Q20JQ3 · Q20JQ3_DANRE
- ProteinSodium channel protein
- Genescn8ab
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1958 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | voltage-gated sodium channel complex | |
Molecular Function | voltage-gated sodium channel activity | |
Biological Process | axon regeneration | |
Biological Process | fin regeneration | |
Biological Process | membrane depolarization during action potential | |
Biological Process | neuronal action potential | |
Biological Process | sodium ion transmembrane transport |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSodium channel protein
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ20JQ3
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 130-153 | Helical | ||||
Sequence: ILIHSFFSMIIMCTILTNCVFMTF | ||||||
Transmembrane | 256-276 | Helical | ||||
Sequence: VMILTVFCLSVFALIGLQLFM | ||||||
Transmembrane | 350-368 | Helical | ||||
Sequence: YGYTSFDSFGWAFLALFRL | ||||||
Transmembrane | 389-416 | Helical | ||||
Sequence: YMIFFVLVIFVGSFYLVNLILAVVAMAY | ||||||
Transmembrane | 727-745 | Helical | ||||
Sequence: FVDLAITICIVLNTVFMAM | ||||||
Transmembrane | 757-775 | Helical | ||||
Sequence: VLSVGNLVFTGIFTAEMFA | ||||||
Transmembrane | 837-865 | Helical | ||||
Sequence: LIKIIGNSVGALGNLTLVLAIIVFIFAVV | ||||||
Transmembrane | 927-950 | Helical | ||||
Sequence: LIVFMMVMVIGNLVVLNLFLALLL | ||||||
Transmembrane | 1174-1192 | Helical | ||||
Sequence: WFETLIIFMILLSSGALAF | ||||||
Transmembrane | 1213-1232 | Helical | ||||
Sequence: VFTYIFILEMLLKWVAYGFV | ||||||
Transmembrane | 1244-1264 | Helical | ||||
Sequence: FFIVDVSIVSLIANALGYSDL | ||||||
Transmembrane | 1290-1316 | Helical | ||||
Sequence: VVVNALVGAIPSIMNVPLVCLIFWLIF | ||||||
Transmembrane | 1413-1439 | Helical | ||||
Sequence: IYMYIYFVIFIIFGSFFTLNLFIGVII | ||||||
Transmembrane | 1498-1516 | Helical | ||||
Sequence: AFDISIMMLICLNMVTMMV | ||||||
Transmembrane | 1528-1550 | Helical | ||||
Sequence: ILYWINFVFIVAFTGEFVLKLFA | ||||||
Transmembrane | 1562-1581 | Helical | ||||
Sequence: VFDCVVVILSIVGMFLADLI | ||||||
Transmembrane | 1625-1650 | Helical | ||||
Sequence: ALFNIGLLLFLVMFIFSIFGMSNFAY | ||||||
Transmembrane | 1718-1741 | Helical | ||||
Sequence: IFFFVMYIIVSFLIVVNMYIAIIL |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 30-59 | Basic and acidic residues | ||||
Sequence: AEEKKKKPVKPRSDSSHRDDDDDNKPKPNS | ||||||
Region | 30-66 | Disordered | ||||
Sequence: AEEKKKKPVKPRSDSSHRDDDDDNKPKPNSDLEAGKG | ||||||
Domain | 133-422 | Ion transport | ||||
Sequence: HSFFSMIIMCTILTNCVFMTFSNPPEWSKQVEYTFTGIYTFESLTKIVARGFCIDDFTFLRDPWNWLDFMVISMAYVTEFVDLGNVSALRTFRVLRALKTISVIPRLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRQKCVIWPVNSTETYLANGSKGFDFNEYIMNDTNFYFLPGMLDALLCGNSSDSGRCPEGYTCMKAGRNPNYGYTSFDSFGWAFLALFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQA | ||||||
Region | 445-528 | Disordered | ||||
Sequence: QEEAQANAMATSAGTVSEDAVEDDGGGHLSRSSSEVSKLSSKSAKERRNRKKKWRKEQEEKGDSEKVVKSESDDGSKRSRFRFR | ||||||
Compositional bias | 497-528 | Basic and acidic residues | ||||
