Q23551 · UNC22_CAEEL
- ProteinTwitchin
- Geneunc-22
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids7158 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Regulator of muscle contraction and relaxation. Senses mechanical strain that occurs during muscle activity by unfolding in clearly resolvable steps at differing forces (PubMed:18390597, PubMed:7190524).
Plays a role in the organization of sarcomeres in body wall muscles (PubMed:25851606).
Plays a role in the organization of sarcomeres in body wall muscles (PubMed:25851606).
Miscellaneous
Determination of the mutation frequency of the unc-22 gene has been used to study the biological effects of short duration spaceflight.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Activity regulation
Forces generated by the contraction/relaxation cycles of muscle activity separate the regulatory domain from the catalytic core, activating the enzyme. At rest, the kinase domain is in a closed conformation. The active site is occupied by the autoinhibitory region (CDR), which makes extensive contact with the catalytic site, blocking substrate binding. At low forces the regulatory tail will unravel reversibly and expose the active site to its substrates, potentially stabilized by binding of Ca/CALM. At high forces the kinase begins to unfold and the integrity of the active site is disrupted.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | A band | |
Molecular Function | ATP binding | |
Molecular Function | calmodulin binding | |
Molecular Function | metal ion binding | |
Molecular Function | protein kinase binding | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | adult locomotory behavior | |
Biological Process | behavioral response to nicotine | |
Biological Process | negative regulation of cell division | |
Biological Process | positive regulation of locomotion | |
Biological Process | positive regulation of sarcomere organization | |
Biological Process | positive regulation of striated muscle contraction | |
Biological Process | sarcomere organization |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTwitchin
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ23551
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Expressed at the outer edge of A-bands.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Body muscles are unable to develop or sustain normal contractions but small regions within the myofilament lattice of individual muscle cells contract transiently in the absence of contraction of the adjacent lattice (PubMed:16765996, PubMed:7190524).
This results in a nearly constant body twitching phenotype (PubMed:16765996, PubMed:25851606, PubMed:7190524).
Resistant to nicotine-induced paralysis (PubMed:25851606).
This results in a nearly constant body twitching phenotype (PubMed:16765996, PubMed:25851606, PubMed:7190524).
Resistant to nicotine-induced paralysis (PubMed:25851606).
PTM/Processing
Features
Showing features for chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000404604 | 1-7158 | Twitchin | |||
