Q21441 · KI26L_CAEEL
- ProteinKinesin-like protein vab-8
- Genevab-8
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1066 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Required for posterior migration of cells and axon growth cones during nervous system assembly.
Isoform a
Required for posterior migration of the axon growth cone and the ALM cell body (PubMed:17237778, PubMed:9581759).
May enhance posterior migration by regulating the subcellular location or stability of guidance cue receptors such as sax-3 and unc-40, promoting their localization to the cell surface (PubMed:17237778).
In PLM neuron, regulates innexin unc-9 gap junction turnover by suppressing unc-9 transport out of the gap junctions (PubMed:27015090).
May enhance posterior migration by regulating the subcellular location or stability of guidance cue receptors such as sax-3 and unc-40, promoting their localization to the cell surface (PubMed:17237778).
In PLM neuron, regulates innexin unc-9 gap junction turnover by suppressing unc-9 transport out of the gap junctions (PubMed:27015090).
Isoform b
Specifically required for CAN cell migration.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | microtubule | |
Cellular Component | striated muscle thin filament | |
Molecular Function | ATP binding | |
Molecular Function | microtubule binding | |
Molecular Function | microtubule motor activity | |
Biological Process | axon guidance | |
Biological Process | cell migration | |
Biological Process | egg-laying behavior | |
Biological Process | locomotion | |
Biological Process | mesodermal cell migration | |
Biological Process | microtubule-based movement | |
Biological Process | negative regulation of motor neuron migration | |
Biological Process | neuron migration | |
Biological Process | regulation of cell migration | |
Biological Process | vulval development |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameKinesin-like protein vab-8
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ21441
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000307306 | 1-1066 | Kinesin-like protein vab-8 | |||
Sequence: MEACSSKTSLLLHSPLRTIPKLRLCASISSEDVAHGRCSLTDQHLQIEGKNYSKTTFDHIFRTDATQDDMYTAFLSDTINSVFAGNDATVLAMGAKTNGKDERLYGNSVSRNGLVQMAITQLMNALDDNKDSEERIQVRMSAIMVSQNESSIVDLLSPFNPDPRHRVVKIVDDARTGVFIDNESEIRVETIDQALFYLNTAVDHRMIQDEHTHRTSHVFISLSLYSYKMGDKMQGGRRRLCFLDMGIGERNSTNGGMTMPALGSILLAMVQRNKHIPSRDSSVCQLIRCALSTSRFTTFVFSFGAKSDDNENIAHLACKIARTRAKSMVGHGRKSSGTMSTGTMESNSSSCGTTTITPGGTPRTQRRFELESGSELSAAETVIFLGPNSSRTASPASTTMPFTPTSIRPLHRTTRNHSGVEALSKPLSVETKSSPTHNCHDGCIHSIPPMLRGHTPFLSASLKLYDELCSPPSSSRASPAPPAAFGGKTSEKREDFGIMIAQPSIPLMKAKSKYNLDDGKMKQIMQWMETSEAPPILFSSPCYENSATSVEELRECVGILSHPLEDIIEQEEESMRTSTATTGGSKKDHPLRILSKQDLNVEPEIKDKQEENELELVMAASLSSMRSHDILAKLEAMRNAQNGNSVQNIGNSQSNTDMDVSEMDVYRRASHLEEYAMQRVREIEENKLKNKKKIKLGLNCCQQQSMISSGSTVVDWSQIERKKEKEREVHEEEMRKEMLRERRAKLKITELEIKRERNLIDKELDDKKGIANSIARQLQHFSLSPCRGGRTHRSVSTHRIDPPNASLPSTPTMSHKKVIGGSLAKLSASGASGSTGAPPSPALGYHQSLPRHSKLPTSVNGRRASAERERKSNKASRNSCSKERKISGSKEELQWRSPYAQMTSPKSYGGPGTSSSGRGSSAPGSDFETPVVSTTEKSANGTIPRSKRQSYSASSGYESANDYHIYSTTNKKPHILDKKRNEEKLSLVRQADEIRHRQWQLKKELEEAKRAIGQEDDAKMIANSSDQRLNGLSRTTMIDAMLQENRILEKRLVACRNHSMLVTTFI |
Post-translational modification
Phosphorylated by unc-51.
Keywords
- PTM
Proteomic databases
Interaction
Subunit
Interacts with unc-51 and unc-73 (PubMed:15539493, PubMed:17237778).
Isoform a: Interacts with unc-33 isoform c (PubMed:27015090).
