Lactobacillus casei pretreatment triggers the TLR mediated and rack-1 dependent p38 MAPK signaling pathway in nematodes. rack-1 is necessary in activating the p38 MAPK pathway by Lactobacillus casei.
RACK-1 controls the biogenesis of a subset of miRNAs including let-7 and in this way plays a role in the heterochronic gene pathway during C. elegans development.
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