Sequence: MVGAPRFTQKPSIQQTPTGDLLMECHLEADPQPTIAWQHSGNLLEPSGRVVQTLTPLGGSLYKATLVIKEPNAGDGGAYKCTARNQLGESNANINLNFAGAGGDEAKSRGPSFVGKPRIIPKDGGALIVMECKVKSASTPVAKWMKDGVPLSMGGLYHAIFSDLGDQTYLCQLEIRGPSSSDAGQYRCNIRNDQGETNANLALNFEEPDPSERQERKRSTASPRPSSRGPGSRPSSPKKSMKSREGTPKRTLKPREGSPSKKLRSRTSTPVNEEVSQSESRRSSRTDKMEVDQVSGASKRKPDGLPPPGGDEKKLRAGSPSTRKSPSRKSASPTPSRKGSSAGGAASGTTGASASATSATSGGSASSDASRDKYTRPPIVLEASRSQTGRIGGSVVLEVQWQCHSSTIIEWYRDGTLVRNSSEYSQSFNGSIAKLQVNKLTEEKSGLYKCHAKCDYGEGQSSAMVKIEQSDVEEELMKHRKDAEDEYQKEEQKSQTLQAETKKRVARRSKSKSKSPAPQAKKSTTSESGRQEASEVEHKRSSSVRPDPDEESQLDEIPSSGLTIPEERRRELLGQVGESDDEVSESISELPSFAGGKPRRKTDSPPKQDDMFSRDTLLRKTTTSTKNESSTVEEKTKLRKTVKKVDGELDFKAMVKLKKVKKEEGGTTEKSGFPLDHADSTSSVLSQESRSRRGSNAPFAKDGLPEQPANPFAQLKKVKSGAGGLEKSDSMASLKKLDLKKGKIDDNSDGAFKVQLKKVVKKEVKESTISVKEKNGTESGIKTEFKMEKRERTTLQKYEKTDSDGSKKEDKPKKVSIAPVSTNKSSDDEPSTPRHHKEVEEKSTSEELKAKVAGRQVGQKRNGAQKPEEPKNLLSQIQLKKVTKKAHDDTNELEGIKLKKVTTVPKHVADDDSQSESESRRGSVFGELRRGSRAPRDSADNSRRDSIRRSSIDMRRESVQEILEKTSTPLVPSGASGSAPKIVEVPENVTVVENETAILTCKVSGSPAPTFRWFKGSREVISGGRFKHITDGKEHTVALALLKCRSQDEGPYTLTIENVHGTDSADVKLLVTSDNGLDFRAMLKHRESQAGFQKDGEGGGAGGGGGEKKPMTEAERRQSLFPGKKVEKWDIPLPEKTVQQQVDKICEWKCTYSRPNAKIRWYKDRKEIFSGGLKYKIVIEKNVCTLIINNPEVDDTGKYTCEANGVPTHAQLTVLEPPMKYSFLNPLPNTQEIYRTKQAVLTCKVNTPRAPLVWYRGSKAIQEGDPRFIIEKDAVGRCTLTIKEVEEDDQAEWTARITQDVFSKVQVYVEEPRHTFVVPMKSQKVNESDLATLETDVNDKDAEVVWWHDGKRIDIDGVKFKVESSNRKRRLIINGARIEDHGEYKCTTKDDRTMAQLIVDAKNKFIVALKDTEVIEKDDVTLMCQTKDTKTPGIWFRNGKQISSMPGGKFETQSRNGTHTLKIGKIEMNEADVYEIDQAGLRGSCNVTVLEAEKRPILNWKPKKIEAKAGEPCVVKVPFQIKGTRRGDPKAQILKNGKPIDEEMRKLVEVIIKDDVAEIVFKNPQLADTGKWALELGNSAGTALAPFELFVKDKPKPPKGPLETKNVTAEGLDLVWGTPDPDEGAPVKAYIIEMQEGRSGNWAKVGETKGTDFKVKDLKEHGEYKFRVKALNECGLSDPLTGESVLAKNPYGVPGKPKNMDAIDVDKDHCTLAWEPPEEDGGAPITGYIIERREKSEKDWHQVGQTKPDCCELTDKKVVEDKEYLYRVKAVNKAGPGDPCDHGKPIKMKAKKASPEFTGGGIKDLRLKVGETIKYDVPISGEPLPECLWVVNGKPLKAVGRVKMSSERGKHIMKIENAVRADSGKFTITLKNSSGSCDSTATVTVVGRPTPPKGPLDIADVCADGATLSWNPPDDDGGDPLTGYIVEAQDMDNKGKYIEVGKVDPNTTTLKVNGLRNKGNYKFRVKAVNNEGESEPLSADQYTQIKDPWDEPGKPGRPEITDFDADRIDIAWEPPHKDGGAPIEEYIVEVRDPDTKEWKEVKRVPDTNASISGLKEGKEYQFRVRAVNKAGPGQPSEPSEKQLAKPKFIPAWLKHDNLKSITVKAGATVRWEVKIGGEPIPEVKWFKGNQQLENGIQLTIDTRKNEHTILCIPSAMRSDVGEYRLTVKNSHGADEEKANLTVLDRPSKPNGPLEVSDVFEDNLNLSWKPPDDDGGEPIEYYEVEKLDTATGRWVPCAKVKDTKAHIDGLKKGQTYQFRVKAVNKEGASDALSTDKDTKAKNPYDEPGKTGTPDVVDWDADRVSLEWEPPKSDGGAPITQYVIEKKGKHGRDWQECGKVSGDQTNAEILGLKEGEEYQFRVKAVNKAGPGEASDPSRKVVAKPRNLKPWIDREAMKTITIKVGNDVEFDVPVRGEPPPKKEWIFNEKPVDDQKIRIESEDYKTRFVLRGATRKHAGLYTLTATNASGSDKHSVEVIVLGKPSSPLGPLEVSNVYEDRADLEWKVPEDDGGAPIDHYEIEKMDLATGRWVPCGRSETTKTTVPNLQPGHEYKFRVRAVNKEGESDPLTTNTAILAKNPYEVPGKVDKPELVDWDKDHVDLAWNAPDDGGAPIEAFVIEKKDKNGRWEEALVVPGDQKTATVPNLKEGEEYQFRISARNKAGTGDPSDPSDRVVAKPRNLAPRIHREDLSDTTVKVGATLKFIVHIDGEPAPDVTWSFNGKGIGESKAQIENEPYISRFALPKALRKQSGKYTITATNINGTDSVTINIKVKSKPTKPKGPIEVTDVFEDRATLDWKPPEDDGGEPIEFYEIEKMNTKDGIWVPCGRSGDTHFTVDSLNKGDHYKFRVKAVNSEGPSDPLETETDILAKNPFDRPDRPGRPEPTDWDSDHVDLKWDPPLSDGGAPIEEYQIEKRTKYGRWEPAITVPGGQTTATVPDLTPNEEYEFRVVAVNKGGPSDPSDASKAVIAKPRNLKPHIDRDALKNLTIKAGQSISFDVPVSGEPAPTVTWHWPDNREIRNGGRVKLDNPEYQSKLVVKQMERGDSGTFTIKAVNANGEDEATVKINVIDKPTSPNGPLDVSDVHGDHVTLNWRAPDDDGGIPIENYVIEKYDTASGRWVPAAKVAGDKTTAVVDGLIPGHEYKFRVAAVNAEGESDPLETFGTTLAKDPFDKPGKTNAPEITDWDKDHVDLEWKPPANDGGAPIEEYVVEMKDEFSPFWNDVAHVPAGQTNATVGNLKEGSKYEFRIRAKNKAGLGDPSDSASAVAKARNVPPVIDRNSIQEIKVKAGQDFSLNIPVSGEPTPTITWTFEGTPVESDDRMKLNNEDGKTKFHVKRALRSDTGTYIIKAENENGTDTAEVKVTVLDHPSSPRGPLDVTNIVKDGCDLAWKEPEDDGGAEISHYVIEKQDAATGRWTACGESKDTNFHVDDLTQGHEYKFRVKAVNRHGDSDPLEAREAIIAKDPFDRADKPGTPEIVDWDKDHADLKWTPPADDGGAPIEGYLVEMRTPSGDWVPAVTVGAGELTATVDGLKPGQTYQFRVKALNKAGESTPSDPSRTMVAKPRHLAPKINRDMFVAQRVKAGQTLNFDVNVEGEPAPKIEWFLNGSPLSSGGNTHIDNNTDNNTKLTTKSTARADSGKYKIVATNESGKDEHEVDVNILDIPGAPEGPLRHKDITKESVVLKWDEPLDDGGSPITNYVVEKQEDGGRWVPCGETSDTSLKVNKLSEGHEYKFRVKAVNRQGTSAPLTSDHAIVAKNPFDEPDAPTDVTPVDWDKDHVDLEWKPPANDGGAPIDAYIVEKKDKFGDWVECARVDGKTTKATADNLTPGETYQFRVKAVNKAGPGKPSDPTGNVVAKPRRMAPKLNLAGLLDLRIKAGTPIKLDIAFEGEPAPVAKWKANDATIDTGARADVTNTPTSSAIHIFSAVRGDTGVYKIIVENEHGKDTAQCNVTVLDVPGTPEGPLKIDEIHKEGCTLNWKPPTDNGGTDVLHYIVEKMDTSRGTWQEVGTFPDCTAKVNKLVPGKEYAFRVKAVNLQGESKPLEAEEPIIAKNQFDVPDPVDKPEVTDWDKDRIDIKWNPTANNGGAPVTGYIVEKKEKGSAIWTEAGKTPGTTFSADNLKPGVEYEFRVIAVNAAGPSDPSDPTDPQITKARYLKPKILTASRKIKIKAGFTHNLEVDFIGAPDPTATWTVGDSGAALAPELLVDAKSSTTSIFFPSAKRADSGNYKLKVKNELGEDEAIFEVIVQDRPSAPEGPLEVSDVTKDSCVLNWKPPKDDGGAEISNYVVEKRDTKTNTWVPVSAFVTGTSITVPKLTEGHEYEFRVMAENTFGRSDSLNTDEPVLAKDPFGTPGKPGRPEIVDTDNDHIDIKWDPPRDNGGSPVDHYDIERKDAKTGRWIKVNTSPVQGTAFSDTRVQKGHTYEYRVVAVNKAGPGQPSDSSAAATAKPMHEAPKFDLDLDGKEFRVKAGEPLVITIPFTASPQPDISWTKEGGKPLAGVETTDSQTKLVIPSTRRSDSGPVKIKAVNPYGEAEANIKITVIDKPGAPENITYPAVSRHTCTLNWDAPKDDGGAEIAGYKIEYQEVGSQIWDKVPGLISGTAYTVRGLEHGQQYRFRIRAENAVGLSDYCQGVPVVIKDPFDPPGAPSTPEITGYDTNQVSLAWNPPRDDGGSPILGYVVERFEKRGGGDWAPVKMPMVKGTECIVPGLHENETYQFRVRAVNAAGHGEPSNGSEPVTCRPYVEKPGAPDAPRVGKITKNSAELTWNRPLRDGGAPIDGYIVEKKKLGDNDWTRCNDKPVRDTAFEVKNLGEKEEYEFRVIAVNSAGEGEPSKPSDLVLIEEQPGRPIFDINNLKDITVRAGETIQIRIPYAGGNPKPIIDLFNGNSPIFENERTVVDVNPGEIVITTTGSKRSDAGPYKISATNKYGKDTCKLNVFVLDAPGKPTGPIRATDIQADAMTLSWRPPKDNGGDAITNYVVEKRTPGGDWVTVGHPVGTTLRVRNLDANTPYEFRVRAENQYGVGEPLETDDAIVAKNPFDTPGAPGQPEAVETSEEAITLQWTRPTSDGGAPIQGYVIEKREVGSTEWTKAAFGNILDTKHRVTGLTPKKTYEFRVAAYNAAGQGEYSVNSVPITADNAPTRPKINMGMLTRDILAYAGERAKILVPFAASPAPKVTFSKGENKISPTDPRVKVEYSDFLATLTIEKSELTDGGLYFVELENSQGSDSASIRLKVVDKPASPQHIRVEDIAPDCCTLYWMPPSSDGGSPITNYIVEKLDLRHSDGKWEKVSSFVRNLNYTVGGLIKDNRYRFRVRAETQYGVSEPCELADVVVAKYQFEVPNQPEAPTVRDKDSTWAELEWDPPRDGGSKIIGYQVQYRDTSSGRWINAKMDLSEQCHARVTGLRQNGEFEFRIIAKNAAGFSKPSPPSERCQLKSRFGPPGPPIHVGAKSIGRNHCTITWMAPLEDGGSKITGYNVEIREYGSTLWTVASDYNVREPEFTVDKLREFNDYEFRVVAINAAGKGIPSLPSGPIKIQESGGSRPQIVVKPEDTAQPYNRRAVFTCEAVGRPEPTARWLRNGRELPESSRYRFEASDGVYKFTIKEVWDIDAGEYTVEVSNPYGSDTATANLVVQAPPVIEKDVPNTILPSGDLVRLKIYFSGTAPFRHSLVLNREEIDMDHPTIRIVEFDDHILITIPALSVREAGRYEYTVSNDSGEATTGFWLNVTGLPEAPQGPLHISNIGPSTATLSWRPPVTDGGSKITSYVVEKRDLSKDEWVTVTSNVKDMNYIVTGLFENHEYEFRVSAQNENGIGAPLVSEHPIIARLPFDPPTSPLNLEIVQVGGDYVTLSWQRPLSDGGGRLRGYIVEKQEEEHDEWFRCNQNPSPPNNYNVPNLIDGRKYRYRVFAVNDAGLSDLAELDQTLFQASGSGEGPKIVSPLSDLNEEVGRCVTFECEISGSPRPEYRWFKGCKELVDTSKYTLINKGDKQVLIINDLTSDDADEYTCRATNSSGTRSTRANLRIKTKPRVFIPPKYHGGYEAQKGETIELKIPYKAYPQGEARWTKDGEKIENNSKFSITTDDKFATLRISNASREDYGEYRVVVENSVGSDSGTVNVTVADVPEPPRFPIIENILDEAVILSWKPPALDGGSLVTNYTIEKREAMGGSWSPCAKSRYTYTTIEGLRAGKQYEFRIIAENKHGQSKPCEPTAPVLIPGDERKRRRGYDVDEQGKIVRGKGTVSSNYDNYVFDIWKQYYPQPVEIKHDHVLDHYDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWLTPGNAPGRDSQIPSSRYTKIRDSIKTKYDAWPEPLPPLGRISNYSSLRKHRPQEYSIRDAFWDRSEAQPRFIVKPYGTEVGEGQSANFYCRVIASSPPVVTWHKDDRELKQSVKYMKRYNGNDYGLTINRVKGDDKGEYTVRAKNSYGTKEEIVFLNVTRHSEPLKFEPLEPMKKAPSPPRVEEFKERRSAPFFTFHLRNRLIQKNHQCKLTCSLQGNPNPTIEWMKDGHPVDEDRVQVSFRSGVCSLEIFNARVDDAGTYTVTATNDLGVDVSECVLTVQTKGGEPIPRVSSFRPRRAYDTLSTGTDVERSHSYADMRRRSLIRDVSPDVRSAADDLKTKITNELPSFTAQLSDSETEVGGSAEFSAAVSGQPEPLIEWLHNGERISESDSRFRASYVAGKATLRISDAKKSDEGQYLCRASNSAGQEQTRATLTVKGDQPLLNGHAGQAVESELRVTKHLGGEIVNNGESVTFEARVQGTPEEVLWMRNGQELTNGDKTSISQDGETLSFTINSADASDAGHYQLEVRSKGTNLVSVASLVVVGEKADPPVTRLPSSVSAPLGGSTAFTIEFENVEGLTVQWFRGSEKIEKNERVKSVKTGNTFKLDIKNVEQDDDGIYVAKVVKEKKAIAKYAAALLLV | ||||||
Disulfide bond | 25↔81 | |||||
Sequence: CHLEADPQPTIAWQHSGNLLEPSGRVVQTLTPLGGSLYKATLVIKEPNAGDGGAYKC | ||||||
Disulfide bond | 132↔188 | |||||
Sequence: CKVKSASTPVAKWMKDGVPLSMGGLYHAIFSDLGDQTYLCQLEIRGPSSSDAGQYRC | ||||||
Disulfide bond | 1150↔1201 | |||||
Sequence: CTYSRPNAKIRWYKDRKEIFSGGLKYKIVIEKNVCTLIINNPEVDDTGKYTC | ||||||
Disulfide bond | 5944↔5995 | |||||
Sequence: CEISGSPRPEYRWFKGCKELVDTSKYTLINKGDKQVLIINDLTSDDADEYTC |
Post-translational modification
Phosphorylated by mak-1 on the protein kinase domain and/or CDR domain in vitro.
