Q23590 · BAZ2_CAEEL
- ProteinBromodomain adjacent to zinc finger domain protein 2
- Genebaz-2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1390 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Chromatin reader protein, involved in positively modulating the rate of age-related behavioral deterioration (PubMed:32103178).
Positively modulates the level of global trimethylated 'Lys-9' of histone H3 (H3K9me3), but not of H3K9me2 or H3K9me1 (PubMed:32103178).
May repress the expression of mitochondrial function-related genes by occupying their promoter regions, working in concert with histone methyltransferase, set-6 (PubMed:32103178).
Involved in modulation of the mitochondrial unfolded protein response (UPR) (PubMed:32103178).
Negatively regulates expression of bas-1, a serotonin (5-HT) and dopamine synthesizing enzyme (DOPA decarboxylase), with aging (PubMed:32103178).
Negatively modulates levels of endogenous 5-HT and dopamine with aging (PubMed:32103178).
Involved in modulating longevity, probably as a result of enhanced stress resistance via mechanisms related to dietary restriction and mitochondrial function (PubMed:32103178).
Positively modulates the level of global trimethylated 'Lys-9' of histone H3 (H3K9me3), but not of H3K9me2 or H3K9me1 (PubMed:32103178).
May repress the expression of mitochondrial function-related genes by occupying their promoter regions, working in concert with histone methyltransferase, set-6 (PubMed:32103178).
Involved in modulation of the mitochondrial unfolded protein response (UPR) (PubMed:32103178).
Negatively regulates expression of bas-1, a serotonin (5-HT) and dopamine synthesizing enzyme (DOPA decarboxylase), with aging (PubMed:32103178).
Negatively modulates levels of endogenous 5-HT and dopamine with aging (PubMed:32103178).
Involved in modulating longevity, probably as a result of enhanced stress resistance via mechanisms related to dietary restriction and mitochondrial function (PubMed:32103178).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chromatin | |
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | metal ion binding | |
Biological Process | epigenetic regulation of gene expression |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameBromodomain adjacent to zinc finger domain protein 2
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ23590
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000452176 | 1-1390 | Bromodomain adjacent to zinc finger domain protein 2 | |||
Sequence: MSDNSSNQFLLLLAAAQQQQQQQLLQQQLAKIQKATASSPSKSTNGTSASTSAVPSTSGTSSSQNEAAQLQNLAKMQQIQQLAQFGALMAAQKKQQEKAAADKAKEKEKEKQKAAAAAAAAAAKASASTSSASAIPGLSPEMLAAWQQAIQMQALQQMMMTPQKSQMEEAIKKMMDMAKKKPAGVASTSSASTSSSTPSTSSASITSSNNNAANNAASNMMNNVMWQLVAAQMQQKQQQQQKDTQKKADQAKKAKELAKQQQKEQDVKNKQQEEILKFLMAQHQLNHQKKHEKKQADAAALAAKVLAAHRAALESDSPEEGKKTNEAMLRLPLQLGWRRQTCVRSIASAGVKGDVSYFAPCGKKLSTYSEVVRYLTKNSIHYITRDNFLFNTKLVIGEFIVPKQTEADETQQEREFAMFTEDDINKELTRLNVLKFVPKIQASTSNGVHEDDIKMSKIEEPDEPLDPSELNDEFTEELVHSQIMSNGVDECKIREREADDLLVNINDVRHLPDFSRIGNQCLSSQGFADALMVHEFVQNFGHVLGIDLEIAPKLESLCAGLDGDANHAEQTLQLTRQLLRLALEFPGMGNEKRFGQGGGEMGLDRENFSEVMRLFLIDKGKRGEELSQPLLTCNFLSISPEQKASILAFLCDELVCSRNVVTEIDKNLDEISRLKGEKWMREGKARALRSARSKKKNDEKVVVVKEEQNHESDSEPPTRPDTPKKATVAPPTVVSVSPVSAAQQQQRKFTPGLGQCEVLTEQEESMSLQQMDSLIGDLHQEAQNINQKIHDTGLKIRSFPFGTDRFHRNYWMLAHTDKVIIESLATTSVNNPACNANEYASKDPPTLEQRVPGACETIDLDVIACVEDLVDDVVLLRAKADKKTRKRYRRIENHMKRGWWTMQNRDCVESLRSCMLSRGIRERALHRLLTKPWFLNELKFGTITIEPVGEKSDLELVRRQGWTRLNTAIDKLQCHLKMSDVSKPLPSITPFETQKPIVVPPTMALAQIVKDDMAWKVIDEEVDGQELDETIIRQKIIETADMVQPKFWRPKFQKLEDQDTCQLFEDWKSYVSTEAQTTSQLMVALQTLEGMIMWERSSREALCQICKSMDGDEMLVCDGCESGCHMECFRPRMTKVPEGDWFCQRCREEKSGRPMCMFCSRETGNLHQCQRCAYHVHQECSQDGPKEAINPETFICGHCQEMKQMRFVKRLILRSESEERELEDDNHAENGENTKNGHMNGMNGAIAIGVHNQQNGVKGNLKRKLEVPSIGGLPKNMNKELCQLMLDELVVQANALPFLEPVNPKLVPGYKMIISKPMDLKTIRQKNEKLIYETPEDFAEDIELMFANCRQFNIDHSEIGRAGISLHKFFQKRWKQLKYNFTKRLRRLHR |
Proteomic databases
Expression
Tissue specificity
Broadly expressed in the nervous system, including head, body and tail neurons.
