Q20970 · SYMC_CAEEL
- ProteinMethionine--tRNA ligase, cytoplasmic
- Genemars-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids917 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | aminoacyl-tRNA synthetase multienzyme complex | |
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | methionine-tRNA ligase activity | |
Molecular Function | tRNA binding | |
Biological Process | methionyl-tRNA aminoacylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMethionine--tRNA ligase, cytoplasmic
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ20970
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000139265 | 1-917 | Methionine--tRNA ligase, cytoplasmic | |||
Sequence: MGHDLADIKKSFEASLPGYVEKKDPKSILPQPGKRNILITAALPYVNNVPHLGNIIGCVLSADVFARYCNLRGHQTFYVGGTDEYGTATETKALQEGCTPRELCDKYHAIHKGIYEWFGIDFSHFGRTTTDHQTEICQDMFLKLHKNGYTSSQSVDQLYCNQCEKFLADRFVTGTCPMCAYDDARGDQCDGCGKLINAVDLKDAKCHMCKATPEVKQSTHIFLSLDKLQQKTTEHLDRELAKEDNRWSSNAVGITKAWMKLGLDPRCITRDLKWGTAVPLDGFEKKVFYVWFDAPIGYLSITKCVLGDNWTKWWKNPENVELFNFVGKDNVAFHAVMFPCSQLGANDNYTVVNNLCATEYLNYEDTKFSKSRGTGIFGDAAQGTEIPADIWRFYLLYMRPESQDTAFSWDDFVLKVNSELLNNLGNFINRALSFVANSFGGVVPEMNLTNDDAEVLSEIHNECMQWDKQFDGVHLKDAVKTILNVSRLGNQYMQAQTPWVLMKKDEEGKKRAGTIIGVAANIAYHVSVLLYPIMPTISATIREQCGLPALPLFTPFPICYLKAGHKIGQPSPLFQKLDPAQIAEFKAKFGGSQDAQSSAPKTAEKPKQQKKQAPTKDKKGDKKMASTAAFVELEQGAKVISQLIAQNLKKFDQAKALFTRNQLQRLDGENKQLTIDVKTLQHQLIELETAAGIKQVPKPVVSCTPTPTSTPASGIITEAPKKEAPSTPAPSEPKKAKEQKKGKGGAAAAPVDDTIDVGRLDMRVGRIIKCEKHPDADALYVEQIDVGESAPRTVVSGLVRHVPLDQMQNRLVVVLCNLKPAKMRGVESRAMVMCASSPDKVEIMEVPADSKPGTPVVCPPYTHRPDEQLNPKKKIWETVAEDLKVSAEGFAEWKGQPLLIGSESKMTAPTLRGVHVK |
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for motif, region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 44-54 | 'HIGH' region | ||||
Sequence: PYVNNVPHLGN | ||||||
Motif | 367-371 | 'KMSKS' region | ||||
Sequence: KFSKS | ||||||
Region | 591-623 | Disordered | ||||
Sequence: GSQDAQSSAPKTAEKPKQQKKQAPTKDKKGDKK | ||||||
Compositional bias | 604-623 | Basic and acidic residues | ||||
Sequence: EKPKQQKKQAPTKDKKGDKK | ||||||
Region | 702-749 | Disordered | ||||
Sequence: SCTPTPTSTPASGIITEAPKKEAPSTPAPSEPKKAKEQKKGKGGAAAA | ||||||
Domain | 756-857 | tRNA-binding | ||||
Sequence: DVGRLDMRVGRIIKCEKHPDADALYVEQIDVGESAPRTVVSGLVRHVPLDQMQNRLVVVLCNLKPAKMRGVESRAMVMCASSPDKVEIMEVPADSKPGTPVV |
Sequence similarities
Belongs to the class-I aminoacyl-tRNA synthetase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length917
- Mass (Da)101,714
- Last updated1996-11-01 v1
- Checksum3B42AABA314FBDF0
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
D3YT56 | D3YT56_CAEEL | mars-1 | 294 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 604-623 | Basic and acidic residues | ||||
Sequence: EKPKQQKKQAPTKDKKGDKK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z73427 EMBL· GenBank· DDBJ | CAA97803.1 EMBL· GenBank· DDBJ | Genomic DNA |