Q20176 · NAS39_CAEEL
- ProteinZinc metalloproteinase nas-39
- Genenas-39
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids928 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Metalloprotease.
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular space | |
Molecular Function | calcium ion binding | |
Molecular Function | metalloendopeptidase activity | |
Molecular Function | serine-type endopeptidase activity | |
Molecular Function | zinc ion binding | |
Biological Process | dorsal/ventral pattern formation | |
Biological Process | protein processing |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameZinc metalloproteinase nas-39
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ20176
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
No visible phenotype.
PTM/Processing
Features
Showing features for chain, signal, propeptide, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000028943 | ?-928 | Zinc metalloproteinase nas-39 | |||
Sequence: MRFSANIAIIVNIIFLFIVVEFVLPTFIRSGDVRFRRYYRNNGRVSRAATAKKERIWPEGIIPFVIASNFSGEHQHLFLRAMRHWENFTCVSFVPRQPHHKHYITFTVDKCGCCSYVGRRGEGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDMYVDIFYKSIQTGQDYNFEKSKPEEVDSLGEPYDFSSIMHYARDTFSRGAFYDTILPKPNSGFRLEIGQRVQLSEGDIRQTKKLYKCAECGGTLMQESGNLAIQHAGVCTWHIISPQGHTIFLNITGSTLSPPSSLCGKEEDNVITVRDGVSISSPVLDRICGGDSLFRTIASSGNRMLIQVRSSTPAASLPFATYYAICGGPIYANEGVIHSPKYPESYPPNSDCQWTIHVDENSQVAIEFVYFHLEQHKECIYDRLILTEGISKNSKKDGKEMSETFCGLIEKKTIVSKTNQISLRFFSDNSVQKTGFELRFTKELNECATDKNICHHYCVNTVGGFKCACRVGYSLSSNGFSCDSTCGGYLKASNGSISSPNFPEMYPNSKTCIWEIEAPDGYHIFLNFTKFNVEGMKTECAYDYVKIGDSEKLCGEYHEALLFTTPRNRVRIEFSSDSSVERDGFFANFIADFDECQNDNAGCEHTCQNRLGSYVCTCNPGYILAEDKHNCKEGSCFFEVNAPAGDINSPNYPNDYPKGQNCSWHFVTTPGHRLMLTFSSFQVEEHAQCKYDAVSVYDGGDGSAQLAGVFCGLAPPPLLLSSSNELYLTFSSDASVSRRGFQAHYTSLCGGRLTAESTPGHIYSHATFSDSKYGKNQDCSWIVRAKSPGRGVRIQFSTFNIESEEGCQYDYIEIYDGPEATLERLVGRFCGDTSPEVITSTGPELLLIMHTDNAEEEKGFVAEYREAPRSSSTKRTFVSKTRHSPLEEPIHDRNE | ||||||
Signal | 1-30 | |||||
Sequence: MRFSANIAIIVNIIFLFIVVEFVLPTFIRS | ||||||
Propeptide | PRO_0000442685 | 31-? | ||||
Sequence: MRFSANIAIIVNIIFLFIVVEFVLPTFIRS | ||||||
Glycosylation | 69 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 87 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 90↔246 | |||||
Sequence: CVSFVPRQPHHKHYITFTVDKCGCCSYVGRRGEGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDMYVDIFYKSIQTGQDYNFEKSKPEEVDSLGEPYDFSSIMHYARDTFSRGAFYDTILPKPNSGFRLEIGQRVQLSEGDIRQTKKLYKC | ||||||
Disulfide bond | 111↔133 | |||||
Sequence: CGCCSYVGRRGEGPQAISIGKNC | ||||||
Disulfide bond | 113↔114 | |||||
Sequence: CC | ||||||
Disulfide bond | 249↔268 | |||||
Sequence: CGGTLMQESGNLAIQHAGVC | ||||||
Glycosylation | 283 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 359↔385 | |||||
Sequence: CGGPIYANEGVIHSPKYPESYPPNSDC | ||||||
Disulfide bond | 412↔439 | |||||
Sequence: CIYDRLILTEGISKNSKKDGKEMSETFC | ||||||
Disulfide bond | 480↔491 | |||||
Sequence: CATDKNICHHYC | ||||||
Disulfide bond | 487↔500 | |||||
Sequence: CHHYCVNTVGGFKC | ||||||
