Q20JQ9 · Q20JQ9_DANRE
- ProteinSodium channel protein
- Genescn1laa
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1955 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | voltage-gated sodium channel complex | |
Molecular Function | voltage-gated sodium channel activity | |
Biological Process | membrane depolarization during action potential | |
Biological Process | neuronal action potential | |
Biological Process | sodium ion transmembrane transport |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSodium channel protein
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ20JQ9
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 125-148 | Helical | ||||
Sequence: ILVHFLFNFIIICTILANCAFMVY | ||||||
Transmembrane | 193-216 | Helical | ||||
Sequence: WLDFIVIVMAYVTEFVDLGSVSAL | ||||||
Transmembrane | 228-245 | Helical | ||||
Sequence: ISVVPGLKTIVGALIQSV | ||||||
Transmembrane | 251-274 | Helical | ||||
Sequence: VMILTLFCLSVFALVGLQLFMGIL | ||||||
Transmembrane | 382-409 | Helical | ||||
Sequence: YMIFFVLVIFLGSFYLVNLILAVVAMAY | ||||||
Transmembrane | 736-754 | Helical | ||||
Sequence: LFITICIVINTVFMAMECY | ||||||
Transmembrane | 766-786 | Helical | ||||
Sequence: TANVVFIGIFTAEMIFKVIAL | ||||||
Transmembrane | 798-823 | Helical | ||||
Sequence: IFDSIIVTLSLMELCLANVLSGIGFL | ||||||
Transmembrane | 844-872 | Helical | ||||
Sequence: LIKIIGNSLGALSNLTLVLAIIVFIFAVV | ||||||
Transmembrane | 932-957 | Helical | ||||
Sequence: LCLTVFMMVMVIGNLVVLNLFLALLL | ||||||
Transmembrane | 1167-1186 | Helical | ||||
Sequence: SWFETFIVFMILLSSGALAF | ||||||
Transmembrane | 1207-1226 | Helical | ||||
Sequence: VFTYIFILEMLLKWVAYGFA | ||||||
Transmembrane | 1232-1254 | Helical | ||||
Sequence: LWCWLDFVIVDVSLISLVANALN | ||||||
Transmembrane | 1299-1319 | Helical | ||||
Sequence: VLLVCLIFWLIFSIVGVNFFA | ||||||
Transmembrane | 1368-1386 | Helical | ||||
Sequence: YLALLQVATFKGWMPIMYA | ||||||
Transmembrane | 1406-1429 | Helical | ||||
Sequence: YLYFVIFIILGAFFTLNLFIGVII | ||||||
Transmembrane | 1488-1506 | Helical | ||||
Sequence: AFDIFIMVLIWLNMVTMML | ||||||
Transmembrane | 1518-1536 | Helical | ||||
Sequence: ALYWINVIFIVLFTTECVL | ||||||
Transmembrane | 1548-1568 | Helical | ||||
Sequence: VGWNVFDFIVVILSIVGMSLT | ||||||
Transmembrane | 1605-1633 | Helical | ||||
Sequence: LLFALMMSLPALFNIGLLLFLVMFIYAIF | ||||||
Transmembrane | 1707-1732 | Helical | ||||
Sequence: IGIFFFVSYIIICFLIVVNMYIAVIL |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 27-51 | Basic and acidic residues | ||||
Sequence: RIAEENAKKSKNTEERNKDNECSRK | ||||||
Region | 27-55 | Disordered | ||||
Sequence: RIAEENAKKSKNTEERNKDNECSRKPNSG | ||||||
Domain | 128-415 | Ion transport | ||||
Sequence: HFLFNFIIICTILANCAFMVYTQTPDWAKNVEYVFTGIYTLEALVKITARGFCVGRFTFLRDPWNWLDFIVIVMAYVTEFVDLGSVSALRAFRVLRALKTISVVPGLKTIVGALIQSVKKLSDVMILTLFCLSVFALVGLQLFMGILKQKCVYSTSFTENKEACYKNKTCRDYINNPSNQYFLPGKKDALICGNSSDAGQCPEGYTCLKAGKNPDYGYTSFDSFGWAFLSLFRLMTQDFWENLYQQTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYDEQNQA | ||||||
Region | 438-536 | Disordered | ||||
Sequence: EQEAEAAAEQSKCEGLSGEKTDSSSDASKLSSKSAKERRNRKKKRQHQGESEKEEDSIKEGNDRKPNFTFAVDGKIRRSRDRSYTSPRQSPLSFQGSLL | ||||||
