKIQASTSNGVHEDDIKMSKIEEPDEPLDPSELNDEFTEELVHSQIMSNGVDECKIREREADDLLVNINDVRHLPDFSRIGNQCLSSQGFADALMVHEFVQNFGHVLGIDLEIAPKLESLCAGLDGDANHAEQTLQLTRQLLRLALEFPGMGNEKRFGQGGGEMGLDRENFSEVMRLFLIDKGKRGEELSQPLLTCNFLSISPEQKASILAFLCDELVCSRNVVTEIDKNLDEISRLKGEKWMREGKARALRSARSKKKNDEKVVVVKEEQNHESDSEPPTRPDTPKKATVAPPTVVSVSPVSAAQQQQRKFTPGLGQCEVLTEQEESMSLQQMDSLIGDLHQEAQNINQKIHDTGLKIRSFPFGTDRFHRNYWMLAHTDKVIIESLATTSVNNPACNANEYASKDPPTLEQRVPGACETIDLDVIACVEDLVDDVVLLRAKADKKTRKRYRRIENHMKRGWWTMQNRDCVESLRSCMLSRGIRERALHRLLTKPWFLNELKFGTITIEPVGEKSDLELVRRQGWTRLNTAIDKLQCHLKMSDVSKPLPSITPFETQKPIVVPPTMALAQIVKDDMAWKVIDEEVDGQELDETIIRQKIIETADMVQPKFWRPKFQKLEDQDTCQLFEDWKSYVSTEAQTTSQLMVALQTLEGMIMWERSSREALCQICKSMDGDEMLVCDGCESGCHMECFRPRMTKVPEGDWFCQRCREEKSGRPMCMFCSRETGNLHQCQRCAYHVHQECSQDGPKEAINPETFICGHCQEMKQMRFVKRLILRSESEERELEDDNHAENGENTKNGHMNGMNGAIAIGVHNQQNGVKGNLKRKLEVPSIGGLPKNMNKELCQLMLDELVVQANALPFLEPVNPKLVPGYKMIISKPMDLKTIRQKNEKLIYETPEDFAEDIELMFANCRQFNIDHSEIGRAGISLHKFFQKRWKQLKYNFTKRLRRLHR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias185-215Polar residues
Compositional bias242-269Basic and acidic residues
Compositional bias705-720Basic and acidic residues
Compositional bias1218-1232Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX284603
EMBL· GenBank· DDBJ
CCD65251.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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