Q22328 · LEV9_CAEEL

Function

function

Scaffolding protein that is necessary to cluster acetylcholine receptors at neuromuscular junctions.

Features

Showing features for site.

162250100150200250300350400450500550600
TypeIDPosition(s)Description
Site575-576Cleavage

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Cellular Componentsynapse
Molecular Functionpeptidase inhibitor activity

Names & Taxonomy

Protein names

  • Recommended name
    Protein lev-9

Gene names

    • Name
      lev-9
    • ORF names
      T07H6.5

Organism names

  • Taxonomic identifier
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    Q22328
  • Secondary accessions
    • C7C692

Proteomes

Organism-specific databases

Subcellular Location

Synapse
Secreted
Note: Secreted by muscle cells and localizes at cholinergic neuromuscular junctions.

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation, propeptide.

TypeIDPosition(s)Description
Signal1-16
ChainPRO_000043031317-575Protein lev-9
Disulfide bond19↔49
Disulfide bond35↔47
Disulfide bond41↔57
Disulfide bond64↔105
Disulfide bond91↔118
Disulfide bond124↔171
Disulfide bond154↔188
Disulfide bond193↔233
Disulfide bond219↔246
Disulfide bond251↔291
Disulfide bond277↔304
Disulfide bond309↔349
Disulfide bond335↔362
Disulfide bond366↔409
Disulfide bond395↔420
Glycosylation411N-linked (GlcNAc...) asparagine
Disulfide bond425↔467
Disulfide bond452↔481
Disulfide bond486↔543
Disulfide bond529↔556
PropeptidePRO_0000430314576-622

Post-translational modification

Proteolytic processing of the C-terminus is required for clustering activity but not for secretion nor traffic.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain17-61WAP; atypical
Domain62-120Sushi 1
Domain122-190Sushi 2
Domain191-248Sushi 3
Domain249-306Sushi 4
Domain307-364Sushi 5
Domain365-422Sushi 6
Domain423-483Sushi 7
Domain484-558Sushi 8

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    622
  • Mass (Da)
    68,692
  • Last updated
    2013-02-06 v3
  • Checksum
    60965F9799A0D5DC
MRFLLLLAISITYASALSCPEVTLSQRPKHCKKECIADEDCKRNKRCMCDGECGLSCVNPIAMCHPLPNIENGFIRTAGDLRFGSNAEYGCNKGYILVGASQRRCQANKEWSSSQPVCRLQLKCGPPPEIPFAVHDGSSFSGEYDLDAEVAYNCIPGYHKFNAKGLSISKCLLNRKNVAQWFGPDLRCKARACPDPGDIENGLREGDTFEYPHHVKYSCNPGFLLVGSTSRQCSSNGEWTNEPANCKATECSRPSSPLHGKVVGSSLTYQSVVTYSCDHGYRLVGQVQRICLAEGIWGGNEPRCEEIRCSVLPTLPNGYIEGSETSFGAVAVFRCLETMTHEGASKAKCMEDGQWSAPIPRCLASCRVPHIQNGKIRDKSEGQLIASGSKVIVECNKQHEANIDERLICSNSTWSHVPVCSPLSCHNWPPRVPHARILFSKSSHGSIAKYECNNGYHPNRNNQIIKCLYGEWTKDGPPMKCLPSWCEHPSKTYGTLPGGQILLEGILGAYEFQSYIQKVEEGRAISFQCGKGNYLIGPPKATCVNGEWMPKVSPKCVSQTHPMIEGKILWDRKKRSLPGRAVREYVDDELSTHRQHSGKCGIVSGKLERMIMQHSDNGVSVC

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1N7SZ15A0A1N7SZ15_CAEELlev-9626
A0A1N7SYU8A0A1N7SYU8_CAEELlev-91347

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FN433774
EMBL· GenBank· DDBJ
CBA12962.1
EMBL· GenBank· DDBJ
mRNA
FO081717
EMBL· GenBank· DDBJ
CCD74396.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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