Q21017 · KIN29_CAEEL
- ProteinSerine/threonine-protein kinase kin-29
- Genekin-29
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids822 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Regulates chemoreceptor expression by phosphorylating the hda-4 class II histone deacetylase (HDAC) and inhibiting the gene repression functions of hda-4 and the mef-2 transcription factor, enabling the correct sensing and transduction of food signals. Role in determining body size, the dauer decision and serotonin-mediated egg laying. May modulate the Sma/Mab pathway and regulates development in the later larval stages.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | histone deacetylase inhibitor activity | |
Molecular Function | metal ion binding | |
Molecular Function | protein kinase activity | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | dauer entry | |
Biological Process | dauer larval development | |
Biological Process | intracellular signal transduction | |
Biological Process | negative regulation of fatty acid biosynthetic process | |
Biological Process | positive regulation of gene expression | |
Biological Process | positive regulation of growth rate | |
Biological Process | positive regulation of multicellular organism growth | |
Biological Process | regulation of multicellular organism growth | |
Biological Process | reproductive process | |
Biological Process | response to heat | |
Biological Process | transforming growth factor beta receptor signaling pathway |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase kin-29
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ21017
Proteomes
Organism-specific databases
Phenotypes & Variants
Disruption phenotype
Defective in the expression of a set of chemoreceptor genes, and exhibit characteristics associated with altered sensory signaling, including increased lifespan, decreased body size, and deregulated entry into the dauer developmental stage. Exhibit defects in food-induced quiescence behavior.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000398619 | 1-822 | Serine/threonine-protein kinase kin-29 | |||
Sequence: MAAPRRRMGLEKIGLYDVGRAIGKGNFATVRIARHKIAKTKVAIKSIDVSALDRENLIKLEREVKIVKVIDHPHIVKSYEIMRVDNMLYIVSEYCSSGELYETLIEKGRVAENVARKWFSETASAVAYLHSQGIVHRDLKAENILLGKNSNIKIIDFGFSNFQTGDQLLNTWCGSPPYAAPELLLGNSYDGMKADIWSMGVLLYILVAGGFPFPSDSVNKLKRSVLSGLVKIPYWVSVECADFIRKMLVLNPGKRYTIQNVLQHRWMHIRDDVQKNQAAQLLEAIPSSSIEIRQQSTKLNPTIMMFMQQHGKWSEEQIIDAVLGRDFESPIFATYELLADKVKKGTLEGTGEEFPRRGSRGSILSGKANVDEQPLTPTISAHQLAQLNLSSPDCDSDDSSNSDLCDDSPMSSMGPMNHERQFGTPHGLDIIGNRFENRRHTLCASEQLLSPNMMGQFPPPNLLLNNFSMNPPLGFPPMPEGQAAEFPLPSLHPAFATIPIADLSKMLPVPKSERRASAGETLLPTNFDLTQHLANLPAPPISFPTVEEEGKSYLSKYGGKRNTVHCLGNQLGGGIQNPIPRYQRTPYTKAPPAERRSSWASPSLSAQQQNHLEKLFKQALQTNNDMTRLHKEFKGLSHGCAQSQITNEGSSLACPQISITDEYNRQHNIAPSASSFDPVSIFQKNAQEVVFGQRPATAIGFSSTSFSGMSTPEQTTRSIDDRVRSIVCTLPFTEVIDELKASLNILKIPFSESHEMVYEPQVTEMRRLSLPSGVEIGVAVLPPEHKAHVEFAIINNDSPTSEYLCDQLICRLRMIDPSWSSE |
Post-translational modification
Autophosphorylated. Elevated cAMP levels appears to act via PKA to directly or indirectly phosphorylate multiple sites on kin-29 and inhibit function.
Proteomic databases
PTM databases
Expression
Tissue specificity
Primarily neuronal, with additional expression in body wall muscle and hypodermal cells. Among neuronal cells, expressed in multiple sensory neurons and interneurons in the lateral, anterior, and lumbar ganglia, as well as in motor neurons in the ventral motor cord. Present in the AWB and AWC olfactory neurons.
Developmental stage
Expressed throughout all stages of postembryonic development. Observed in the intestine and in cells in the tail during L1, L3 and L4.
Gene expression databases
Interaction
Subunit
Interacts with tax-6.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q21017 | tax-6 Q0G819 | 3 | EBI-2893174, EBI-323063 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 16-267 | Protein kinase | ||||
Sequence: YDVGRAIGKGNFATVRIARHKIAKTKVAIKSIDVSALDRENLIKLEREVKIVKVIDHPHIVKSYEIMRVDNMLYIVSEYCSSGELYETLIEKGRVAENVARKWFSETASAVAYLHSQGIVHRDLKAENILLGKNSNIKIIDFGFSNFQTGDQLLNTWCGSPPYAAPELLLGNSYDGMKADIWSMGVLLYILVAGGFPFPSDSVNKLKRSVLSGLVKIPYWVSVECADFIRKMLVLNPGKRYTIQNVLQHRWM | ||||||
Region | 348-367 | Disordered | ||||
Sequence: EGTGEEFPRRGSRGSILSGK | ||||||
Compositional bias | 389-418 | Polar residues | ||||
Sequence: LSSPDCDSDDSSNSDLCDDSPMSSMGPMNH | ||||||
Region | 389-423 | Disordered | ||||
Sequence: LSSPDCDSDDSSNSDLCDDSPMSSMGPMNHERQFG | ||||||
Region | 577-602 | Disordered | ||||
Sequence: NPIPRYQRTPYTKAPPAERRSSWASP |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length822
- Mass (Da)91,365
- Last updated2001-10-01 v2
- Checksum0BA31A3FB654B2D6
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 389-418 | Polar residues | ||||
Sequence: LSSPDCDSDDSSNSDLCDDSPMSSMGPMNH |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF403714 EMBL· GenBank· DDBJ | AAK97497.1 EMBL· GenBank· DDBJ | mRNA | ||
FO081451 EMBL· GenBank· DDBJ | CCD71675.1 EMBL· GenBank· DDBJ | Genomic DNA |