Compositional bias | 484-500 | Basic and acidic residues | ||||
Sequence: HQGESEKEEDSIKEGND | ||||||
Compositional bias | 507-521 | Basic and acidic residues | ||||
Sequence: FAVDGKIRRSRDRSY | ||||||
Compositional bias | 522-536 | Polar residues | ||||
Sequence: TSPRQSPLSFQGSLL | ||||||
Domain | 527-682 | Voltage-gated Na+ ion channel cytoplasmic | ||||
Sequence: SPLSFQGSLLTPRRDSKASVFSFRGRIHSDNNYADDEQSMFEETGSRRDSLFLPTRPERLFSNVSKSSLTPHLLLPSNGKARYVDDSNGMVMVTSGASAPNSPVIALNTPEVSRKRAMFDDTCADSDDERRSRCNSQNFSKAYRQSMRERALSVAS | ||||||
Domain | 732-962 | Ion transport | ||||
Sequence: PFADLFITICIVINTVFMAMECYPMDGPYSSMLSTANVVFIGIFTAEMIFKVIALDPYSYFLEGWNIFDSIIVTLSLMELCLANVLSGIGFLRPFRLLRVFKLAKSWPTLNMLIKIIGNSLGALSNLTLVLAIIVFIFAVVGMQLFGKSYGECVCKISSDCMLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQPLCLTVFMMVMVIGNLVVLNLFLALLLSSFSA | ||||||
Domain | 971-1161 | Sodium ion transport-associated | ||||
Sequence: EDENNLQIAVRRIRKGFTFIKTCLQSFFRSGCLRKKKQKSADGNMIVNCKERKDSTNHTTIELVKSTGGTDLDSDTENFISNPSLTVSVPIAAEESDFECLNTEDFSSLSSDLEEDKEKLSDVASSFSEGSTVDLRPLGKDGEDALELVLEEEAYPEPCFTAGCVRRFRCCQVDEEKGIWKKWWLLRQTCY | ||||||
Domain | 1166-1438 | Ion transport | ||||
Sequence: HSWFETFIVFMILLSSGALAFEDIYLDTRKSVKTILEFADKVFTYIFILEMLLKWVAYGFAKYFTNLWCWLDFVIVDVSLISLVANALNYSELSAIKSLRTLRAFRPLRALSRFDGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIVGVNFFAGKFSECINITTEQRLPVSEVYNKTDCERMGKGVRWRNVIINFDNVGNGYLALLQVATFKGWMPIMYAAVDSRNPEEQPEYEVNLYMYLYFVIFIILGAFFTLNLFIGVIIDNFNQQKKK | ||||||
Domain | 1487-1742 | Ion transport | ||||
Sequence: QAFDIFIMVLIWLNMVTMMLETEDQSIEMTRALYWINVIFIVLFTTECVLKMIALRHYFFTVGWNVFDFIVVILSIVGMSLTEVIKKYFVSPTLFRVIRLARIGRVLRLIRSAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKTAGIDDMFNFETFPNSMLCLFQITTSGGWDGLLAPMLNSKPPDCDPTKNFTGSSVVGDCGNPSIGIFFFVSYIIICFLIVVNMYIAVILENFSVATEES | ||||||
Region | 1884-1955 | Disordered | ||||
Sequence: VRNFKKKNKHQNGKVPSNQSMDKDMCNEDSDATAATSSPPSYSSITENAKNKYEKDKHEKEVGDKGNQVKKK | ||||||
Compositional bias | 1913-1931 | Polar residues | ||||
Sequence: SDATAATSSPPSYSSITEN | ||||||
Compositional bias | 1932-1955 | Basic and acidic residues | ||||
Sequence: AKNKYEKDKHEKEVGDKGNQVKKK |
Sequence similarities
Belongs to the sodium channel (TC 1.A.1.10) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,955
- Mass (Da)222,675
- Last updated2006-04-18 v1
- ChecksumA3BB26464F939661
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0R4IUM7 | A0A0R4IUM7_DANRE | scn1laa | 1955 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 27-51 | Basic and acidic residues | ||||
Sequence: RIAEENAKKSKNTEERNKDNECSRK | ||||||
Compositional bias | 484-500 | Basic and acidic residues | ||||
Sequence: HQGESEKEEDSIKEGND | ||||||
Compositional bias | 507-521 | Basic and acidic residues | ||||
Sequence: FAVDGKIRRSRDRSY | ||||||
Compositional bias | 522-536 | Polar residues | ||||
Sequence: TSPRQSPLSFQGSLL | ||||||
Compositional bias | 1913-1931 | Polar residues | ||||
Sequence: SDATAATSSPPSYSSITEN | ||||||
Compositional bias | 1932-1955 | Basic and acidic residues | ||||
Sequence: AKNKYEKDKHEKEVGDKGNQVKKK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DQ149503 EMBL· GenBank· DDBJ | ABA54918.1 EMBL· GenBank· DDBJ | mRNA |