Q22592 · BECN_CAEEL

Function

function

Regulates autophagy (PubMed:12958363).
Together with phosphatidyl-3-phosphate kinase vps-34, acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate (PtdIns3P), thereby regulating membrane trafficking (PubMed:16111945, PubMed:21183797, PubMed:26783301).
In association with sorf-1 and sorf-2, negatively regulates phosphatidylinositol 3-phosphate in early endosomes to allow for the conversion to late endosomes (PubMed:26783301).
Involved in the clearance of engulfed apoptotic cell corpses (PubMed:16111945, PubMed:21183797).
Together with ced-9, negatively regulates somatic and germline apoptosis (PubMed:17890369).
Plays a role in endosome-to-Golgi retrograde transport of mig-14 (PubMed:21183797).
In a daf-18/PTEN- and skn-1/Nrf-dependent manner, promotes germline stem cell proliferation during late and adult stages, probably by ensuring cell survival and cell cycle progression (PubMed:28285998).
Required for embryonic development and L3/L4 molting during larval development (PubMed:16111945).
Required for normal dauer morphogenesis and lifespan (PubMed:12958363, PubMed:17204841).
Plays a role in male tail ray pattern formation (PubMed:17890369).
Required for normal survival when exposed to pathogenic bacteria S.typhimurium by promoting autophagic degradation of intracellular S.typhimurium (PubMed:19667176).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxon
Cellular Componentcytoplasm
Cellular Componentcytoplasmic vesicle
Cellular Componentdendrite
Cellular Componentendosome
Cellular Componentnucleus
Cellular Componentperikaryon
Cellular Componentphagophore assembly site
Cellular Componentphosphatidylinositol 3-kinase complex, class III, type I
Cellular Componentphosphatidylinositol 3-kinase complex, class III, type II
Molecular Functionphosphatidylinositol 3-kinase binding
Molecular Functionprotein-macromolecule adaptor activity
Biological Processapoptotic cell clearance
Biological Processautophagosome assembly
Biological Processautophagy
Biological Processcellular response to nitrogen starvation
Biological Processcellular response to starvation
Biological Processdauer larval development
Biological Processdetermination of adult lifespan
Biological Processgerm cell proliferation
Biological Processgerm-line stem cell division
Biological Processlate endosome to vacuole transport
Biological Processmitophagy
Biological Processnematode male tail tip morphogenesis
Biological Processorganelle fusion
Biological Processpositive regulation of early endosome to late endosome transport
Biological Processprogrammed cell death
Biological Processprotein catabolic process
Biological Processregulation of endosome size
Biological Processregulation of multicellular organism growth

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Beclin homolog

Gene names

    • Name
      bec-1
    • Synonyms
      atg-6
    • ORF names
      T19E7.3

Organism names

  • Taxonomic identifier
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    Q22592
  • Secondary accessions
    • V6CL88

