Q21017 · KIN29_CAEEL

  • Protein
    Serine/threonine-protein kinase kin-29
  • Gene
    kin-29
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Regulates chemoreceptor expression by phosphorylating the hda-4 class II histone deacetylase (HDAC) and inhibiting the gene repression functions of hda-4 and the mef-2 transcription factor, enabling the correct sensing and transduction of food signals. Role in determining body size, the dauer decision and serotonin-mediated egg laying. May modulate the Sma/Mab pathway and regulates development in the later larval stages.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site22-30ATP (UniProtKB | ChEBI)
Binding site45ATP (UniProtKB | ChEBI)
Active site138Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular Functionhistone deacetylase inhibitor activity
Molecular Functionmetal ion binding
Molecular Functionprotein kinase activity
Molecular Functionprotein serine kinase activity
Molecular Functionprotein serine/threonine kinase activity
Biological Processdauer entry
Biological Processdauer larval development
Biological Processintracellular signal transduction
Biological Processnegative regulation of fatty acid biosynthetic process
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of growth rate
Biological Processpositive regulation of multicellular organism growth
Biological Processregulation of multicellular organism growth
Biological Processreproductive process
Biological Processresponse to heat
Biological Processtransforming growth factor beta receptor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine/threonine-protein kinase kin-29
  • EC number

Gene names

    • Name
      kin-29
    • Synonyms
      sma-11
    • ORF names
      F58H12.1

Organism names

  • Taxonomic identifier
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    Q21017

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Nucleus
Note: Nuclear in larval stage. Predominantly cytoplasmic in the adult but translocates into the nucleus following heat shock.

Keywords

Phenotypes & Variants

Disruption phenotype

Defective in the expression of a set of chemoreceptor genes, and exhibit characteristics associated with altered sensory signaling, including increased lifespan, decreased body size, and deregulated entry into the dauer developmental stage. Exhibit defects in food-induced quiescence behavior.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003986191-822Serine/threonine-protein kinase kin-29

Post-translational modification

Autophosphorylated. Elevated cAMP levels appears to act via PKA to directly or indirectly phosphorylate multiple sites on kin-29 and inhibit function.

Proteomic databases

PTM databases

Expression

Tissue specificity

Primarily neuronal, with additional expression in body wall muscle and hypodermal cells. Among neuronal cells, expressed in multiple sensory neurons and interneurons in the lateral, anterior, and lumbar ganglia, as well as in motor neurons in the ventral motor cord. Present in the AWB and AWC olfactory neurons.

Developmental stage

Expressed throughout all stages of postembryonic development. Observed in the intestine and in cells in the tail during L1, L3 and L4.

Gene expression databases

    • WBGene00002210Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues

Interaction

Subunit

Interacts with tax-6.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q21017tax-6 Q0G8193EBI-2893174, EBI-323063

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain16-267Protein kinase
Region348-367Disordered
Compositional bias389-418Polar residues
Region389-423Disordered
Region577-602Disordered

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    822
  • Mass (Da)
    91,365
  • Last updated
    2001-10-01 v2
  • Checksum
    0BA31A3FB654B2D6
MAAPRRRMGLEKIGLYDVGRAIGKGNFATVRIARHKIAKTKVAIKSIDVSALDRENLIKLEREVKIVKVIDHPHIVKSYEIMRVDNMLYIVSEYCSSGELYETLIEKGRVAENVARKWFSETASAVAYLHSQGIVHRDLKAENILLGKNSNIKIIDFGFSNFQTGDQLLNTWCGSPPYAAPELLLGNSYDGMKADIWSMGVLLYILVAGGFPFPSDSVNKLKRSVLSGLVKIPYWVSVECADFIRKMLVLNPGKRYTIQNVLQHRWMHIRDDVQKNQAAQLLEAIPSSSIEIRQQSTKLNPTIMMFMQQHGKWSEEQIIDAVLGRDFESPIFATYELLADKVKKGTLEGTGEEFPRRGSRGSILSGKANVDEQPLTPTISAHQLAQLNLSSPDCDSDDSSNSDLCDDSPMSSMGPMNHERQFGTPHGLDIIGNRFENRRHTLCASEQLLSPNMMGQFPPPNLLLNNFSMNPPLGFPPMPEGQAAEFPLPSLHPAFATIPIADLSKMLPVPKSERRASAGETLLPTNFDLTQHLANLPAPPISFPTVEEEGKSYLSKYGGKRNTVHCLGNQLGGGIQNPIPRYQRTPYTKAPPAERRSSWASPSLSAQQQNHLEKLFKQALQTNNDMTRLHKEFKGLSHGCAQSQITNEGSSLACPQISITDEYNRQHNIAPSASSFDPVSIFQKNAQEVVFGQRPATAIGFSSTSFSGMSTPEQTTRSIDDRVRSIVCTLPFTEVIDELKASLNILKIPFSESHEMVYEPQVTEMRRLSLPSGVEIGVAVLPPEHKAHVEFAIINNDSPTSEYLCDQLICRLRMIDPSWSSE

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias389-418Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF403714
EMBL· GenBank· DDBJ
AAK97497.1
EMBL· GenBank· DDBJ
mRNA
FO081451
EMBL· GenBank· DDBJ
CCD71675.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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