Q21M18 · FABA_SACD2

Function

function

Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-2-decenoyl-ACP and then its isomerization to Z-3-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.

Catalytic activity

Pathway

Lipid metabolism; fatty acid biosynthesis.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site73

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
Molecular Functiontrans-2-decenoyl-acyl-carrier-protein isomerase activity
Biological Processunsaturated fatty acid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase
  • EC number
  • Alternative names
    • 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA
    • Beta-hydroxydecanoyl thioester dehydrase
    • Trans-2-decenoyl-[acyl-carrier-protein] isomerase
      (EC:5.3.3.14
      ) . EC:5.3.3.14 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      fabA
    • Ordered locus names
      Sde_0999

Organism names

Accessions

  • Primary accession
    Q21M18

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002677481-1743-hydroxydecanoyl-[acyl-carrier-protein] dehydratase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the thioester dehydratase family. FabA subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    174
  • Mass (Da)
    19,103
  • Last updated
    2006-04-18 v1
  • MD5 Checksum
    8235D586A97B9674AC74D04BE573F9FC
MQAFEQKSSYERAELITCGQGNMFGPGNAQLPVPNMLMLDRISHISQTGGEFGKGEIIAELDITPDLWFFDCHFPGDPVMPGCLGLDAMWQLVGFFLAWKGNAGRGRALGAGEVKFTGQILPTASKVTYHINLKRVIERKLVMGIADGRVAVDGKEIYFAKDLRVGLFTNTDSF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000282
EMBL· GenBank· DDBJ
ABD80261.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help