Keywords
- PTM
Proteomic databases
Expression
Tissue specificity
Expressed in body wall, anal, vulval, and pharyngeal muscles (at protein level).
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 5-97 | Ig-like 1 | ||||
Sequence: PRFTQKPSIQQTPTGDLLMECHLEADPQPTIAWQHSGNLLEPSGRVVQTLTPLGGSLYKATLVIKEPNAGDGGAYKCTARNQLGESNANINLN | ||||||
Domain | 111-204 | Ig-like 2 | ||||
Sequence: PSFVGKPRIIPKDGGALIVMECKVKSASTPVAKWMKDGVPLSMGGLYHAIFSDLGDQTYLCQLEIRGPSSSDAGQYRCNIRNDQGETNANLALN | ||||||
Region | 204-381 | Disordered | ||||
Sequence: NFEEPDPSERQERKRSTASPRPSSRGPGSRPSSPKKSMKSREGTPKRTLKPREGSPSKKLRSRTSTPVNEEVSQSESRRSSRTDKMEVDQVSGASKRKPDGLPPPGGDEKKLRAGSPSTRKSPSRKSASPTPSRKGSSAGGAASGTTGASASATSATSGGSASSDASRDKYTRPPIVL | ||||||
Compositional bias | 208-222 | Basic and acidic residues | ||||
Sequence: PDPSERQERKRSTAS | ||||||
Compositional bias | 223-237 | Polar residues | ||||
Sequence: PRPSSRGPGSRPSSP | ||||||
Compositional bias | 238-262 | Basic and acidic residues | ||||
Sequence: KKSMKSREGTPKRTLKPREGSPSKK | ||||||
Compositional bias | 263-277 | Polar residues | ||||
Sequence: LRSRTSTPVNEEVSQ | ||||||
Compositional bias | 278-297 | Basic and acidic residues | ||||
Sequence: SESRRSSRTDKMEVDQVSGA | ||||||
Compositional bias | 320-371 | Polar residues | ||||
Sequence: PSTRKSPSRKSASPTPSRKGSSAGGAASGTTGASASATSATSGGSASSDASR | ||||||
Domain | 377-466 | Ig-like 3 | ||||
Sequence: PPIVLEASRSQTGRIGGSVVLEVQWQCHSSTIIEWYRDGTLVRNSSEYSQSFNGSIAKLQVNKLTEEKSGLYKCHAKCDYGEGQSSAMVK | ||||||
Compositional bias | 473-504 | Basic and acidic residues | ||||
Sequence: EEELMKHRKDAEDEYQKEEQKSQTLQAETKKR | ||||||
Region | 473-639 | Disordered | ||||
Sequence: EEELMKHRKDAEDEYQKEEQKSQTLQAETKKRVARRSKSKSKSPAPQAKKSTTSESGRQEASEVEHKRSSSVRPDPDEESQLDEIPSSGLTIPEERRRELLGQVGESDDEVSESISELPSFAGGKPRRKTDSPPKQDDMFSRDTLLRKTTTSTKNESSTVEEKTKLR | ||||||
Compositional bias | 516-530 | Polar residues | ||||
Sequence: PAPQAKKSTTSESGR | ||||||
Compositional bias | 531-552 | Basic and acidic residues | ||||
Sequence: QEASEVEHKRSSSVRPDPDEES | ||||||
Compositional bias | 562-577 | Basic and acidic residues | ||||
Sequence: LTIPEERRRELLGQVG | ||||||
Compositional bias | 600-616 | Basic and acidic residues | ||||
Sequence: RKTDSPPKQDDMFSRDT | ||||||
Region | 658-732 | Disordered | ||||
Sequence: KKVKKEEGGTTEKSGFPLDHADSTSSVLSQESRSRRGSNAPFAKDGLPEQPANPFAQLKKVKSGAGGLEKSDSMA | ||||||
Compositional bias | 674-694 | Polar residues | ||||
Sequence: PLDHADSTSSVLSQESRSRRG | ||||||
Repeat | 718-764 | Kelch 1 | ||||
Sequence: VKSGAGGLEKSDSMASLKKLDLKKGKIDDNSDGAFKVQLKKVVKKEV | ||||||
Compositional bias | 763-815 | Basic and acidic residues | ||||
Sequence: EVKESTISVKEKNGTESGIKTEFKMEKRERTTLQKYEKTDSDGSKKEDKPKKV | ||||||
Region | 763-955 | Disordered | ||||
Sequence: EVKESTISVKEKNGTESGIKTEFKMEKRERTTLQKYEKTDSDGSKKEDKPKKVSIAPVSTNKSSDDEPSTPRHHKEVEEKSTSEELKAKVAGRQVGQKRNGAQKPEEPKNLLSQIQLKKVTKKAHDDTNELEGIKLKKVTTVPKHVADDDSQSESESRRGSVFGELRRGSRAPRDSADNSRRDSIRRSSIDMR | ||||||
Compositional bias | 828-849 | Basic and acidic residues | ||||
Sequence: DEPSTPRHHKEVEEKSTSEELK | ||||||
Compositional bias | 881-955 | Basic and acidic residues | ||||
Sequence: KVTKKAHDDTNELEGIKLKKVTTVPKHVADDDSQSESESRRGSVFGELRRGSRAPRDSADNSRRDSIRRSSIDMR | ||||||
Domain | 980-1072 | Ig-like 4 | ||||
Sequence: PKIVEVPENVTVVENETAILTCKVSGSPAPTFRWFKGSREVISGGRFKHITDGKEHTVALALLKCRSQDEGPYTLTIENVHGTDSADVKLLVT | ||||||
