Q22328 · LEV9_CAEEL
- ProteinProtein lev-9
- Genelev-9
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids622 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Scaffolding protein that is necessary to cluster acetylcholine receptors at neuromuscular junctions.
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 575-576 | Cleavage | ||||
Sequence: RS |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Cellular Component | synapse | |
Molecular Function | peptidase inhibitor activity |
Names & Taxonomy
Protein names
- Recommended nameProtein lev-9
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ22328
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation, propeptide.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-16 | |||||
Sequence: MRFLLLLAISITYASA | ||||||
Chain | PRO_0000430313 | 17-575 | Protein lev-9 | |||
Sequence: LSCPEVTLSQRPKHCKKECIADEDCKRNKRCMCDGECGLSCVNPIAMCHPLPNIENGFIRTAGDLRFGSNAEYGCNKGYILVGASQRRCQANKEWSSSQPVCRLQLKCGPPPEIPFAVHDGSSFSGEYDLDAEVAYNCIPGYHKFNAKGLSISKCLLNRKNVAQWFGPDLRCKARACPDPGDIENGLREGDTFEYPHHVKYSCNPGFLLVGSTSRQCSSNGEWTNEPANCKATECSRPSSPLHGKVVGSSLTYQSVVTYSCDHGYRLVGQVQRICLAEGIWGGNEPRCEEIRCSVLPTLPNGYIEGSETSFGAVAVFRCLETMTHEGASKAKCMEDGQWSAPIPRCLASCRVPHIQNGKIRDKSEGQLIASGSKVIVECNKQHEANIDERLICSNSTWSHVPVCSPLSCHNWPPRVPHARILFSKSSHGSIAKYECNNGYHPNRNNQIIKCLYGEWTKDGPPMKCLPSWCEHPSKTYGTLPGGQILLEGILGAYEFQSYIQKVEEGRAISFQCGKGNYLIGPPKATCVNGEWMPKVSPKCVSQTHPMIEGKILWDRKKR | ||||||
Disulfide bond | 19↔49 | |||||
Sequence: CPEVTLSQRPKHCKKECIADEDCKRNKRCMC | ||||||
Disulfide bond | 35↔47 | |||||
Sequence: CIADEDCKRNKRC | ||||||
Disulfide bond | 41↔57 | |||||
Sequence: CKRNKRCMCDGECGLSC | ||||||
Disulfide bond | 64↔105 | |||||
Sequence: CHPLPNIENGFIRTAGDLRFGSNAEYGCNKGYILVGASQRRC | ||||||
Disulfide bond | 91↔118 | |||||
Sequence: CNKGYILVGASQRRCQANKEWSSSQPVC | ||||||
Disulfide bond | 124↔171 | |||||
Sequence: CGPPPEIPFAVHDGSSFSGEYDLDAEVAYNCIPGYHKFNAKGLSISKC | ||||||
Disulfide bond | 154↔188 | |||||
Sequence: CIPGYHKFNAKGLSISKCLLNRKNVAQWFGPDLRC | ||||||
Disulfide bond | 193↔233 | |||||
Sequence: CPDPGDIENGLREGDTFEYPHHVKYSCNPGFLLVGSTSRQC | ||||||
Disulfide bond | 219↔246 | |||||
Sequence: CNPGFLLVGSTSRQCSSNGEWTNEPANC | ||||||
Disulfide bond | 251↔291 | |||||
Sequence: CSRPSSPLHGKVVGSSLTYQSVVTYSCDHGYRLVGQVQRIC | ||||||
Disulfide bond | 277↔304 | |||||
Sequence: CDHGYRLVGQVQRICLAEGIWGGNEPRC | ||||||
Disulfide bond | 309↔349 | |||||
Sequence: CSVLPTLPNGYIEGSETSFGAVAVFRCLETMTHEGASKAKC | ||||||
Disulfide bond | 335↔362 | |||||
