Q23049 · TTC8_CAEEL

  • Protein
    Tetratricopeptide repeat protein 8
  • Gene
    bbs-8
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Component of the BBSome complex (By similarity).
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity).
The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function (By similarity).
Required for proper BBSome complex assembly and its ciliary localization (PubMed:22922713).
Required for cilia biogenesis and both the assembly and movement of intraflagellar transport proteins along the ciliary axoneme (PubMed:15231740, PubMed:17000880, PubMed:22022287, PubMed:22922713, PubMed:27930654).
Plays a role in guanylyl cyclase localization in the ring-like structures at the base of the finger compartment in AFD sensory neurons (PubMed:25335890).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentBBSome
Cellular Componentciliary basal body
Cellular Componentciliary base
Cellular Componentcilium
Cellular Componentcytoplasm
Cellular Componentdendrite terminus
Cellular Componentneuron projection
Cellular Componentnon-motile cilium
Biological Processchemotaxis
Biological Processcilium assembly
Biological Processintraciliary transport
Biological Processnon-motile cilium assembly
Biological Processolfactory learning
Biological Processpositive regulation of intraciliary anterograde transport
Biological Processpositive regulation of intraciliary retrograde transport
Biological Processpositive regulation of protein localization to ciliary membrane
Biological Processprotein localization to microvillus membrane
Biological Processprotein transport

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Tetratricopeptide repeat protein 8
  • Alternative names
    • Bardet-Biedl syndrome 8 protein homolog

Gene names

    • Name
      bbs-8
    • ORF names
      T25F10.5

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    Q23049

Proteomes

Organism-specific databases

Subcellular Location

Note: Localized at the ciliary base and also in ring-like structures between the base of the AFD sensory neuron finger compartment and the dendritic membrane.

Keywords

Phenotypes & Variants

Disruption phenotype

Mutants have normal body morphology, but with reduced body length and width, delayed larval development and decreased roaming movements (PubMed:22022287).
May exhibit defective chemotaxis tendencies (PubMed:15231740).
Defective sensory cilia structure and function (PubMed:15231740, PubMed:22022287).
This is characterized by increased accumulation and mislocalization of intraflagellar transport proteins and impaired movement of intraflagellar transport proteins such as rab-28 along the ciliary axoneme (PubMed:15231740, PubMed:27930654).
Disrupted assembly of the BBSome complex at the base of the cilia (PubMed:22922713).
Impaired localization of the guanylyl cyclase proteins, gcy-8, gcy-18 and gcy-23, within AFD sensory neurons, with accumulation along the dendrite as well as in the finger compartment of AFD neurons (PubMed:25335890).
Thermotaxis defects and impaired tendencies to migrate to a food source (PubMed:25335890).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004350011-506Tetratricopeptide repeat protein 8

Proteomic databases

Expression

Tissue specificity

Expressed in head and tail neurons (PubMed:15231740).
Expressed in ciliated male tail-neurons (PubMed:14520415).
Expressed in thermosensory and CO2 sensory AFD neurons (PubMed:25335890).

Developmental stage

Expressed from the embryonic stage to adulthood. Expressed in embryos from the 1.5-fold stage, with expression increasing to the 3-fold stage. Expressed in ciliated cells including amphid and both inner and outer labial neurons of the head at larval stages L1 and L2. Expressed in both phasmid neurons PHA and PHB in the tail and in the PDE sensory neuron in the mid-body at larval stage L3 and L4.

Gene expression databases

    • WBGene00000244Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues

Interaction

Subunit

Part of BBSome complex, that contains at least bbs-1, bbs-2, bbs-4, bbs-5, osm-12, bbs-8/ttc-8 and bbs-9.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, repeat.

TypeIDPosition(s)Description
Region83-112Disordered
Repeat217-250TPR 1
Repeat251-283TPR 2
Repeat284-317TPR 3
Repeat319-351TPR 4
Repeat353-385TPR 5
Repeat388-421TPR 6
Repeat423-455TPR 7
Repeat456-489TPR 8

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    506
  • Mass (Da)
    56,304
  • Last updated
    2002-10-01 v2
  • Checksum
    E72170400424F53B
MSGESVIEFTGFIKACRLFRENRLAEAEAVCTNLLRKNPLDQATWALKMQCLSDSTYVDELENEDMGLAETFLDQNVIAPNARPGTSFARPKTSAKGVNPILRPTTNAGRPLSGVVRPQSSFKSGSMDQAVRTARTAKTARAVSSTSARNMRLGTASMAAGADGEFVNLARLNIDKYAADPQVNRQLFEYVFYYLNDIRVAHQIAGTASKAAGFEDYYWKNQLAKCYLRLGMLQDATKQLQSSLEQKKLIETFALLSKAYNRVDQPMAALKTYSAGLEVFPENVTMLTGMARVQEALGEYDESVKLYKRVLDAESNNIEAIACVATTYYYGGKPELAMRYYRRILQMGVSSPELFLNIGLCCMAAQQFDFALSSILRAQSTMTDDVAADVWYNIGQILVDIGDLVSAARSFRIALSHDPDHSESLVNLGILKHREGKIDEARSLYSSATSKNPYMFEGNYNLGLVSFTQGKYHECRELIEKALAAFPEHEHCKKILNHLKPLYESI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX284605
EMBL· GenBank· DDBJ
CCD74239.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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