Region | 1088-1118 | Disordered | ||||
Sequence: SQAGFQKDGEGGGAGGGGGEKKPMTEAERRQ | ||||||
Domain | 1122-1213 | Ig-like 5 | ||||
Sequence: PGKKVEKWDIPLPEKTVQQQVDKICEWKCTYSRPNAKIRWYKDRKEIFSGGLKYKIVIEKNVCTLIINNPEVDDTGKYTCEANGVPTHAQLT | ||||||
Domain | 1217-1306 | Ig-like 6 | ||||
Sequence: PPMKYSFLNPLPNTQEIYRTKQAVLTCKVNTPRAPLVWYRGSKAIQEGDPRFIIEKDAVGRCTLTIKEVEEDDQAEWTARITQDVFSKVQ | ||||||
Domain | 1312-1398 | Ig-like 7 | ||||
Sequence: PRHTFVVPMKSQKVNESDLATLETDVNDKDAEVVWWHDGKRIDIDGVKFKVESSNRKRRLIINGARIEDHGEYKCTTKDDRTMAQLI | ||||||
Domain | 1598-1690 | Fibronectin type-III 1 | ||||
Sequence: PKGPLETKNVTAEGLDLVWGTPDPDEGAPVKAYIIEMQEGRSGNWAKVGETKGTDFKVKDLKEHGEYKFRVKALNECGLSDPLTGESVLAKNP | ||||||
Domain | 1696-1791 | Fibronectin type-III 2 | ||||
Sequence: KPKNMDAIDVDKDHCTLAWEPPEEDGGAPITGYIIERREKSEKDWHQVGQTKPDCCELTDKKVVEDKEYLYRVKAVNKAGPGDPCDHGKPIKMKAK | ||||||
Domain | 1891-1988 | Fibronectin type-III 3 | ||||
Sequence: PPKGPLDIADVCADGATLSWNPPDDDGGDPLTGYIVEAQDMDNKGKYIEVGKVDPNTTTLKVNGLRNKGNYKFRVKAVNNEGESEPLSADQYTQIKDP | ||||||
Domain | 1994-2087 | Fibronectin type-III 4 | ||||
Sequence: KPGRPEITDFDADRIDIAWEPPHKDGGAPIEEYIVEVRDPDTKEWKEVKRVPDTNASISGLKEGKEYQFRVRAVNKAGPGQPSEPSEKQLAKPK | ||||||
Repeat | 2014-2058 | Kelch 2 | ||||
Sequence: PPHKDGGAPIEEYIVEVRDPDTKEWKEVKRVPDTNASISGLKEGK | ||||||
Domain | 2086-2181 | Ig-like 8 | ||||
Sequence: PKFIPAWLKHDNLKSITVKAGATVRWEVKIGGEPIPEVKWFKGNQQLENGIQLTIDTRKNEHTILCIPSAMRSDVGEYRLTVKNSHGADEEKANLT | ||||||
Domain | 2189-2282 | Fibronectin type-III 5 | ||||
Sequence: PNGPLEVSDVFEDNLNLSWKPPDDDGGEPIEYYEVEKLDTATGRWVPCAKVKDTKAHIDGLKKGQTYQFRVKAVNKEGASDALSTDKDTKAKNP | ||||||
Repeat | 2207-2253 | Kelch 3 | ||||
Sequence: WKPPDDDGGEPIEYYEVEKLDTATGRWVPCAKVKDTKAHIDGLKKGQ | ||||||
Region | 2266-2295 | Disordered | ||||
Sequence: GASDALSTDKDTKAKNPYDEPGKTGTPDVV | ||||||
Compositional bias | 2269-2283 | Basic and acidic residues | ||||
Sequence: DALSTDKDTKAKNPY | ||||||
Domain | 2288-2383 | Fibronectin type-III 6 | ||||
Sequence: KTGTPDVVDWDADRVSLEWEPPKSDGGAPITQYVIEKKGKHGRDWQECGKVSGDQTNAEILGLKEGEEYQFRVKAVNKAGPGEASDPSRKVVAKPR | ||||||
Domain | 2483-2576 | Fibronectin type-III 7 | ||||
Sequence: PLGPLEVSNVYEDRADLEWKVPEDDGGAPIDHYEIEKMDLATGRWVPCGRSETTKTTVPNLQPGHEYKFRVRAVNKEGESDPLTTNTAILAKNP | ||||||
Repeat | 2502-2547 | Kelch 4 | ||||
Sequence: KVPEDDGGAPIDHYEIEKMDLATGRWVPCGRSETTKTTVPNLQPGH | ||||||
Domain | 2579-2675 | Fibronectin type-III 8 | ||||
Sequence: VPGKVDKPELVDWDKDHVDLAWNAPDDGGAPIEAFVIEKKDKNGRWEEALVVPGDQKTATVPNLKEGEEYQFRISARNKAGTGDPSDPSDRVVAKPR | ||||||
Domain | 2679-2763 | Ig-like 9 | ||||
Sequence: PRIHREDLSDTTVKVGATLKFIVHIDGEPAPDVTWSFNGKGIGESKAQIENEPYISRFALPKALRKQSGKYTITATNINGTDSVT | ||||||
Domain | 2775-2868 | Fibronectin type-III 9 | ||||
Sequence: PKGPIEVTDVFEDRATLDWKPPEDDGGEPIEFYEIEKMNTKDGIWVPCGRSGDTHFTVDSLNKGDHYKFRVKAVNSEGPSDPLETETDILAKNP | ||||||
Repeat | 2793-2839 | Kelch 5 | ||||
Sequence: WKPPEDDGGEPIEFYEIEKMNTKDGIWVPCGRSGDTHFTVDSLNKGD | ||||||
Region | 2849-2901 | Disordered | ||||
Sequence: NSEGPSDPLETETDILAKNPFDRPDRPGRPEPTDWDSDHVDLKWDPPLSDGGA | ||||||
Compositional bias | 2864-2893 | Basic and acidic residues | ||||
Sequence: LAKNPFDRPDRPGRPEPTDWDSDHVDLKWD | ||||||
Domain | 2874-2968 | Fibronectin type-III 10 | ||||
Sequence: RPGRPEPTDWDSDHVDLKWDPPLSDGGAPIEEYQIEKRTKYGRWEPAITVPGGQTTATVPDLTPNEEYEFRVVAVNKGGPSDPSDASKAVIAKPR | ||||||
Domain | 2972-3062 | Ig-like 10 | ||||
