Q21227 · APR1_CAEEL
- ProteinAdenomatous polyposis coli protein-related protein 1
- Geneapr-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1188 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Has a role in endoderm cell specification and pharyngeal development (PubMed:9288750).
Required for the migration of epithelial cells, organization of the anterior seam cells and ceh-13 expression during embryo morphogenesis. Prevents hyperactivation of the Wnt signaling pathway during endoderm development, probably by preventing hmp-2 nuclear translocation (PubMed:20805471).
During larval development, apr-1 is required for expression of lin-39 in P3-8.p (PubMed:10766743).
Shown to negatively regulate Wnt signaling in vulval precursor cells (PubMed:12023306).
Has a role in cell division by establishing the polarity of the mother cell which forms the asymmetries of the daughter nuclei (PubMed:17276345).
During the L4 larval stage, it is required for the asymmetric division and self-renewal of seam cells (PubMed:19607822).
Thought to regulate export of wrm-1 from the nucleus possibly as part of a complex involving pry-1 (PubMed:12023307).
Required for the migration of epithelial cells, organization of the anterior seam cells and ceh-13 expression during embryo morphogenesis. Prevents hyperactivation of the Wnt signaling pathway during endoderm development, probably by preventing hmp-2 nuclear translocation (PubMed:20805471).
During larval development, apr-1 is required for expression of lin-39 in P3-8.p (PubMed:10766743).
Shown to negatively regulate Wnt signaling in vulval precursor cells (PubMed:12023306).
Has a role in cell division by establishing the polarity of the mother cell which forms the asymmetries of the daughter nuclei (PubMed:17276345).
During the L4 larval stage, it is required for the asymmetric division and self-renewal of seam cells (PubMed:19607822).
Thought to regulate export of wrm-1 from the nucleus possibly as part of a complex involving pry-1 (PubMed:12023307).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenomatous polyposis coli protein-related protein 1
- Short namesAPC-related protein 1
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ21227
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Found in clusters near the ends of microtubules that extend into regions of actively migrating plasma membranes. Shuttles between the cytoplasm and nucleus.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Worms exhibit lack of endoderm, excessive pharyngeal tissue and premature division of the E daughter blastomeres during embryogenesis. Two-thirds arrest during embryogenesis and the remaining third during the L1 stage (PubMed:9288750).
RNAi-mediated knockdown causes partial nuclear re-localization of hmp-2 in the embryonic epidermis and the production of supernumerary gut nuclei probably resulting from epithelial cell hyperproliferation (PubMed:20805471).
RNAi-mediated knockdown causes partial nuclear re-localization of hmp-2 in the embryonic epidermis and the production of supernumerary gut nuclei probably resulting from epithelial cell hyperproliferation (PubMed:20805471).
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 338 | In bp298; at the L4 larval stage, seam cells divide asymmetrically as opposed to symmetrically leading to an increased number of seam cells at the young adult stage. Defective asymmetric division of the V5.p seam cell and 45.5% of animals develop two postdeirids due to symmetric division of the V5.p seam cell. | ||||
Sequence: G → E |
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000347250 | 1-1188 | Adenomatous polyposis coli protein-related protein 1 | |||
Sequence: MSSSSSDENETTIHRTGSNTGGSGIYSQPRAGSSKRTSNVRHDVSDVDDEEEHYARFREDTAIEVDDAITVLLSSLHFEHKRDIVPTDEDDNKLRELHEKIFALITSESDVNRKRRLKKALPASNCVREQVYYLRRKPSTPPASYYHRLNAALHTIVKESFGEEYRKVATVLGLVEALAEVLILEVHTFGINETNPGEHRNIRKLIANALTNLTYGQIHSKRRLCSYDGFIRCVVRIVIESPNITQVYAGLIRNLSWNADSGMSEALQPTVHALSIAAVHAHTHRFDVTATLSALWNLAGHSVENKRTICDTPNCLKVLASLLSPDARFTSLVDSATGILKYVSQYLANTSTHLELRSLLITRMLTLLKSASFTCVTNTLGAIANLIVKDPHMQQMIRQDMAAVQQLNVLRNSNRDDIRTAVKSVLNTLNQPCSHRYGDMSHSVGGGATGMQMLSEPQLQMQTSHHAYHGTASPRLLSLRATRASPGKYIQPQAQQQLIQTPQVDQRSSSLPRHFAVQRNGFVMAQSYNQQMDQHQQQQMIYQLQQQQQIMFQTEDQAQMEHHQQIMYLQQQQQQFHQIQQQQQMQKAQEADPVPPTDDDLDIPTSTVMGTRSNSERSLGSMNPGSVMTNWNSSLDTAANSSRALSPVSYNDIPASPTMCAQVFNLPKSTESEHHQLTSQQQNTTHYSSGSANTMTRSDGATTVPMDNIITPTYAILNPILVHEQTPNGTVPRKTSEELDSPDDVLPGPSLEEEEGDYAIIGGAAQKTDDELLTRSIQSEMPTSSSTPKMKVSPRLNGFFSPTQKTTSSPAWSHPDTSPIPKSSSHRTQPNRRQDASDADRLLMESIMSEMPKSRIISPRLAGTQQYLEPEPERRSHSKNEEADRRDAFTASHEPSDHNGIDVARGSDWSPQQQLHRMESLESQASSEDSFGLTAEEPNSSTSGAAANTMRFDDEIDASLPMDCVDDDDYDYTYDHFEDYEDEEDPDATQFDDGVDAQLTIDCSMISSGSGSSQRNETTTTSRDSKALATSTPKGSASSLPGVRQATRVSTNGKSRLPVPKTNGSLVDKNPKPIIASRRPRLPPKPTLLKDKHYPEEDSIENQTRDDTIYVNAPVVEAEQERIYMNALKQQKNIEQSPSIGNGSPIAKSAIVTPYNYQKPPFTGRNNGEMSNEKSVTPNPKQMLVTIV |
Proteomic databases
Expression
Tissue specificity
During the L1 stage, expressed in vulval precursor cells (P3-8.p), seam cells and excretory cells.