Isoform a: Interacts with unc-33 isoform c (PubMed:27015090).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q21441 | unc-51 Q23023 | 4 | EBI-2412191, EBI-329049 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 15-326 | Kinesin motor | ||||
Sequence: PLRTIPKLRLCASISSEDVAHGRCSLTDQHLQIEGKNYSKTTFDHIFRTDATQDDMYTAFLSDTINSVFAGNDATVLAMGAKTNGKDERLYGNSVSRNGLVQMAITQLMNALDDNKDSEERIQVRMSAIMVSQNESSIVDLLSPFNPDPRHRVVKIVDDARTGVFIDNESEIRVETIDQALFYLNTAVDHRMIQDEHTHRTSHVFISLSLYSYKMGDKMQGGRRRLCFLDMGIGERNSTNGGMTMPALGSILLAMVQRNKHIPSRDSSVCQLIRCALSTSRFTTFVFSFGAKSDDNENIAHLACKIARTRAK | ||||||
Region | 328-367 | Disordered | ||||
Sequence: MVGHGRKSSGTMSTGTMESNSSSCGTTTITPGGTPRTQRR | ||||||
Region | 332-514 | Interaction with unc-51 | ||||
Sequence: GRKSSGTMSTGTMESNSSSCGTTTITPGGTPRTQRRFELESGSELSAAETVIFLGPNSSRTASPASTTMPFTPTSIRPLHRTTRNHSGVEALSKPLSVETKSSPTHNCHDGCIHSIPPMLRGHTPFLSASLKLYDELCSPPSSSRASPAPPAAFGGKTSEKREDFGIMIAQPSIPLMKAKSKY | ||||||
Compositional bias | 333-362 | Polar residues | ||||
Sequence: RKSSGTMSTGTMESNSSSCGTTTITPGGTP | ||||||
Region | 387-411 | Disordered | ||||
Sequence: PNSSRTASPASTTMPFTPTSIRPLH | ||||||
Region | 402-874 | Interaction with unc-73 | ||||
Sequence: FTPTSIRPLHRTTRNHSGVEALSKPLSVETKSSPTHNCHDGCIHSIPPMLRGHTPFLSASLKLYDELCSPPSSSRASPAPPAAFGGKTSEKREDFGIMIAQPSIPLMKAKSKYNLDDGKMKQIMQWMETSEAPPILFSSPCYENSATSVEELRECVGILSHPLEDIIEQEEESMRTSTATTGGSKKDHPLRILSKQDLNVEPEIKDKQEENELELVMAASLSSMRSHDILAKLEAMRNAQNGNSVQNIGNSQSNTDMDVSEMDVYRRASHLEEYAMQRVREIEENKLKNKKKIKLGLNCCQQQSMISSGSTVVDWSQIERKKEKEREVHEEEMRKEMLRERRAKLKITELEIKRERNLIDKELDDKKGIANSIARQLQHFSLSPCRGGRTHRSVSTHRIDPPNASLPSTPTMSHKKVIGGSLAKLSASGASGSTGAPPSPALGYHQSLPRHSKLPTSVNGRRASAERERKSNK | ||||||
Region | 471-491 | Disordered | ||||
Sequence: PPSSSRASPAPPAAFGGKTSE | ||||||
Region | 514-715 | Interaction with unc-51 | ||||
Sequence: YNLDDGKMKQIMQWMETSEAPPILFSSPCYENSATSVEELRECVGILSHPLEDIIEQEEESMRTSTATTGGSKKDHPLRILSKQDLNVEPEIKDKQEENELELVMAASLSSMRSHDILAKLEAMRNAQNGNSVQNIGNSQSNTDMDVSEMDVYRRASHLEEYAMQRVREIEENKLKNKKKIKLGLNCCQQQSMISSGSTVVD | ||||||
Region | 569-592 | Disordered | ||||
Sequence: EQEEESMRTSTATTGGSKKDHPLR | ||||||
Coiled coil | 717-765 | |||||
Sequence: SQIERKKEKEREVHEEEMRKEMLRERRAKLKITELEIKRERNLIDKELD | ||||||
Region | 784-815 | Disordered | ||||
Sequence: SPCRGGRTHRSVSTHRIDPPNASLPSTPTMSH | ||||||
Compositional bias | 798-815 | Polar residues | ||||
Sequence: HRIDPPNASLPSTPTMSH | ||||||
Region | 827-957 | Disordered | ||||
Sequence: SASGASGSTGAPPSPALGYHQSLPRHSKLPTSVNGRRASAERERKSNKASRNSCSKERKISGSKEELQWRSPYAQMTSPKSYGGPGTSSSGRGSSAPGSDFETPVVSTTEKSANGTIPRSKRQSYSASSGY | ||||||
Compositional bias | 863-891 | Basic and acidic residues | ||||
Sequence: RASAERERKSNKASRNSCSKERKISGSKE | ||||||
Compositional bias | 894-957 | Polar residues | ||||
Sequence: QWRSPYAQMTSPKSYGGPGTSSSGRGSSAPGSDFETPVVSTTEKSANGTIPRSKRQSYSASSGY | ||||||
Coiled coil | 987-1021 | |||||
Sequence: LVRQADEIRHRQWQLKKELEEAKRAIGQEDDAKMI |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q21441-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Namea
- Synonymsvab-8l
- Length1,066
- Mass (Da)118,211
- Last updated2002-10-01 v3
- ChecksumA848740A95EC6EF0
Q21441-2
- Nameb
- Synonymsvab-8s
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A8DZ45 | A8DZ45_CAEEL | vab-8 | 617 |
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_028697 | 1-484 | in isoform b | |||
Sequence: Missing | ||||||
Compositional bias | 333-362 | Polar residues | ||||
Sequence: RKSSGTMSTGTMESNSSSCGTTTITPGGTP | ||||||
Alternative sequence | VSP_028698 | 485-513 | in isoform b | |||
Sequence: FGGKTSEKREDFGIMIAQPSIPLMKAKSK → MPQTSALFEIRRSQITFMEYFKYTWQRLM | ||||||
Compositional bias | 798-815 | Polar residues | ||||
Sequence: HRIDPPNASLPSTPTMSH | ||||||
Compositional bias | 863-891 | Basic and acidic residues | ||||
Sequence: RASAERERKSNKASRNSCSKERKISGSKE | ||||||
Compositional bias | 894-957 | Polar residues | ||||
Sequence: QWRSPYAQMTSPKSYGGPGTSSSGRGSSAPGSDFETPVVSTTEKSANGTIPRSKRQSYSASSGY |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF108229 EMBL· GenBank· DDBJ | AAF17300.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF108229 EMBL· GenBank· DDBJ | AAF17301.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX284605 EMBL· GenBank· DDBJ | CAB01577.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z78201 EMBL· GenBank· DDBJ | CAB01577.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX284605 EMBL· GenBank· DDBJ | CAB54275.1 EMBL· GenBank· DDBJ | Genomic DNA |