Q21455 · HMT13_CAEEL
- ProteinProton myo-inositol cotransporter hmit-1.3
- Genehmit-1.3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids604 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
H+-myo-inositol cotransporter.
Catalytic activity
- H+(out) + myo-inositol(out) = H+(in) + myo-inositol(in)H+ (out)CHEBI:15378
+ myo-inositol (out)CHEBI:17268= H+ (in)CHEBI:15378+ myo-inositol (in)CHEBI:17268
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | perikaryon | |
Molecular Function | myo-inositol:proton symporter activity | |
Biological Process | myo-inositol transport | |
Biological Process | transmembrane transport |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProton myo-inositol cotransporter hmit-1.3
- Short namesH(+)-myo-inositol cotransporter hmit-1.3
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ21455
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Note: Localizes to the endfoot region of glial cells where the cilia of sensory neurons are embedded.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-23 | Cytoplasmic | ||||
Sequence: MVQVAPVAAGAGSGQTRPSSDPK | ||||||
Transmembrane | 24-44 | Helical; Name=1 | ||||
Sequence: TGWFVYMLAFSAVIGGFLFGY | ||||||
Topological domain | 45-71 | Extracellular | ||||
Sequence: DTGIVSAAMLYVPNASGIKPLDSVWQE | ||||||
Transmembrane | 72-92 | Helical; Name=2 | ||||
Sequence: IIVSITPGVAAIGSLCSGPGS | ||||||
Topological domain | 93-99 | Cytoplasmic | ||||
Sequence: DFLGRKK | ||||||
Transmembrane | 100-120 | Helical; Name=3 | ||||
Sequence: IIIGASVTFTIGAIICAAAWT | ||||||
Topological domain | 121 | Extracellular | ||||
Sequence: K | ||||||
Transmembrane | 122-142 | Helical; Name=4 | ||||
Sequence: IILLIGRILLGLAIGFASMIV | ||||||
Topological domain | 143-157 | Cytoplasmic | ||||
Sequence: PIYVSEASPSHIRGK | ||||||
Transmembrane | 158-178 | Helical; Name=5 | ||||
Sequence: LVTGFQLMITVGLVIANIIGG | ||||||
Topological domain | 179-191 | Extracellular | ||||
Sequence: AFSYVDPDQVGWR | ||||||
Transmembrane | 192-212 | Helical; Name=6 | ||||
Sequence: LMFAFAAVPAIIQFVCFLFLP | ||||||
Topological domain | 213-281 | Cytoplasmic | ||||
Sequence: ESPRWLYEHGRTVEAREVLTRIYNGHTEWVDYEINEISFSYEEELRAKAEHAGNGPTIIRILKTPHVRK | ||||||
Transmembrane | 282-302 | Helical; Name=7 | ||||
Sequence: AMIIGSLLQMFQQLSGINTVM | ||||||
Topological domain | 303-320 | Extracellular | ||||
Sequence: YYTGNIIRSAGVKDNHTT | ||||||
Transmembrane | 321-341 | Helical; Name=8 | ||||
Sequence: IWISVGTSAINFLGTFIPIAL | ||||||
Topological domain | 342-351 | Cytoplasmic | ||||
Sequence: VERVGRRVLL | ||||||
Transmembrane | 352-372 | Helical; Name=9 | ||||
Sequence: LVSMIGVILFLIAMGVSFLLI | ||||||
Topological domain | 373-468 | Extracellular | ||||
Sequence: NNDSLRTFDQQNYTLNYNPSVKHAAKCLKYSNCDFCVTDENCGFCESKVAKKGYCLPFPSDDSSDYSATGICEFSNLTNNGTDFEWEDTYCHTKFT | ||||||
Transmembrane | 469-489 | Helical; Name=10 | ||||
Sequence: VLPIIIMVFYLLSFSAGYAPL | ||||||
Topological domain | 490-505 | Cytoplasmic | ||||
Sequence: PWVLNAEFYPLWARST | ||||||
Transmembrane | 506-526 | Helical; Name=11 | ||||
Sequence: AVSVSTACNWIFNLIVSLTFL | ||||||
Topological domain | 527-535 | Extracellular | ||||
Sequence: SLSQAATKY | ||||||
Transmembrane | 536-556 | Helical; Name=12 | ||||
Sequence: GTFFIYCGCTMVALVFVFFFV | ||||||
Topological domain | 557-604 | Cytoplasmic | ||||
Sequence: PETKGYSIDEVEMLFMTKEERRKAQKVLDESKEGKHRNSVAMSFDTKF |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000450213 | 1-604 | Proton myo-inositol cotransporter hmit-1.3 | |||
Sequence: MVQVAPVAAGAGSGQTRPSSDPKTGWFVYMLAFSAVIGGFLFGYDTGIVSAAMLYVPNASGIKPLDSVWQEIIVSITPGVAAIGSLCSGPGSDFLGRKKIIIGASVTFTIGAIICAAAWTKIILLIGRILLGLAIGFASMIVPIYVSEASPSHIRGKLVTGFQLMITVGLVIANIIGGAFSYVDPDQVGWRLMFAFAAVPAIIQFVCFLFLPESPRWLYEHGRTVEAREVLTRIYNGHTEWVDYEINEISFSYEEELRAKAEHAGNGPTIIRILKTPHVRKAMIIGSLLQMFQQLSGINTVMYYTGNIIRSAGVKDNHTTIWISVGTSAINFLGTFIPIALVERVGRRVLLLVSMIGVILFLIAMGVSFLLINNDSLRTFDQQNYTLNYNPSVKHAAKCLKYSNCDFCVTDENCGFCESKVAKKGYCLPFPSDDSSDYSATGICEFSNLTNNGTDFEWEDTYCHTKFTVLPIIIMVFYLLSFSAGYAPLPWVLNAEFYPLWARSTAVSVSTACNWIFNLIVSLTFLSLSQAATKYGTFFIYCGCTMVALVFVFFFVPETKGYSIDEVEMLFMTKEERRKAQKVLDESKEGKHRNSVAMSFDTKF | ||||||
Glycosylation | 58 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 317 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 374 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 384 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 448 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 452 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-20 | Disordered | ||||
Sequence: MVQVAPVAAGAGSGQTRPSS |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length604
- Mass (Da)66,562
- Last updated2003-06-01 v3
- Checksum68C0A3794246F084
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX284603 EMBL· GenBank· DDBJ | CAA86519.2 EMBL· GenBank· DDBJ | Genomic DNA |