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-35 | Polar residues | ||||
Sequence: MSSSSSDENETTIHRTGSNTGGSGIYSQPRAGSSK | ||||||
Region | 1-50 | Disordered | ||||
Sequence: MSSSSSDENETTIHRTGSNTGGSGIYSQPRAGSSKRTSNVRHDVSDVDDE | ||||||
Region | 1-486 | Required for interaction with bar-1 and hmp-2 | ||||
Sequence: MSSSSSDENETTIHRTGSNTGGSGIYSQPRAGSSKRTSNVRHDVSDVDDEEEHYARFREDTAIEVDDAITVLLSSLHFEHKRDIVPTDEDDNKLRELHEKIFALITSESDVNRKRRLKKALPASNCVREQVYYLRRKPSTPPASYYHRLNAALHTIVKESFGEEYRKVATVLGLVEALAEVLILEVHTFGINETNPGEHRNIRKLIANALTNLTYGQIHSKRRLCSYDGFIRCVVRIVIESPNITQVYAGLIRNLSWNADSGMSEALQPTVHALSIAAVHAHTHRFDVTATLSALWNLAGHSVENKRTICDTPNCLKVLASLLSPDARFTSLVDSATGILKYVSQYLANTSTHLELRSLLITRMLTLLKSASFTCVTNTLGAIANLIVKDPHMQQMIRQDMAAVQQLNVLRNSNRDDIRTAVKSVLNTLNQPCSHRYGDMSHSVGGGATGMQMLSEPQLQMQTSHHAYHGTASPRLLSLRATRASP | ||||||
Compositional bias | 36-50 | Basic and acidic residues | ||||
Sequence: RTSNVRHDVSDVDDE | ||||||
Repeat | 314-358 | ARM | ||||
Sequence: NCLKVLASLLSPDARFTSLVDSATGILKYVSQYLANTSTHLELRS | ||||||
Region | 579-624 | Disordered | ||||
Sequence: IQQQQQMQKAQEADPVPPTDDDLDIPTSTVMGTRSNSERSLGSMNP | ||||||
Region | 600-1188 | Required for interaction with pry-1 | ||||
Sequence: DLDIPTSTVMGTRSNSERSLGSMNPGSVMTNWNSSLDTAANSSRALSPVSYNDIPASPTMCAQVFNLPKSTESEHHQLTSQQQNTTHYSSGSANTMTRSDGATTVPMDNIITPTYAILNPILVHEQTPNGTVPRKTSEELDSPDDVLPGPSLEEEEGDYAIIGGAAQKTDDELLTRSIQSEMPTSSSTPKMKVSPRLNGFFSPTQKTTSSPAWSHPDTSPIPKSSSHRTQPNRRQDASDADRLLMESIMSEMPKSRIISPRLAGTQQYLEPEPERRSHSKNEEADRRDAFTASHEPSDHNGIDVARGSDWSPQQQLHRMESLESQASSEDSFGLTAEEPNSSTSGAAANTMRFDDEIDASLPMDCVDDDDYDYTYDHFEDYEDEEDPDATQFDDGVDAQLTIDCSMISSGSGSSQRNETTTTSRDSKALATSTPKGSASSLPGVRQATRVSTNGKSRLPVPKTNGSLVDKNPKPIIASRRPRLPPKPTLLKDKHYPEEDSIENQTRDDTIYVNAPVVEAEQERIYMNALKQQKNIEQSPSIGNGSPIAKSAIVTPYNYQKPPFTGRNNGEMSNEKSVTPNPKQMLVTIV | ||||||
Compositional bias | 604-624 | Polar residues | ||||
Sequence: PTSTVMGTRSNSERSLGSMNP | ||||||
Region | 670-702 | Disordered | ||||
Sequence: TESEHHQLTSQQQNTTHYSSGSANTMTRSDGAT | ||||||
Region | 726-751 | Disordered | ||||
Sequence: TPNGTVPRKTSEELDSPDDVLPGPSL | ||||||
Compositional bias | 778-827 | Polar residues | ||||
Sequence: QSEMPTSSSTPKMKVSPRLNGFFSPTQKTTSSPAWSHPDTSPIPKSSSHR | ||||||
Region | 778-952 | Disordered | ||||
Sequence: QSEMPTSSSTPKMKVSPRLNGFFSPTQKTTSSPAWSHPDTSPIPKSSSHRTQPNRRQDASDADRLLMESIMSEMPKSRIISPRLAGTQQYLEPEPERRSHSKNEEADRRDAFTASHEPSDHNGIDVARGSDWSPQQQLHRMESLESQASSEDSFGLTAEEPNSSTSGAAANTMRF | ||||||
Compositional bias | 870-901 | Basic and acidic residues | ||||
