Q21770 · WAGO1_CAEEL
- ProteinArgonaute protein wago-1
- Genewago-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids945 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Argonaute protein which is involved in the endogenous small interfering RNA (endo-siRNA) pathway. Interacts with secondary 22G-RNAs, which are RNA-dependent RNA polymerase-derived endo-siRNAs, typically 22 nucleotides in length with a 5'guanosine residue. In the germline, functions in a genome surveillance system to silence transposons and aberrant transcripts.
Miscellaneous
Members of the WAGO (worm-specific argonaute) subfamily lack conserved metal-binding residues found in other argonaute proteins and probably do not cleave target mRNAs directly.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytoplasmic ribonucleoprotein granule | |
Cellular Component | nucleus | |
Cellular Component | P granule | |
Cellular Component | RISC complex | |
Molecular Function | DEAD/H-box RNA helicase binding | |
Molecular Function | RNA endonuclease activity | |
Molecular Function | single-stranded RNA binding | |
Biological Process | regulatory ncRNA-mediated post-transcriptional gene silencing |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameArgonaute protein wago-1
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ21770
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000087436 | 1-945 | Argonaute protein wago-1 | |||
Sequence: MSPHPPQPHPPMPPMPPVTAPPGAMTPMPPVPADAQKLHQSTGNDACIKRLQQLNVEDGAKMYMKPTEPGKMGRPVDIQTNVFGIEVTKETTVHRFMVHAKADLTSTKEVTFTKKGKEDFVVQDRRDKCCNIFFLAVEKNPEFFKMKDGNQIVYDGQSTLYTTVNLFSELDANGTKSKVFQINGADTGNDDLKTLPCISLEIYAPRDNSITLSSENLGKRTADQNIEVNNREYTQFLELALNQHCVRETNRFGCFEHGKVYFLNATEEGFDQRDCVDVGDGKQLYPGLKKTIQFIEGPYGRGQNNPSLVIDGMKAAFHKEQTVIQKLFDITGQDPSNGLNNMTREKAAAVIKGLDCYSTYTNRKRHLRIEGIFHESATKTRFELPDGKTCSIAEYYADKYKISLQYPNANLVVCKDRGNNNYFPAELMTVSRNQRVTIPQQTGNQSQKTTKECAVLPDVRQRMIITGKNAVNITLENELLVALGIKVYSEPLMVQARELDGKELVYQRSVMSDMGKWRAPPGWFVKPATVPDLWAAYAVGNPGCRFSIGDVNQLVGMFIDSCKKKGMVIKPPCETGLYSTEKIMTQLEKVAASKCKYVLMITDDAIVHLHKQYKALEQRTMMIVQDMKISKANAVVKDGKRLTLENIINKTNVKLGGLNYTVSDAKKSMTDEQLIIGVGVSAPPAGTKYMMDNKGHLNPQIIGFASNAVANHEFVGDFVLAPSGQDTMASIEDVLQNSIDLFEKNRKALPKRIIIYRSGASEGSHASILAYEIPLARAIIHGYSKEIKLIFIVVTKEHSYRFFRDQLRSGGKATEMNIPPGIVLDNAVTNPACKQFFLNGHTTLQGTAKTPLYTVLADDCKAPMDRLEELTFTLCHHHQIVSLSTSIPTPLYVANEYAKRGRDLWGELTTKGPIEAKESQGERLKELTKEIGYKQTDLNQKRVNA |
Proteomic databases
Expression
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-29 | Pro residues | ||||
Sequence: MSPHPPQPHPPMPPMPPVTAPPGAMTPMP | ||||||
Region | 1-41 | Disordered | ||||
Sequence: MSPHPPQPHPPMPPMPPVTAPPGAMTPMPPVPADAQKLHQS | ||||||
Domain | 322-432 | PAZ | ||||
Sequence: TVIQKLFDITGQDPSNGLNNMTREKAAAVIKGLDCYSTYTNRKRHLRIEGIFHESATKTRFELPDGKTCSIAEYYADKYKISLQYPNANLVVCKDRGNNNYFPAELMTVSR | ||||||
Domain | 636-899 | Piwi | ||||
Sequence: VKDGKRLTLENIINKTNVKLGGLNYTVSDAKKSMTDEQLIIGVGVSAPPAGTKYMMDNKGHLNPQIIGFASNAVANHEFVGDFVLAPSGQDTMASIEDVLQNSIDLFEKNRKALPKRIIIYRSGASEGSHASILAYEIPLARAIIHGYSKEIKLIFIVVTKEHSYRFFRDQLRSGGKATEMNIPPGIVLDNAVTNPACKQFFLNGHTTLQGTAKTPLYTVLADDCKAPMDRLEELTFTLCHHHQIVSLSTSIPTPLYVANEYAK |
Sequence similarities
Belongs to the Argonaute family. WAGO subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length945
- Mass (Da)105,437
- Last updated1996-11-01 v1
- Checksum6751A5184FD54BF7
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-29 | Pro residues | ||||
Sequence: MSPHPPQPHPPMPPMPPVTAPPGAMTPMP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX284601 EMBL· GenBank· DDBJ | CAA95839.1 EMBL· GenBank· DDBJ | Genomic DNA |