Disulfide bond | 502↔515 | |||||
Sequence: CRVGYSLSSNGFSC | ||||||
Disulfide bond | 519↔545 | |||||
Sequence: CGGYLKASNGSISSPNFPEMYPNSKTC | ||||||
Glycosylation | 527 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 560 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 573↔587 | |||||
Sequence: CAYDYVKIGDSEKLC | ||||||
Disulfide bond | 629↔640 | |||||
Sequence: CQNDNAGCEHTC | ||||||
Disulfide bond | 636↔649 | |||||
Sequence: CEHTCQNRLGSYVC | ||||||
Disulfide bond | 651↔664 | |||||
Sequence: CNPGYILAEDKHNC | ||||||
Disulfide bond | 669↔695 | |||||
Sequence: CFFEVNAPAGDINSPNYPNDYPKGQNC | ||||||
Glycosylation | 694 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 722↔744 | |||||
Sequence: CKYDAVSVYDGGDGSAQLAGVFC | ||||||
Disulfide bond | 782↔812 | |||||
Sequence: CGGRLTAESTPGHIYSHATFSDSKYGKNQDC | ||||||
Disulfide bond | 840↔863 | |||||
Sequence: CQYDYIEIYDGPEATLERLVGRFC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in pharyngeal, vulva and body wall muscles, intestine and several neurons.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 48-247 | Peptidase M12A | ||||
Sequence: AATAKKERIWPEGIIPFVIASNFSGEHQHLFLRAMRHWENFTCVSFVPRQPHHKHYITFTVDKCGCCSYVGRRGEGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDMYVDIFYKSIQTGQDYNFEKSKPEEVDSLGEPYDFSSIMHYARDTFSRGAFYDTILPKPNSGFRLEIGQRVQLSEGDIRQTKKLYKCA | ||||||
Domain | 249-359 | CUB 1 | ||||
Sequence: CGGTLMQESGNLAIQHAGVCTWHIISPQGHTIFLNITGSTLSPPSSLCGKEEDNVITVRDGVSISSPVLDRICGGDSLFRTIASSGNRMLIQVRSSTPAASLPFATYYAIC | ||||||
Domain | 360-476 | CUB 2 | ||||
Sequence: GGPIYANEGVIHSPKYPESYPPNSDCQWTIHVDENSQVAIEFVYFHLEQHKECIYDRLILTEGISKNSKKDGKEMSETFCGLIEKKTIVSKTNQISLRFFSDNSVQKTGFELRFTKE | ||||||
Domain | 477-516 | EGF-like 1; calcium-binding | ||||
Sequence: LNECATDKNICHHYCVNTVGGFKCACRVGYSLSSNGFSCD | ||||||
Domain | 519-625 | CUB 3 | ||||
Sequence: CGGYLKASNGSISSPNFPEMYPNSKTCIWEIEAPDGYHIFLNFTKFNVEGMKTECAYDYVKIGDSEKLCGEYHEALLFTTPRNRVRIEFSSDSSVERDGFFANFIAD | ||||||
Domain | 626-665 | EGF-like 2; calcium-binding | ||||
Sequence: FDECQNDNAGCEHTCQNRLGSYVCTCNPGYILAEDKHNCK | ||||||
Domain | 669-781 | CUB 4 | ||||
Sequence: CFFEVNAPAGDINSPNYPNDYPKGQNCSWHFVTTPGHRLMLTFSSFQVEEHAQCKYDAVSVYDGGDGSAQLAGVFCGLAPPPLLLSSSNELYLTFSSDASVSRRGFQAHYTSL | ||||||
Domain | 782-900 | CUB 5 | ||||
Sequence: CGGRLTAESTPGHIYSHATFSDSKYGKNQDCSWIVRAKSPGRGVRIQFSTFNIESEEGCQYDYIEIYDGPEATLERLVGRFCGDTSPEVITSTGPELLLIMHTDNAEEEKGFVAEYREA | ||||||
Region | 895-928 | Disordered | ||||
Sequence: AEYREAPRSSSTKRTFVSKTRHSPLEEPIHDRNE | ||||||
Compositional bias | 913-928 | Basic and acidic residues | ||||
Sequence: KTRHSPLEEPIHDRNE |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length928
- Mass (Da)104,083
- Last updated2022-12-14 v4
- Checksum31069AEA0C5F6894
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 913-928 | Basic and acidic residues | ||||
Sequence: KTRHSPLEEPIHDRNE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX284606 EMBL· GenBank· DDBJ | CCD70820.2 EMBL· GenBank· DDBJ | Genomic DNA |