Q21041 · VER4_CAEEL
- ProteinTyrosine-protein kinase receptor ver-4
- Genever-4
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1216 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Receptor tyrosine kinase which may be involved, downstream of pvf-1, in the positioning of ray 1, the most anterior ray sensillum in the male tail.
Catalytic activity
- ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]
Features
Showing features for binding site, active site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | receptor complex | |
Molecular Function | ATP binding | |
Molecular Function | transmembrane receptor protein tyrosine kinase activity | |
Biological Process | nematode male tail tip morphogenesis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine-protein kinase receptor ver-4
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ21041
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-789 | Extracellular | ||||
Sequence: MRVSLTEFLVLAQVVTTLQPITIKVDFHEVKHHESIGDYVELVEGKNRDISLTCYGQHKNLKIEPPKREEHAGFPEIGIRTSAEWKKNEYWFLLKNVRQCDTGSYYCVSDEFKESMLQNTVHIFVRKLDIFVPLKTIYHEHNGSEIIIPCKTTKFVDTKNVELYVNQVKLNSALQGYDQRYGFKLTKNMYTMKPNSTVFFECKYTNDSNQDLDYYISNSDPDATLIDQYFFYWEKSNDVPYVGNNYSITCHLVYIGSDSLRPLNHQEIVLECPQNQCDGGYNNQSAHEIEKRSSGLRFGDPSSQDIVEKNTMLRYDRLSVYDRKTSRTVNFQNLTSEDSGIYRCTWRNRSKTNIVLDYDLNFNQKGTQIKIIETSKQRLKMRKNESTLLFVKFAVFPINKKNYTAKWSRLYNSTVEGGQQVETIRNGFFRQITTKTSGRNVFLETLNLKSPKIEMSGIYVLSISNMDIVQQVKWIIEVENDEPNAQLTIRDPLTLNISNQLFLPLNTNLSIFCLAVSSSPTDVIFEYRTDENEWFRGFYKNKLRKIDDTFEKGFIYNFVLAKRTDFKCINVKKKKTSTKFITVTSNANKTFHEIEKSVNATKTEPSDIIFEGDNVRLTCVVPYGAVEFDVFWKFENPKMLKYTTFPAMHPVKDRYKRVILNVRNITIDFTGTYYCIVKNKEFEHRFETSISVEKVSPPFLLNNNSRSIISASNGQMFDINCKVNGVPTPDYTWFKDGYPYTKGKVIGNALHVSKAEKRDNGIFWCSATNRAGTTIDYIEVKVAGASSSS | ||||||
Transmembrane | 790-810 | Helical | ||||
Sequence: FFWLFITFFAFVVVGIVVSLL | ||||||
Topological domain | 811-1216 | Cytoplasmic | ||||
Sequence: WKLFGQKDLKPSELSLNNLKRATDEYQKYTVSEKINNLPVEERIDYLTYNEDYEIDLENLEILETLGSGQFGIVKKGYLNMASSKNFGFESRLSVAIKSSTDSSNMELQKMFFEELKLMCAIPKHPNVLSLVGAVTKNMEIGELFIVTELIDGGNLREFLRERRDVFANELVEKGYIFLTNVRENVPKREVEKEQLLIDEFNSLCTSDLLSIGLQIANGMDWLANIPCVHRDLACRNVLISKTKIIRIADFGLAKKHTDKAYYRVRESLDTPLPVRWMPLESITDLTFTQKSDVWSYGICLYEIFTLGGTPYPDCPNFSLVEYIKTGNINKRPSNCHKDVYKIMKMCWQASPDDRPTFAECIKLFKNHIQYFASKLLQQIEKDLECEKNNQQKFHYWVQKPTQLFF |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000434516 | 1-1216 | Tyrosine-protein kinase receptor ver-4 | |||
Sequence: MRVSLTEFLVLAQVVTTLQPITIKVDFHEVKHHESIGDYVELVEGKNRDISLTCYGQHKNLKIEPPKREEHAGFPEIGIRTSAEWKKNEYWFLLKNVRQCDTGSYYCVSDEFKESMLQNTVHIFVRKLDIFVPLKTIYHEHNGSEIIIPCKTTKFVDTKNVELYVNQVKLNSALQGYDQRYGFKLTKNMYTMKPNSTVFFECKYTNDSNQDLDYYISNSDPDATLIDQYFFYWEKSNDVPYVGNNYSITCHLVYIGSDSLRPLNHQEIVLECPQNQCDGGYNNQSAHEIEKRSSGLRFGDPSSQDIVEKNTMLRYDRLSVYDRKTSRTVNFQNLTSEDSGIYRCTWRNRSKTNIVLDYDLNFNQKGTQIKIIETSKQRLKMRKNESTLLFVKFAVFPINKKNYTAKWSRLYNSTVEGGQQVETIRNGFFRQITTKTSGRNVFLETLNLKSPKIEMSGIYVLSISNMDIVQQVKWIIEVENDEPNAQLTIRDPLTLNISNQLFLPLNTNLSIFCLAVSSSPTDVIFEYRTDENEWFRGFYKNKLRKIDDTFEKGFIYNFVLAKRTDFKCINVKKKKTSTKFITVTSNANKTFHEIEKSVNATKTEPSDIIFEGDNVRLTCVVPYGAVEFDVFWKFENPKMLKYTTFPAMHPVKDRYKRVILNVRNITIDFTGTYYCIVKNKEFEHRFETSISVEKVSPPFLLNNNSRSIISASNGQMFDINCKVNGVPTPDYTWFKDGYPYTKGKVIGNALHVSKAEKRDNGIFWCSATNRAGTTIDYIEVKVAGASSSSFFWLFITFFAFVVVGIVVSLLWKLFGQKDLKPSELSLNNLKRATDEYQKYTVSEKINNLPVEERIDYLTYNEDYEIDLENLEILETLGSGQFGIVKKGYLNMASSKNFGFESRLSVAIKSSTDSSNMELQKMFFEELKLMCAIPKHPNVLSLVGAVTKNMEIGELFIVTELIDGGNLREFLRERRDVFANELVEKGYIFLTNVRENVPKREVEKEQLLIDEFNSLCTSDLLSIGLQIANGMDWLANIPCVHRDLACRNVLISKTKIIRIADFGLAKKHTDKAYYRVRESLDTPLPVRWMPLESITDLTFTQKSDVWSYGICLYEIFTLGGTPYPDCPNFSLVEYIKTGNINKRPSNCHKDVYKIMKMCWQASPDDRPTFAECIKLFKNHIQYFASKLLQQIEKDLECEKNNQQKFHYWVQKPTQLFF | ||||||
Glycosylation | 142 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 195 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 206 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 245 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 283 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 333 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 348 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 384 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 402 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 412 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 496 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 508 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 588 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 599 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 619↔675 | |||||
Sequence: CVVPYGAVEFDVFWKFENPKMLKYTTFPAMHPVKDRYKRVILNVRNITIDFTGTYYC | ||||||
Glycosylation | 664 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 703 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 721↔765 | |||||
Sequence: CKVNGVPTPDYTWFKDGYPYTKGKVIGNALHVSKAEKRDNGIFWC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 596-691 | Ig-like C2-type 1 | ||||
Sequence: KSVNATKTEPSDIIFEGDNVRLTCVVPYGAVEFDVFWKFENPKMLKYTTFPAMHPVKDRYKRVILNVRNITIDFTGTYYCIVKNKEFEHRFETSIS | ||||||
Domain | 697-783 | Ig-like C2-type 2 | ||||
Sequence: PPFLLNNNSRSIISASNGQMFDINCKVNGVPTPDYTWFKDGYPYTKGKVIGNALHVSKAEKRDNGIFWCSATNRAGTTIDYIEVKVA | ||||||
Domain | 870-1181 | Protein kinase | ||||
Sequence: LEILETLGSGQFGIVKKGYLNMASSKNFGFESRLSVAIKSSTDSSNMELQKMFFEELKLMCAIPKHPNVLSLVGAVTKNMEIGELFIVTELIDGGNLREFLRERRDVFANELVEKGYIFLTNVRENVPKREVEKEQLLIDEFNSLCTSDLLSIGLQIANGMDWLANIPCVHRDLACRNVLISKTKIIRIADFGLAKKHTDKAYYRVRESLDTPLPVRWMPLESITDLTFTQKSDVWSYGICLYEIFTLGGTPYPDCPNFSLVEYIKTGNINKRPSNCHKDVYKIMKMCWQASPDDRPTFAECIKLFKNHIQY |
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,216
- Mass (Da)140,906
- Last updated2008-12-16 v2
- Checksum67AFC63D918F177D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX284606 EMBL· GenBank· DDBJ | CAA91991.2 EMBL· GenBank· DDBJ | Genomic DNA |