Sequence: PHIDRDALKNLTIKAGQSISFDVPVSGEPAPTVTWHWPDNREIRNGGRVKLDNPEYQSKLVVKQMERGDSGTFTIKAVNANGEDEATVKIN | ||||||
Domain | 3070-3165 | Fibronectin type-III 11 | ||||
Sequence: PNGPLDVSDVHGDHVTLNWRAPDDDGGIPIENYVIEKYDTASGRWVPAAKVAGDKTTAVVDGLIPGHEYKFRVAAVNAEGESDPLETFGTTLAKDP | ||||||
Repeat | 3089-3134 | Kelch 6 | ||||
Sequence: RAPDDDGGIPIENYVIEKYDTASGRWVPAAKVAGDKTTAVVDGLIP | ||||||
Domain | 3171-3265 | Fibronectin type-III 12 | ||||
Sequence: KTNAPEITDWDKDHVDLEWKPPANDGGAPIEEYVVEMKDEFSPFWNDVAHVPAGQTNATVGNLKEGSKYEFRIRAKNKAGLGDPSDSASAVAKAR | ||||||
Domain | 3268-3358 | Ig-like 11 | ||||
Sequence: PPVIDRNSIQEIKVKAGQDFSLNIPVSGEPTPTITWTFEGTPVESDDRMKLNNEDGKTKFHVKRALRSDTGTYIIKAENENGTDTAEVKVT | ||||||
Domain | 3365-3459 | Fibronectin type-III 13 | ||||
Sequence: SPRGPLDVTNIVKDGCDLAWKEPEDDGGAEISHYVIEKQDAATGRWTACGESKDTNFHVDDLTQGHEYKFRVKAVNRHGDSDPLEAREAIIAKDP | ||||||
Repeat | 3384-3430 | Kelch 7 | ||||
Sequence: WKEPEDDGGAEISHYVIEKQDAATGRWTACGESKDTNFHVDDLTQGH | ||||||
Domain | 3465-3559 | Fibronectin type-III 14 | ||||
Sequence: KPGTPEIVDWDKDHADLKWTPPADDGGAPIEGYLVEMRTPSGDWVPAVTVGAGELTATVDGLKPGQTYQFRVKALNKAGESTPSDPSRTMVAKPR | ||||||
Domain | 3563-3653 | Ig-like 12 | ||||
Sequence: PKINRDMFVAQRVKAGQTLNFDVNVEGEPAPKIEWFLNGSPLSSGGNTHIDNNTDNNTKLTTKSTARADSGKYKIVATNESGKDEHEVDVN | ||||||
Domain | 3661-3753 | Fibronectin type-III 15 | ||||
Sequence: PEGPLRHKDITKESVVLKWDEPLDDGGSPITNYVVEKQEDGGRWVPCGETSDTSLKVNKLSEGHEYKFRVKAVNRQGTSAPLTSDHAIVAKNP | ||||||
Domain | 3759-3853 | Fibronectin type-III 16 | ||||
Sequence: APTDVTPVDWDKDHVDLEWKPPANDGGAPIDAYIVEKKDKFGDWVECARVDGKTTKATADNLTPGETYQFRVKAVNKAGPGKPSDPTGNVVAKPR | ||||||
Domain | 3954-4047 | Fibronectin type-III 17 | ||||
Sequence: PEGPLKIDEIHKEGCTLNWKPPTDNGGTDVLHYIVEKMDTSRGTWQEVGTFPDCTAKVNKLVPGKEYAFRVKAVNLQGESKPLEAEEPIIAKNQ | ||||||
Repeat | 3972-4018 | Kelch 8 | ||||
Sequence: WKPPTDNGGTDVLHYIVEKMDTSRGTWQEVGTFPDCTAKVNKLVPGK | ||||||
Domain | 4053-4146 | Fibronectin type-III 18 | ||||
Sequence: PVDKPEVTDWDKDRIDIKWNPTANNGGAPVTGYIVEKKEKGSAIWTEAGKTPGTTFSADNLKPGVEYEFRVIAVNAAGPSDPSDPTDPQITKAR | ||||||
Domain | 4246-4340 | Fibronectin type-III 19 | ||||
Sequence: PEGPLEVSDVTKDSCVLNWKPPKDDGGAEISNYVVEKRDTKTNTWVPVSAFVTGTSITVPKLTEGHEYEFRVMAENTFGRSDSLNTDEPVLAKDP | ||||||
Repeat | 4265-4310 | Kelch 9 | ||||
Sequence: KPPKDDGGAEISNYVVEKRDTKTNTWVPVSAFVTGTSITVPKLTEG | ||||||
Domain | 4346-4440 | Fibronectin type-III 20 | ||||
Sequence: KPGRPEIVDTDNDHIDIKWDPPRDNGGSPVDHYDIERKDAKTGRWIKVNTSPVQGTAFSDTRVQKGHTYEYRVVAVNKAGPGQPSDSSAAATAKP | ||||||
Repeat | 4365-4410 | Kelch 10 | ||||
Sequence: DPPRDNGGSPVDHYDIERKDAKTGRWIKVNTSPVQGTAFSDTRVQK | ||||||
Domain | 4445-4531 | Ig-like 13 | ||||
Sequence: PKFDLDLDGKEFRVKAGEPLVITIPFTASPQPDISWTKEGGKPLAGVETTDSQTKLVIPSTRRSDSGPVKIKAVNPYGEAEANIKIT | ||||||
Domain | 4538-4631 | Fibronectin type-III 21 | ||||
Sequence: APENITYPAVSRHTCTLNWDAPKDDGGAEIAGYKIEYQEVGSQIWDKVPGLISGTAYTVRGLEHGQQYRFRIRAENAVGLSDYCQGVPVVIKDP | ||||||
Repeat | 4557-4602 | Kelch 11 | ||||
Sequence: DAPKDDGGAEIAGYKIEYQEVGSQIWDKVPGLISGTAYTVRGLEHG | ||||||
Domain | 4637-4733 | Fibronectin type-III 22 | ||||
Sequence: APSTPEITGYDTNQVSLAWNPPRDDGGSPILGYVVERFEKRGGGDWAPVKMPMVKGTECIVPGLHENETYQFRVRAVNAAGHGEPSNGSEPVTCRPY | ||||||
Domain | 4739-4834 | Fibronectin type-III 23 | ||||
Sequence: APDAPRVGKITKNSAELTWNRPLRDGGAPIDGYIVEKKKLGDNDWTRCNDKPVRDTAFEVKNLGEKEEYEFRVIAVNSAGEGEPSKPSDLVLIEEQ | ||||||