Sequence: CLETMTHEGASKAKCMEDGQWSAPIPRC | ||||||
Disulfide bond | 366↔409 | |||||
Sequence: CRVPHIQNGKIRDKSEGQLIASGSKVIVECNKQHEANIDERLIC | ||||||
Disulfide bond | 395↔420 | |||||
Sequence: CNKQHEANIDERLICSNSTWSHVPVC | ||||||
Glycosylation | 411 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 425↔467 | |||||
Sequence: CHNWPPRVPHARILFSKSSHGSIAKYECNNGYHPNRNNQIIKC | ||||||
Disulfide bond | 452↔481 | |||||
Sequence: CNNGYHPNRNNQIIKCLYGEWTKDGPPMKC | ||||||
Disulfide bond | 486↔543 | |||||
Sequence: CEHPSKTYGTLPGGQILLEGILGAYEFQSYIQKVEEGRAISFQCGKGNYLIGPPKATC | ||||||
Disulfide bond | 529↔556 | |||||
Sequence: CGKGNYLIGPPKATCVNGEWMPKVSPKC | ||||||
Propeptide | PRO_0000430314 | 576-622 | ||||
Sequence: SLPGRAVREYVDDELSTHRQHSGKCGIVSGKLERMIMQHSDNGVSVC |
Post-translational modification
Proteolytic processing of the C-terminus is required for clustering activity but not for secretion nor traffic.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 17-61 | WAP; atypical | ||||
Sequence: LSCPEVTLSQRPKHCKKECIADEDCKRNKRCMCDGECGLSCVNPI | ||||||
Domain | 62-120 | Sushi 1 | ||||
Sequence: AMCHPLPNIENGFIRTAGDLRFGSNAEYGCNKGYILVGASQRRCQANKEWSSSQPVCRL | ||||||
Domain | 122-190 | Sushi 2 | ||||
Sequence: LKCGPPPEIPFAVHDGSSFSGEYDLDAEVAYNCIPGYHKFNAKGLSISKCLLNRKNVAQWFGPDLRCKA | ||||||
Domain | 191-248 | Sushi 3 | ||||
Sequence: RACPDPGDIENGLREGDTFEYPHHVKYSCNPGFLLVGSTSRQCSSNGEWTNEPANCKA | ||||||
Domain | 249-306 | Sushi 4 | ||||
Sequence: TECSRPSSPLHGKVVGSSLTYQSVVTYSCDHGYRLVGQVQRICLAEGIWGGNEPRCEE | ||||||
Domain | 307-364 | Sushi 5 | ||||
Sequence: IRCSVLPTLPNGYIEGSETSFGAVAVFRCLETMTHEGASKAKCMEDGQWSAPIPRCLA | ||||||
Domain | 365-422 | Sushi 6 | ||||
Sequence: SCRVPHIQNGKIRDKSEGQLIASGSKVIVECNKQHEANIDERLICSNSTWSHVPVCSP | ||||||
Domain | 423-483 | Sushi 7 | ||||
Sequence: LSCHNWPPRVPHARILFSKSSHGSIAKYECNNGYHPNRNNQIIKCLYGEWTKDGPPMKCLP | ||||||
Domain | 484-558 | Sushi 8 | ||||
Sequence: SWCEHPSKTYGTLPGGQILLEGILGAYEFQSYIQKVEEGRAISFQCGKGNYLIGPPKATCVNGEWMPKVSPKCVS |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length622
- Mass (Da)68,692
- Last updated2013-02-06 v3
- Checksum60965F9799A0D5DC
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1N7SZ15 | A0A1N7SZ15_CAEEL | lev-9 | 626 | ||
A0A1N7SYU8 | A0A1N7SYU8_CAEEL | lev-9 | 1347 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FN433774 EMBL· GenBank· DDBJ | CBA12962.1 EMBL· GenBank· DDBJ | mRNA | ||
FO081717 EMBL· GenBank· DDBJ | CCD74396.2 EMBL· GenBank· DDBJ | Genomic DNA |