Proteomes

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Disruption phenotype

Embryonic lethal with few surviving larvae which fail to carry out the L3/L4 molt and few surviving adults which are sterile (PubMed:16111945, PubMed:21183797).
At the L3 larval stage, accumulates vacuoles in intestine, hypodermis, pharynx and coelomocytes (PubMed:21183797).
Abnormal accumulation of mig-14, lmp-1, and rab-7 on these vacuoles (PubMed:21183797).
Mislocalization of several components of the retromer complex, including rme-8, snx-1 and vps-35 (PubMed:21183797).
Impaired fluid phase endocytosis in coelomocytes (PubMed:21183797).
Double knockout with either sorf-1 or sorf-2 results in smaller endosomes and an irregular distribution pattern of PtdIns3P in the cytoplasm (PubMed:26783301).
RNAi-mediated knockdown results in reduced stem cell proliferation in the germline during larval development (PubMed:28285998).
RNAi-mediated knockdown at the L4 larval stage causes a slight decrease in lifespan and multiple defects in the progeny which fails to produce viable embryos (PubMed:12958363, PubMed:16111945, PubMed:17204841).
In addition, causes an increase in the number of apoptotic cell corpses at various embryonic stages and in the gonads (PubMed:16111945, PubMed:21183797).
Reduces phosphatidylinositol 3-phosphate levels on intracellular membrane vesicles and impairs endocytosis (PubMed:16111945, PubMed:21183797).
Prevents necrotic cell death of CEP and ADE dopamine neurons induced by neurotoxin 6-hydroxidopamine (PubMed:17327275).
Impaired survival when exposed to pathogenic bacteria S.typhimurium which is associated with the persistence of intact bacteria-containing vesicles in intestinal cells, the formation of few autophagosomes and autolysosomes followed by a progressive destruction of intestinal cells (PubMed:19667176).
In addition, causes a reduction in mig-14 and rme-8 association with puncta structures as well as an increase in mig-14 protein levels (PubMed:21183797).
RNAi-mediated knockdown causes abnormalities in constitutive dauer formation in daf-2 e1370 mutant including uneven distribution of hyperpigmented granules in the intestine and a reduction in fat storage and radial constriction elongation of the body and the pharynx (PubMed:12958363).
In addition, prevents increase in lifespan and the formation of autophagosomes in lateral hypodermal seam cells in daf-2 e1370 mutant (PubMed:12958363, PubMed:19667176).
Reduces the number of vacuolated (dying) touch receptor neurons and restores touch sensitivity in mec-4 u231, deg-1 u506 or deg-3 u662 mutants (PubMed:17327275).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004363041-375Beclin homolog

Proteomic databases

Expression

Tissue specificity

Expressed in PVM touch receptor neurons, the ventral nerve cord and in the nerve ring.

Developmental stage

Highly expressed in embryos and to a lesser extent in larvae (PubMed:16111945).
Expressed in pharynx, seam cells and ventral nerve cord neurons at the L1 and L4 larval stages (PubMed:12958363, PubMed:16111945).
Expressed in vulva cell precursors and somatic gonad at the L2 larval stage and in vulva at the L4 larval stage (PubMed:12958363).

Gene expression databases

Interaction

Subunit

Interacts with ced-9 (PubMed:16111945).
Interacts with vps-34 (PubMed:16111945, PubMed:26783301).
Interacts with sorf-1 and sorf-2 (PubMed:26783301).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q22592sorf-1 Q235333EBI-2413500, EBI-13941886
BINARY Q22592sorf-2 Q101223EBI-2413500, EBI-13941960
BINARY Q22592vps-34 Q9TXI72EBI-2413500, EBI-21398789

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for coiled coil.

TypeIDPosition(s)Description
Coiled coil71-147

Sequence similarities

Belongs to the beclin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q22592-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    375
  • Mass (Da)
    42,774
  • Last updated
    2001-10-01 v2
  • Checksum
    630D0F04EEF324D8
MTTQRSHICLNCQHPLRLDFTQRRPDSADSEKKSETVITEALTGHSRNLMKLISDAQFPSDAPVCNDCSDALRNEMDAQVATLDDEIKTYQTYINYLKENHPTTSIPDLKAKLQNVSDEEKELEQQLKKLLAEEEQLDLDLQTKRRTAEAASEKSGELWKKYRDNLRQVFEDQDELHSLEAERQYAEVQHRKLTDTNVLDLCFHIWVDGIVGEINGFRLGYLKDAPVEFTEINAALGQIVLLLEILLERIGVQHHELMPVAMGSHSYIKLRRNGIDMETYALYGQGTPLSGSSGIDPGIRRFLQLLEFLLKELKDRNKNFKPPYQIHADSLVDNGVKYNAVMTLNTDVRWTRAMALMLTDLKAACAQCDALRSPI

Q22592-2

  • Name
    b
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0583421-257in isoform b

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX284604
EMBL· GenBank· DDBJ
CCD62215.1
EMBL· GenBank· DDBJ
Genomic DNA
BX284604
EMBL· GenBank· DDBJ
CDK13324.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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