Domain | 4936-5028 | Fibronectin type-III 24 | ||||
Sequence: PTGPIRATDIQADAMTLSWRPPKDNGGDAITNYVVEKRTPGGDWVTVGHPVGTTLRVRNLDANTPYEFRVRAENQYGVGEPLETDDAIVAKNP | ||||||
Domain | 5034-5129 | Fibronectin type-III 25 | ||||
Sequence: APGQPEAVETSEEAITLQWTRPTSDGGAPIQGYVIEKREVGSTEWTKAAFGNILDTKHRVTGLTPKKTYEFRVAAYNAAGQGEYSVNSVPITADNA | ||||||
Domain | 5231-5326 | Fibronectin type-III 26 | ||||
Sequence: SPQHIRVEDIAPDCCTLYWMPPSSDGGSPITNYIVEKLDLRHSDGKWEKVSSFVRNLNYTVGGLIKDNRYRFRVRAETQYGVSEPCELADVVVAKY | ||||||
Repeat | 5287-5335 | Kelch 12 | ||||
Sequence: LNYTVGGLIKDNRYRFRVRAETQYGVSEPCELADVVVAKYQFEVPNQPE | ||||||
Domain | 5333-5427 | Fibronectin type-III 27 | ||||
Sequence: QPEAPTVRDKDSTWAELEWDPPRDGGSKIIGYQVQYRDTSSGRWINAKMDLSEQCHARVTGLRQNGEFEFRIIAKNAAGFSKPSPPSERCQLKSR | ||||||
Domain | 5430-5528 | Fibronectin type-III 28 | ||||
Sequence: PPGPPIHVGAKSIGRNHCTITWMAPLEDGGSKITGYNVEIREYGSTLWTVASDYNVREPEFTVDKLREFNDYEFRVVAINAAGKGIPSLPSGPIKIQES | ||||||
Domain | 5533-5621 | Ig-like 14 | ||||
Sequence: PQIVVKPEDTAQPYNRRAVFTCEAVGRPEPTARWLRNGRELPESSRYRFEASDGVYKFTIKEVWDIDAGEYTVEVSNPYGSDTATANLV | ||||||
Domain | 5723-5817 | Fibronectin type-III 29 | ||||
Sequence: PQGPLHISNIGPSTATLSWRPPVTDGGSKITSYVVEKRDLSKDEWVTVTSNVKDMNYIVTGLFENHEYEFRVSAQNENGIGAPLVSEHPIIARLP | ||||||
Repeat | 5742-5787 | Kelch 13 | ||||
Sequence: RPPVTDGGSKITSYVVEKRDLSKDEWVTVTSNVKDMNYIVTGLFEN | ||||||
Domain | 5823-5919 | Fibronectin type-III 30 | ||||
Sequence: SPLNLEIVQVGGDYVTLSWQRPLSDGGGRLRGYIVEKQEEEHDEWFRCNQNPSPPNNYNVPNLIDGRKYRYRVFAVNDAGLSDLAELDQTLFQASGS | ||||||
Domain | 5923-6011 | Ig-like 15 | ||||
Sequence: PKIVSPLSDLNEEVGRCVTFECEISGSPRPEYRWFKGCKELVDTSKYTLINKGDKQVLIINDLTSDDADEYTCRATNSSGTRSTRANLR | ||||||
Domain | 6016-6107 | Ig-like 16 | ||||
Sequence: PRVFIPPKYHGGYEAQKGETIELKIPYKAYPQGEARWTKDGEKIENNSKFSITTDDKFATLRISNASREDYGEYRVVVENSVGSDSGTVNVT | ||||||
Domain | 6114-6207 | Fibronectin type-III 31 | ||||
Sequence: PPRFPIIENILDEAVILSWKPPALDGGSLVTNYTIEKREAMGGSWSPCAKSRYTYTTIEGLRAGKQYEFRIIAENKHGQSKPCEPTAPVLIPGD | ||||||
Domain | 6261-6516 | Protein kinase | ||||
Sequence: YDIHEELGTGAFGVVHRVTERATGNNFAAKFVMTPHESDKETVRKEIQTMSVLRHPTLVNLHDAFEDDNEMVMIYEFMSGGELFEKVADEHNKMSEDEAVEYMRQVCKGLCHMHENNYVHLDLKPENIMFTTKRSNELKLIDFGLTAHLDPKQSVKVTTGTAEFAAPEVAEGKPVGYYTDMWSVGVLSYILLSGLSPFGGENDDETLRNVKSCDWNMDDSAFSGISEDGKDFIRKLLLADPNTRMTIHQALEHPWL | ||||||
Region | 6517-6581 | C-terminal regulatory domain (CDR) | ||||
Sequence: TPGNAPGRDSQIPSSRYTKIRDSIKTKYDAWPEPLPPLGRISNYSSLRKHRPQEYSIRDAFWDRS | ||||||
Domain | 6585-6673 | Ig-like 17 | ||||
Sequence: PRFIVKPYGTEVGEGQSANFYCRVIASSPPVVTWHKDDRELKQSVKYMKRYNGNDYGLTINRVKGDDKGEYTVRAKNSYGTKEEIVFLN | ||||||
Domain | 6696-6795 | Ig-like 18 | ||||
Sequence: PRVEEFKERRSAPFFTFHLRNRLIQKNHQCKLTCSLQGNPNPTIEWMKDGHPVDEDRVQVSFRSGVCSLEIFNARVDDAGTYTVTATNDLGVDVSECVLT | ||||||
Domain | 6863-6952 | Ig-like 19 | ||||
Sequence: PSFTAQLSDSETEVGGSAEFSAAVSGQPEPLIEWLHNGERISESDSRFRASYVAGKATLRISDAKKSDEGQYLCRASNSAGQEQTRATLT | ||||||
Domain | 6958-7059 | Ig-like 20 | ||||
Sequence: PLLNGHAGQAVESELRVTKHLGGEIVNNGESVTFEARVQGTPEEVLWMRNGQELTNGDKTSISQDGETLSFTINSADASDAGHYQLEVRSKGTNLVSVASLV | ||||||
Domain | 7067-7149 | Ig-like 21 | ||||
Sequence: PPVTRLPSSVSAPLGGSTAFTIEFENVEGLTVQWFRGSEKIEKNERVKSVKTGNTFKLDIKNVEQDDDGIYVAKVVKEKKAIA |
Sequence similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 5 isoforms produced by Alternative splicing.