Sequence: PEPERRSHSKNEEADRRDAFTASHEPSDHNGI | ||||||
Compositional bias | 906-948 | Polar residues | ||||
Sequence: GSDWSPQQQLHRMESLESQASSEDSFGLTAEEPNSSTSGAAAN | ||||||
Compositional bias | 1003-1059 | Polar residues | ||||
Sequence: CSMISSGSGSSQRNETTTTSRDSKALATSTPKGSASSLPGVRQATRVSTNGKSRLPV | ||||||
Region | 1003-1092 | Disordered | ||||
Sequence: CSMISSGSGSSQRNETTTTSRDSKALATSTPKGSASSLPGVRQATRVSTNGKSRLPVPKTNGSLVDKNPKPIIASRRPRLPPKPTLLKDK | ||||||
Region | 1157-1181 | Disordered | ||||
Sequence: YQKPPFTGRNNGEMSNEKSVTPNPK | ||||||
Compositional bias | 1159-1181 | Polar residues | ||||
Sequence: KPPFTGRNNGEMSNEKSVTPNPK |
Sequence similarities
Belongs to the adenomatous polyposis coli (APC) family.
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q21227-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Nameb
- Length1,188
- Mass (Da)131,990
- Last updated2008-09-02 v2
- ChecksumF3CDA53B5D3527A0
Q21227-2
- Namea
- Differences from canonical
- 552-553: Missing
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1I6CM53 | A0A1I6CM53_CAEEL | apr-1 | 892 |
Features
Showing features for compositional bias, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-35 | Polar residues | ||||
Sequence: MSSSSSDENETTIHRTGSNTGGSGIYSQPRAGSSK | ||||||
Compositional bias | 36-50 | Basic and acidic residues | ||||
Sequence: RTSNVRHDVSDVDDE | ||||||
Alternative sequence | VSP_052859 | 552-553 | in isoform a | |||
Sequence: Missing | ||||||
Compositional bias | 604-624 | Polar residues | ||||
Sequence: PTSTVMGTRSNSERSLGSMNP | ||||||
Compositional bias | 778-827 | Polar residues | ||||
Sequence: QSEMPTSSSTPKMKVSPRLNGFFSPTQKTTSSPAWSHPDTSPIPKSSSHR | ||||||
Compositional bias | 870-901 | Basic and acidic residues | ||||
Sequence: PEPERRSHSKNEEADRRDAFTASHEPSDHNGI | ||||||
Compositional bias | 906-948 | Polar residues | ||||
Sequence: GSDWSPQQQLHRMESLESQASSEDSFGLTAEEPNSSTSGAAAN | ||||||
Compositional bias | 1003-1059 | Polar residues | ||||
Sequence: CSMISSGSGSSQRNETTTTSRDSKALATSTPKGSASSLPGVRQATRVSTNGKSRLPV | ||||||
Compositional bias | 1159-1181 | Polar residues | ||||
Sequence: KPPFTGRNNGEMSNEKSVTPNPK |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF013950 EMBL· GenBank· DDBJ | AAC47747.1 EMBL· GenBank· DDBJ | mRNA | ||
BX284601 EMBL· GenBank· DDBJ | CAB00045.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX284601 EMBL· GenBank· DDBJ | CAB00048.1 EMBL· GenBank· DDBJ | Genomic DNA |