Developmental stage
Expression increases with age.
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 30-67 | Disordered | ||||
Sequence: AKIQKATASSPSKSTNGTSASTSAVPSTSGTSSSQNEA | ||||||
Region | 178-215 | Disordered | ||||
Sequence: AKKKPAGVASTSSASTSSSTPSTSSASITSSNNNAANN | ||||||
Compositional bias | 185-215 | Polar residues | ||||
Sequence: VASTSSASTSSSTPSTSSASITSSNNNAANN | ||||||
Region | 235-269 | Disordered | ||||
Sequence: QKQQQQQKDTQKKADQAKKAKELAKQQQKEQDVKN | ||||||
Compositional bias | 242-269 | Basic and acidic residues | ||||
Sequence: KDTQKKADQAKKAKELAKQQQKEQDVKN | ||||||
Domain | 323-395 | MBD | ||||
Sequence: KTNEAMLRLPLQLGWRRQTCVRSIASAGVKGDVSYFAPCGKKLSTYSEVVRYLTKNSIHYITRDNFLFNTKLV | ||||||
Domain | 524-588 | DDT | ||||
Sequence: SQGFADALMVHEFVQNFGHVLGIDLEIAPKLESLCAGLDGDANHAEQTLQLTRQLLRLALEFPGM | ||||||
Compositional bias | 705-720 | Basic and acidic residues | ||||
Sequence: KEEQNHESDSEPPTRP | ||||||
Region | 705-729 | Disordered | ||||
Sequence: KEEQNHESDSEPPTRPDTPKKATVA | ||||||
Zinc finger | 1100-1149 | PHD-type | ||||
Sequence: EALCQICKSMDGDEMLVCDGCESGCHMECFRPRMTKVPEGDWFCQRCREE | ||||||
Compositional bias | 1218-1232 | Basic and acidic residues | ||||
Sequence: EERELEDDNHAENGE | ||||||
Region | 1218-1241 | Disordered | ||||
Sequence: EERELEDDNHAENGENTKNGHMNG | ||||||
Domain | 1290-1360 | Bromo | ||||
Sequence: VVQANALPFLEPVNPKLVPGYKMIISKPMDLKTIRQKNEKLIYETPEDFAEDIELMFANCRQFNIDHSEIG |
Sequence similarities
Belongs to the WAL family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,390
- Mass (Da)156,593
- Last updated2012-05-16 v4
- Checksum5D05420388A61B3B
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 185-215 | Polar residues | ||||
Sequence: VASTSSASTSSSTPSTSSASITSSNNNAANN | ||||||
Compositional bias | 242-269 | Basic and acidic residues | ||||
Sequence: KDTQKKADQAKKAKELAKQQQKEQDVKN | ||||||
Compositional bias | 705-720 | Basic and acidic residues | ||||
Sequence: KEEQNHESDSEPPTRP | ||||||
Compositional bias | 1218-1232 | Basic and acidic residues | ||||
Sequence: EERELEDDNHAENGE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX284603 EMBL· GenBank· DDBJ | CCD65251.2 EMBL· GenBank· DDBJ | Genomic DNA |