Q23551-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Nameb
- Length7,158
- Mass (Da)788,953
- Last updated2003-06-01 v3
- Checksum561EF9DB13387505
Q23551-2
- Namea
Q23551-3
- Namec
Q23551-4
- Named
- Differences from canonical
- 551-809: ESQLDEIPSSGLTIPEERRRELLGQVGESDDEVSESISELPSFAGGKPRRKTDSPPKQDDMFSRDTLLRKTTTSTKNESSTVEEKTKLRKTVKKVDGELDFKAMVKLKKVKKEEGGTTEKSGFPLDHADSTSSVLSQESRSRRGSNAPFAKDGLPEQPANPFAQLKKVKSGAGGLEKSDSMASLKKLDLKKGKIDDNSDGAFKVQLKKVVKKEVKESTISVKEKNGTESGIKTEFKMEKRERTTLQKYEKTDSDGSKKE → NLLKKSASNDGSDHGASPSSSTSSSSRRLPPRPPLESSHSASSPSSSNGGPRRMFNLRSASDRQGASRPTGGQTPNPLNMRSANSSGQDLHKISQIHAFILSKMPEGEAKERFLRSILDLEGPDSRRGSRDDVGSPNMLKKTNSKSSVNSSSNESQLDEIPSSGLTIPEERRRELLGQVGESDDEVSESISELPSFAGGKPRRKTD
- 835-947: Missing
Q23551-5
- Namee
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
H2FLH2 | H2FLH2_CAEEL | unc-22 | 6927 | ||
H2FLH3 | H2FLH3_CAEEL | unc-22 | 6848 | ||
A0A061AE24 | A0A061AE24_CAEEL | unc-22 | 7142 | ||
A0A061ACT3 | A0A061ACT3_CAEEL | unc-22 | 7133 |
Sequence caution
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_040606 | 1-539 | in isoform c | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_040605 | 1-610 | in isoform e | |||
Sequence: Missing | ||||||
Compositional bias | 208-222 | Basic and acidic residues | ||||
Sequence: PDPSERQERKRSTAS | ||||||
Compositional bias | 223-237 | Polar residues | ||||
Sequence: PRPSSRGPGSRPSSP | ||||||
Compositional bias | 238-262 | Basic and acidic residues | ||||
Sequence: KKSMKSREGTPKRTLKPREGSPSKK | ||||||
Compositional bias | 263-277 | Polar residues | ||||
Sequence: LRSRTSTPVNEEVSQ | ||||||
Compositional bias | 278-297 | Basic and acidic residues | ||||
Sequence: SESRRSSRTDKMEVDQVSGA | ||||||
Compositional bias | 320-371 | Polar residues | ||||
Sequence: PSTRKSPSRKSASPTPSRKGSSAGGAASGTTGASASATSATSGGSASSDASR | ||||||
Compositional bias | 473-504 | Basic and acidic residues | ||||
Sequence: EEELMKHRKDAEDEYQKEEQKSQTLQAETKKR | ||||||
Compositional bias | 516-530 | Polar residues | ||||
Sequence: PAPQAKKSTTSESGR | ||||||
Compositional bias | 531-552 | Basic and acidic residues | ||||
Sequence: QEASEVEHKRSSSVRPDPDEES | ||||||
Alternative sequence | VSP_040607 | 540-550 | in isoform c | |||
Sequence: RSSSVRPDPDE → MGQDFDSDSDS | ||||||
Alternative sequence | VSP_040608 | 551-809 | in isoform d | |||
Sequence: ESQLDEIPSSGLTIPEERRRELLGQVGESDDEVSESISELPSFAGGKPRRKTDSPPKQDDMFSRDTLLRKTTTSTKNESSTVEEKTKLRKTVKKVDGELDFKAMVKLKKVKKEEGGTTEKSGFPLDHADSTSSVLSQESRSRRGSNAPFAKDGLPEQPANPFAQLKKVKSGAGGLEKSDSMASLKKLDLKKGKIDDNSDGAFKVQLKKVVKKEVKESTISVKEKNGTESGIKTEFKMEKRERTTLQKYEKTDSDGSKKE → NLLKKSASNDGSDHGASPSSSTSSSSRRLPPRPPLESSHSASSPSSSNGGPRRMFNLRSASDRQGASRPTGGQTPNPLNMRSANSSGQDLHKISQIHAFILSKMPEGEAKERFLRSILDLEGPDSRRGSRDDVGSPNMLKKTNSKSSVNSSSNESQLDEIPSSGLTIPEERRRELLGQVGESDDEVSESISELPSFAGGKPRRKTD | ||||||
Compositional bias | 562-577 | Basic and acidic residues | ||||
Sequence: LTIPEERRRELLGQVG | ||||||
Compositional bias | 600-616 | Basic and acidic residues | ||||
Sequence: RKTDSPPKQDDMFSRDT | ||||||
Alternative sequence | VSP_040609 | 604-809 | in isoform a | |||
Sequence: Missing | ||||||
Compositional bias | 674-694 | Polar residues | ||||
Sequence: PLDHADSTSSVLSQESRSRRG | ||||||
Compositional bias | 763-815 | Basic and acidic residues | ||||
Sequence: EVKESTISVKEKNGTESGIKTEFKMEKRERTTLQKYEKTDSDGSKKEDKPKKV | ||||||
Compositional bias | 828-849 | Basic and acidic residues | ||||
Sequence: DEPSTPRHHKEVEEKSTSEELK | ||||||
Alternative sequence | VSP_040611 | 835-947 | in isoform a, isoform d and isoform e | |||
Sequence: Missing | ||||||
Compositional bias | 881-955 | Basic and acidic residues | ||||
Sequence: KVTKKAHDDTNELEGIKLKKVTTVPKHVADDDSQSESESRRGSVFGELRRGSRAPRDSADNSRRDSIRRSSIDMR | ||||||
Compositional bias | 2269-2283 | Basic and acidic residues | ||||
Sequence: DALSTDKDTKAKNPY | ||||||
Compositional bias | 2864-2893 | Basic and acidic residues | ||||
Sequence: LAKNPFDRPDRPGRPEPTDWDSDHVDLKWD |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X15423 EMBL· GenBank· DDBJ | CAA33463.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
Z73897 EMBL· GenBank· DDBJ | CAA98064.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z73899 EMBL· GenBank· DDBJ | CAA98064.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z73897 EMBL· GenBank· DDBJ | CAA98065.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z73899 EMBL· GenBank· DDBJ | CAA98065.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z73897 EMBL· GenBank· DDBJ | CAM35838.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z73899 EMBL· GenBank· DDBJ | CAM35838.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z73897 EMBL· GenBank· DDBJ | CBK19522.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z73899 EMBL· GenBank· DDBJ | CBK19522.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z73897 EMBL· GenBank· DDBJ | CBK19523.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z73899 EMBL· GenBank· DDBJ | CBK19523.1 EMBL· GenBank· DDBJ | Genomic DNA |