Sequence: KWRKEQEEKGDSEKVVKSESDDGSKRSRFRFR | ||||||
Domain | 542-674 | Voltage-gated Na+ ion channel cytoplasmic | ||||
Sequence: SLLSIPGSPFMSRRSSIFSFKGSENEFADDEHSTVEESEDRRGSLFVPYRRSSYSGYSQGSSRINPLAPHPGCKRNSTVDCNGVVSLIGPGPGRLLPETTEVEGKRKHSGSLMVSVDQLNTSFSRKERANSAM | ||||||
Domain | 726-956 | Ion transport | ||||
Sequence: PFVDLAITICIVLNTVFMAMEHYPMTPRFEEVLSVGNLVFTGIFTAEMFAKLIAMDPYYYFQEGWNIFDGFIVSLSLVELGLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIAESCELPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQSMCLIVFMMVMVIGNLVVLNLFLALLLSSFSAD | ||||||
Domain | 964-1167 | Sodium ion transport-associated | ||||
Sequence: DGEMNNLQISVIRIKKGIAWFKIHVRLLVAHVLKKKPLEDEDKPLDDMYDKKLNLMGNHTGVEIKCGDLNYPKNGNGTTSGIGSSVGKYMIDEEPMSFIHNPNLTVRVPIAVGGSDFENLNTEDFSSESDVENSKDLDDTSSSEGSTIDIKPDEEEMAVVEVVEEYLDPEACWTDACVARYKCCDVPITEGWGKYWWFLRKTCY | ||||||
Region | 1086-1113 | Disordered | ||||
Sequence: EDFSSESDVENSKDLDDTSSSEGSTIDI | ||||||
Domain | 1172-1448 | Ion transport | ||||
Sequence: HNWFETLIIFMILLSSGALAFEDVYIEQRKTIQIILEYADRVFTYIFILEMLLKWVAYGFVKYFTNAWCWLDFFIVDVSIVSLIANALGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVPLVCLIFWLIFSIMGVNLFAGKYYYCFNQTAEEYFQVDVVNNKTECFALINANYTEVRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKVEDQPLYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK | ||||||
Domain | 1497-1751 | Ion transport | ||||
Sequence: QAFDISIMMLICLNMVTMMVETDDQSDETENILYWINFVFIVAFTGEFVLKLFALRHYYFTNGWNVFDCVVVILSIVGMFLADLIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKREIGIDDMYNFETFGNSMICLFMITTSAGWDGLLAPILNYPPDCDPNKENPGTTVKGNCGNPSVGIFFFVMYIIVSFLIVVNMYIAIILENFSVATEES | ||||||
Region | 1896-1958 | Disordered | ||||
Sequence: PANNKLENGGGNQEKKEGTPSTASLPSYDSVTKPEKEKQDDNNEGKGRKEKGRNQKDVRESKC | ||||||
Compositional bias | 1901-1924 | Polar residues | ||||
Sequence: LENGGGNQEKKEGTPSTASLPSYD | ||||||
Compositional bias | 1926-1958 | Basic and acidic residues | ||||
Sequence: VTKPEKEKQDDNNEGKGRKEKGRNQKDVRESKC |
Sequence similarities
Belongs to the sodium channel (TC 1.A.1.10) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,958
- Mass (Da)222,546
- Last updated2006-04-18 v1
- Checksum47754D24E5B0DB11
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M2BDE6 | A0A8M2BDE6_DANRE | scn8ab | 1969 | ||
A0A8M3ATI6 | A0A8M3ATI6_DANRE | scn8ab | 1958 | ||
A0A8M9QAH6 | A0A8M9QAH6_DANRE | scn8ab | 1969 | ||
A0A8M2BDI5 | A0A8M2BDI5_DANRE | scn8ab | 1958 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 30-59 | Basic and acidic residues | ||||
Sequence: AEEKKKKPVKPRSDSSHRDDDDDNKPKPNS | ||||||
Compositional bias | 497-528 | Basic and acidic residues | ||||
Sequence: KWRKEQEEKGDSEKVVKSESDDGSKRSRFRFR | ||||||
Compositional bias | 1901-1924 | Polar residues | ||||
Sequence: LENGGGNQEKKEGTPSTASLPSYD | ||||||
Compositional bias | 1926-1958 | Basic and acidic residues | ||||
Sequence: VTKPEKEKQDDNNEGKGRKEKGRNQKDVRESKC |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DQ149509 EMBL· GenBank· DDBJ | ABA54924.1 EMBL· GenBank· DDBJ | mRNA |